ID   MAD1_YARLI              Reviewed;         704 AA.
AC   Q6C452;
DT   27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Spindle assembly checkpoint component MAD1;
DE   AltName: Full=Mitotic arrest deficient protein 1;
GN   Name=MAD1; OrderedLocusNames=YALI0E29623g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Central component of the spindle assembly checkpoint.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MAD1 family. {ECO:0000305}.
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DR   EMBL; CR382131; CAG80164.1; -; Genomic_DNA.
DR   RefSeq; XP_504560.1; XM_504560.1.
DR   AlphaFoldDB; Q6C452; -.
DR   SMR; Q6C452; -.
DR   STRING; 4952.CAG80164; -.
DR   EnsemblFungi; CAG80164; CAG80164; YALI0_E29623g.
DR   GeneID; 2911916; -.
DR   KEGG; yli:YALI0E29623g; -.
DR   VEuPathDB; FungiDB:YALI0_E29623g; -.
DR   HOGENOM; CLU_010064_1_0_1; -.
DR   InParanoid; Q6C452; -.
DR   OMA; YMLLGYR; -.
DR   Proteomes; UP000001300; Chromosome E.
DR   GO; GO:0000776; C:kinetochore; IBA:GO_Central.
DR   GO; GO:0072686; C:mitotic spindle; IBA:GO_Central.
DR   GO; GO:0005635; C:nuclear envelope; IBA:GO_Central.
DR   GO; GO:0051315; P:attachment of mitotic spindle microtubules to kinetochore; IBA:GO_Central.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007094; P:mitotic spindle assembly checkpoint signaling; IBA:GO_Central.
DR   InterPro; IPR008672; Mad1.
DR   PANTHER; PTHR23168; PTHR23168; 1.
DR   Pfam; PF05557; MAD; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Coiled coil; Mitosis; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..704
FT                   /note="Spindle assembly checkpoint component MAD1"
FT                   /id="PRO_0000213797"
FT   REGION          1..53
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          53..603
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        20..50
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   704 AA;  79963 MW;  6694401F85AF66C1 CRC64;
     MSDTPSSPFI EHPETPRKAL FSSNRPSPVR STHATPSLHG TPSTASRFSR TPREDVIGLK
     KTISQLRYDL EALKQEQQVA QILQEEKERE LEAKHKKELD RAEQAESDQV FLFNKQKELS
     DENRTLKEEL RSLQSQHEAD GRELNHELEG LKDLLNDLQS ENRALVSEMN YKIEDYEHRI
     KAASTTTDDL LKEVENRGTA LTEAKMNVVK FEQLVESLKG ESLDLKQSAK DLEAVEQTKS
     QLSDQIKYSR ELEAKVSALT VRVEAAESAQ QLSQVYEEDL SSMKGKLKNM EGLRQQLAEQ
     QLQILVHEEN SAKWKAYLEK SDEFKTVEEV VTALNKARME KASLLERAGS GVNDETRSTA
     EAYARLQERV TTLESELQLA QNQLKTEKKK VATSIRQHTL AANEAKFLRE QLKAYDDEEV
     TAAGADVKQG RIDELEKLLE AVKNEKSVLE GELKEARSEQ GCTVAAGTKR PRADDSVSSE
     VISEYTRKLQ TLQQEFDEVS VEARLLAKTK EALEARLESL EKSQESRVRI LELRENPTSR
     HEAVKQSMLD TLKAENEALM GKNENSKSVP QASLERKQLE LQGVRDKLAS TEKSYQRLKE
     VFSVKSLEFR EAVYALTGYQ IDILRNKKVK VTSMYAQSDE DSFTFLPDPN HKGQFAGVID
     SPLTDEFSNI VDYWVKDKKD FPCFLAALNL ELYERKENNG NQAS