ID   MAD1_KLUDE              Reviewed;         674 AA.
AC   Q874L7;
DT   13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 48.
DE   RecName: Full=Spindle assembly checkpoint component MAD1;
DE   AltName: Full=Mitotic arrest deficient protein 1;
GN   Name=MAD1;
OS   Kluyveromyces delphensis (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces.
OX   NCBI_TaxID=51657;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=CBS 2170;
RX   PubMed=12620120; DOI=10.1186/gb-2003-4-2-r10;
RA   Wong S., Fares M.A., Zimmermann W., Butler G., Wolfe K.H.;
RT   "Evidence from comparative genomics for a complete sexual cycle in the
RT   'asexual' pathogenic yeast Candida glabrata.";
RL   Genome Biol. 4:R10.1-R10.9(2003).
CC   -!- FUNCTION: Central component of the spindle assembly checkpoint.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MAD1 family. {ECO:0000305}.
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DR   EMBL; AY181250; AAO25612.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q874L7; -.
DR   SMR; Q874L7; -.
DR   PRIDE; Q874L7; -.
DR   PhylomeDB; Q874L7; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007094; P:mitotic spindle assembly checkpoint signaling; IEA:InterPro.
DR   InterPro; IPR008672; Mad1.
DR   PANTHER; PTHR23168; PTHR23168; 1.
DR   Pfam; PF05557; MAD; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Coiled coil; Mitosis; Nucleus.
FT   CHAIN           1..674
FT                   /note="Spindle assembly checkpoint component MAD1"
FT                   /id="PRO_0000213794"
FT   REGION          1..31
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          102..121
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          431..450
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          51..586
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   674 AA;  79989 MW;  CB9E5BEFAF55E747 CRC64;
     MDSDSGGSSP FVESPHGEEV QVRGDETNNT YGQDQWKFKY EGLLNEWEIQ KIQWQKEKYE
     FEKRQLAAED RLRNANDEMD ILIQRNQDLV YRIEEEERNR INNDEGNDLK GGAGSMDKGK
     KQEIEELSRR YEADRFEWKT QNEELDLELK SCKSLISKYE QLLMEQSEKI NSLRSEVKNK
     EDQIAELEVV RQKKDHNITN TEEFRNLTTL KDIIKTHDQY ALDLEQSNMR QAEELKRLKS
     LKESATFWRS ENEQLQERIR QLEEVEQQYN EVQLEILELK VNISEWDRFL KEKCQPGDTE
     TAEYTPSDFV RDYEILQNDY KVLNDEFEDL KKETQMVKIL NDELAMERNQ ILNLKNEYEK
     SIINLEKLNY ELEQQKTLSF EECKLLRKQL ESIKHKSNHE ENDSTKDYEV LIDNYKNQTK
     DLTSELKRMN DELIGSNRDS SAGSKKRKLR TGDSVNVNLA QKLNTMQIEN SNLQKEIHKL
     KAIIDVLEKK IRLLKENKEK RIRILQQRDS PLLKIQFARK QELDLLKDEN KELLSLIENV
     TENNQNRIDT IPLSAYKSLE FQYQQSQENV VKGEKQLSRL KQIYNKKSLE FIDIVNSMLG
     FRLEFMLDGR VKIYSCYKPD KYLIANLIDN TLKSNLDAII SDWDELLSLW VVERGQLPCF
     LATITLRLWE LNPI