ID   MAD1_CANGA              Reviewed;         657 AA.
AC   Q6FS63;
DT   27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Spindle assembly checkpoint component MAD1;
DE   AltName: Full=Mitotic arrest deficient protein 1;
GN   Name=MAD1; OrderedLocusNames=CAGL0H03179g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Central component of the spindle assembly checkpoint.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MAD1 family. {ECO:0000305}.
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DR   EMBL; CR380954; CAG59864.1; -; Genomic_DNA.
DR   RefSeq; XP_446931.1; XM_446931.1.
DR   AlphaFoldDB; Q6FS63; -.
DR   SMR; Q6FS63; -.
DR   STRING; 5478.XP_446931.1; -.
DR   EnsemblFungi; CAG59864; CAG59864; CAGL0H03179g.
DR   GeneID; 2888905; -.
DR   KEGG; cgr:CAGL0H03179g; -.
DR   CGD; CAL0131566; CAGL0H03179g.
DR   VEuPathDB; FungiDB:CAGL0H03179g; -.
DR   eggNOG; KOG4593; Eukaryota.
DR   HOGENOM; CLU_026595_0_0_1; -.
DR   InParanoid; Q6FS63; -.
DR   OMA; HHNYSTE; -.
DR   Proteomes; UP000002428; Chromosome H.
DR   GO; GO:0000776; C:kinetochore; IEA:EnsemblFungi.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0044877; F:protein-containing complex binding; IEA:EnsemblFungi.
DR   GO; GO:0090268; P:activation of mitotic cell cycle spindle assembly checkpoint; IEA:EnsemblFungi.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0044774; P:mitotic DNA integrity checkpoint signaling; IEA:EnsemblFungi.
DR   GO; GO:0007094; P:mitotic spindle assembly checkpoint signaling; IEA:EnsemblFungi.
DR   GO; GO:1901925; P:negative regulation of protein import into nucleus during spindle assembly checkpoint; IEA:EnsemblFungi.
DR   GO; GO:0006913; P:nucleocytoplasmic transport; IEA:EnsemblFungi.
DR   InterPro; IPR008672; Mad1.
DR   PANTHER; PTHR23168; PTHR23168; 1.
DR   Pfam; PF05557; MAD; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Coiled coil; Mitosis; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..657
FT                   /note="Spindle assembly checkpoint component MAD1"
FT                   /id="PRO_0000213792"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          96..116
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          46..99
FT                   /evidence="ECO:0000255"
FT   COILED          136..533
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   657 AA;  78157 MW;  297CEC77AD2D1168 CRC64;
     MNNSGSGGSS PFVESPDLVS DGHLHTERKD TPIDVDNWKY KYDNLLNQYE IEKVRWQKEQ
     YDSEKSHEAL HLQLEKARNE IDQLVESKRF LEAQLQSQHP QNTQKEWSHE DNKVNNNSMN
     NDYMLLEEKY KSDVFHLDNS VNELKLELTS CRSLLKKYEE VIEQQSEQIK EIKKTLKKKE
     QELDEIEVNR LKQAHNATNT EEIRQQTNEN ASFSNGYNTL MSMKNSVNYW KNENQQLNQK
     LSEYSDIYQQ LQEAQLEIME LKANLEEWNK FLSNKKQQDN SNDYSIDHFI IEFESQRREL
     NMVTEELAEV KKSYYNSKIL NDELALERNQ LLKLKDDYEN NIINLEKLNH ELEQQKVLLE
     EECSLLKNQI PTKENLNQQI RSTNRNDAEY DSLLDNYKQE TENLTNELKR LNDSLIEQNR
     NQGTEMKKRK LRNGDHININ YSQRLNELQQ NNLSLEKDNE KLRLVVEKLE GKLDDLRKTK
     PKNIRILQQR DSPLLKLQFV RRKENELLRE ENQNLLTMIE NITENRNESF DKIPLTSYNS
     LKYQYEISMD TNKKQEKKFS RLKQIFNKKS LEFIDVVNSL LGFKLEFQQD GRVKIYSCYM
     PNKYLIANLV DNTLKSNLDT VISDWDSLLN DWVVEKGQLP CFLASLTLQL WKMENDS