ID   MAD3_DANRE              Reviewed;         200 AA.
AC   Q7SX95;
DT   17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Max dimerization protein 3;
DE            Short=Max dimerizer 3;
DE   AltName: Full=Max-associated protein 3;
DE   AltName: Full=Max-interacting transcriptional repressor MAD3;
GN   Name=mxd3; Synonyms=mad3; ORFNames=zgc:66281;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=SJD;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional repressor. Binds with MAX to form a sequence-
CC       specific DNA-binding protein complex which recognizes the core sequence
CC       5'-CAC[GA]TG-3' (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Efficient DNA binding requires dimerization with another bHLH
CC       protein. Binds DNA as a heterodimer with MAX (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
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DR   EMBL; BC055579; AAH55579.1; -; mRNA.
DR   RefSeq; NP_957350.1; NM_201056.1.
DR   AlphaFoldDB; Q7SX95; -.
DR   SMR; Q7SX95; -.
DR   STRING; 7955.ENSDARP00000074553; -.
DR   PaxDb; Q7SX95; -.
DR   GeneID; 394031; -.
DR   KEGG; dre:394031; -.
DR   CTD; 83463; -.
DR   ZFIN; ZDB-GENE-040426-1588; mxd3.
DR   eggNOG; KOG2483; Eukaryota.
DR   InParanoid; Q7SX95; -.
DR   OrthoDB; 1545091at2759; -.
DR   PhylomeDB; Q7SX95; -.
DR   PRO; PR:Q7SX95; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0032502; P:developmental process; IEA:UniProt.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 4.10.280.10; -; 1.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   Pfam; PF00010; HLH; 1.
DR   SMART; SM00353; HLH; 1.
DR   SUPFAM; SSF47459; SSF47459; 1.
DR   PROSITE; PS50888; BHLH; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..200
FT                   /note="Max dimerization protein 3"
FT                   /id="PRO_0000253710"
FT   DOMAIN          57..109
FT                   /note="bHLH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT   REGION          40..69
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          136..165
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   200 AA;  23019 MW;  65F35D7052661267 CRC64;
     MEVNTCNIQV LLQAAEYLER REREAEHGYA SVLPFYSNGV SDKRKKQKSK SHSSPGNSRS
     VHNELEKHRR AQLRHCLEQL KQQVPLSSDS SRNTTLNLLR QAQLHIKKLQ EQDERAKLLK
     DRLRWEQREL RTRLEKLQGG SERMRSDSLG SAVSSERSDS EREDVEIDVE SMVWTLEADA
     LGSSHAGVDH SYSTSDHAWL