ID   MAD1_DEBHA              Reviewed;         669 AA.
AC   Q6BSY1;
DT   27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Spindle assembly checkpoint component MAD1;
DE   AltName: Full=Mitotic arrest deficient protein 1;
GN   Name=MAD1; OrderedLocusNames=DEHA2D05126g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS   / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Central component of the spindle assembly checkpoint.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MAD1 family. {ECO:0000305}.
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DR   EMBL; CR382136; CAG86828.2; -; Genomic_DNA.
DR   RefSeq; XP_458689.2; XM_458689.1.
DR   AlphaFoldDB; Q6BSY1; -.
DR   SMR; Q6BSY1; -.
DR   STRING; 4959.XP_458689.2; -.
DR   PRIDE; Q6BSY1; -.
DR   EnsemblFungi; CAG86828; CAG86828; DEHA2D05126g.
DR   GeneID; 2901092; -.
DR   KEGG; dha:DEHA2D05126g; -.
DR   VEuPathDB; FungiDB:DEHA2D05126g; -.
DR   eggNOG; KOG4593; Eukaryota.
DR   HOGENOM; CLU_418026_0_0_1; -.
DR   InParanoid; Q6BSY1; -.
DR   OMA; HHNYSTE; -.
DR   OrthoDB; 602490at2759; -.
DR   Proteomes; UP000000599; Chromosome D.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007094; P:mitotic spindle assembly checkpoint signaling; IEA:InterPro.
DR   InterPro; IPR008672; Mad1.
DR   PANTHER; PTHR23168; PTHR23168; 1.
DR   Pfam; PF05557; MAD; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Coiled coil; Mitosis; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..669
FT                   /note="Spindle assembly checkpoint component MAD1"
FT                   /id="PRO_0000213793"
FT   COILED          24..225
FT                   /evidence="ECO:0000255"
FT   COILED          302..487
FT                   /evidence="ECO:0000255"
FT   COILED          533..573
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   669 AA;  78158 MW;  B47136C63DCE01EC CRC64;
     MSDTASSPFI DRPRSMLDED SEFNSRQLIS NLQFQISSLK TEKSLLQQNK ESMAEKYEAL
     LITKNEEVVS LQNDFDYVFK QRDELQSKYD NSQQINGKTV ESLQVQLKDI TERYDELKEE
     HEYLNSDFKK FCRDNNQVKS DLEFHINSKD QMNEKITSLQ DENKSLCKTN DELIEKLNSI
     SEQLVSNTQD KFSRNLQEQN SKLQRTNNQL QLKVDSLLQH RTSVELLRQK NITLTNKLSS
     LANLEEKCCK LEIENLELSN KFDTFFKTIE DSVNDDTSRT NESVVIEFMN KYKRLQNLNL
     VLQDKYNQSV TGVKNMQTEL SNMQQKYSEA ISKVESLNET VSTKTEFIDK LERQKLLNVK
     EIEYLRDSLK KLEELNLKRS KEETNDKSTE QYMTNLEKLV DEYRTEINTL QKQMSSQEIQ
     SNVQSGSKRP RIIDNGIQND FKSQVSVLEK ENLKLLSTIK NLEYNNKTLG EKLQNLESLD
     NKKKELHILQ LKSNPASQDQ LIKQQTLDLL SKENQEMIET FVKNKSAHDM IPKSLFERQE
     NDKLQLQTKI DQLNKRISRL RDIYSQKSRD ILSVISKFFG YTIEFLPSPI NSNDLSSRIK
     LVSKYMNNKD ESNSAYLILD VNSKSLKANG SLEFKTLCED LVTNWIREKD QIPCFLSALN
     LSIYDKYVS