ID   MAD3_XENTR              Reviewed;         200 AA.
AC   Q28DB3;
DT   17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Max dimerization protein 3;
DE            Short=Max dimerizer 3;
DE   AltName: Full=Max-associated protein 3;
DE   AltName: Full=Max-interacting transcriptional repressor MAD3;
GN   Name=mxd3; Synonyms=mad3; ORFNames=TEgg037c06.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional repressor. Binds with MAX to form a sequence-
CC       specific DNA-binding protein complex which recognizes the core sequence
CC       5'-CAC[GA]TG-3' (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Efficient DNA binding requires dimerization with another bHLH
CC       protein. Binds DNA as a heterodimer with MAX (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
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DR   EMBL; CR855600; CAJ81844.1; -; mRNA.
DR   RefSeq; NP_001017299.1; NM_001017299.2.
DR   RefSeq; XP_012814565.1; XM_012959111.2.
DR   AlphaFoldDB; Q28DB3; -.
DR   SMR; Q28DB3; -.
DR   STRING; 8364.ENSXETP00000015728; -.
DR   PaxDb; Q28DB3; -.
DR   Ensembl; ENSXETT00000015728; ENSXETP00000015728; ENSXETG00000007236.
DR   GeneID; 550053; -.
DR   KEGG; xtr:550053; -.
DR   CTD; 83463; -.
DR   Xenbase; XB-GENE-867571; mxd3.
DR   eggNOG; KOG2483; Eukaryota.
DR   HOGENOM; CLU_082604_1_0_1; -.
DR   InParanoid; Q28DB3; -.
DR   OMA; EGQICNI; -.
DR   OrthoDB; 1545091at2759; -.
DR   TreeFam; TF315654; -.
DR   Proteomes; UP000008143; Chromosome 3.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000007236; Expressed in testis and 12 other tissues.
DR   ExpressionAtlas; Q28DB3; baseline.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 4.10.280.10; -; 1.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   Pfam; PF00010; HLH; 1.
DR   SMART; SM00353; HLH; 1.
DR   SUPFAM; SSF47459; SSF47459; 1.
DR   PROSITE; PS50888; BHLH; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..200
FT                   /note="Max dimerization protein 3"
FT                   /id="PRO_0000253712"
FT   DOMAIN          54..106
FT                   /note="bHLH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT   REGION          26..56
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          134..164
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        139..154
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   200 AA;  23130 MW;  B30542F7C4B4AD7A CRC64;
     MEQLPSNLQV LLQAAEYVER REREAEHGYA SILPCDPATP GRRKRQRTNS NPDNVRSVHN
     ELEKHRRAQL RRCLEQLKQQ VPLSMENSRH TTLSLLHRAK QHIKKLEDQE LRAKSLKEKL
     RVEQQKLRQR LKQLLPPNTE RIRTDSLDSS TLSSERSDSD QEDLEVDVEG IILSGNEGEL
     FVSFSAGLEH SYSTPAHAWL