ID   MADCA_RAT               Reviewed;         394 AA.
AC   O70540;
DT   02-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   03-AUG-2022, entry version 132.
DE   RecName: Full=Mucosal addressin cell adhesion molecule 1;
DE            Short=MAdCAM-1;
DE            Short=rMAdCAM-1;
DE   Flags: Precursor;
GN   Name=Madcam1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=WKAH; TISSUE=Lymph node;
RX   PubMed=9512658; DOI=10.1016/s0167-4781(97)00142-5;
RA   Iizuka T., Koike R., Miyasaka N., Miyasaka M., Watanabe T.;
RT   "Cloning and characterization of the rat MAdCAM-1 cDNA and gene.";
RL   Biochim. Biophys. Acta 1395:266-270(1998).
CC   -!- FUNCTION: Cell adhesion leukocyte receptor expressed by mucosal
CC       venules, helps to direct lymphocyte traffic into mucosal tissues
CC       including the Peyer patches and the intestinal lamina propria. It can
CC       bind both the integrin alpha-4/beta-7 and L-selectin, regulating both
CC       the passage and retention of leukocytes (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
CC   -!- TISSUE SPECIFICITY: Detected in Peyer patches and mesenteric lymph
CC       nodes but not in spleen.
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DR   EMBL; D87840; BAA25260.1; -; mRNA.
DR   RefSeq; NP_062190.1; NM_019317.1.
DR   AlphaFoldDB; O70540; -.
DR   SMR; O70540; -.
DR   STRING; 10116.ENSRNOP00000010939; -.
DR   GlyGen; O70540; 1 site.
DR   PaxDb; O70540; -.
DR   Ensembl; ENSRNOT00000010938; ENSRNOP00000010939; ENSRNOG00000008217.
DR   GeneID; 54266; -.
DR   KEGG; rno:54266; -.
DR   UCSC; RGD:3029; rat.
DR   CTD; 8174; -.
DR   RGD; 3029; Madcam1.
DR   eggNOG; ENOG502SR0W; Eukaryota.
DR   GeneTree; ENSGT00510000049549; -.
DR   HOGENOM; CLU_056743_0_0_1; -.
DR   InParanoid; O70540; -.
DR   OMA; RALRIEC; -.
DR   OrthoDB; 1146401at2759; -.
DR   PhylomeDB; O70540; -.
DR   TreeFam; TF337571; -.
DR   Reactome; R-RNO-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
DR   Reactome; R-RNO-216083; Integrin cell surface interactions.
DR   PRO; PR:O70540; -.
DR   Proteomes; UP000002494; Chromosome 7.
DR   Bgee; ENSRNOG00000008217; Expressed in colon and 12 other tissues.
DR   Genevisible; O70540; RN.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:GOC.
DR   GO; GO:0098640; F:integrin binding involved in cell-matrix adhesion; ISO:RGD.
DR   GO; GO:0007568; P:aging; IEP:RGD.
DR   GO; GO:0007155; P:cell adhesion; IDA:RGD.
DR   GO; GO:0007160; P:cell-matrix adhesion; ISO:RGD.
DR   GO; GO:0034113; P:heterotypic cell-cell adhesion; ISO:RGD.
DR   GO; GO:0007229; P:integrin-mediated signaling pathway; ISO:RGD.
DR   GO; GO:0030216; P:keratinocyte differentiation; ISO:RGD.
DR   GO; GO:0050900; P:leukocyte migration; ISO:RGD.
DR   GO; GO:0050901; P:leukocyte tethering or rolling; ISO:RGD.
DR   GO; GO:0002687; P:positive regulation of leukocyte migration; IMP:RGD.
DR   GO; GO:2000403; P:positive regulation of lymphocyte migration; IEA:InterPro.
DR   GO; GO:0043113; P:receptor clustering; ISO:RGD.
DR   Gene3D; 2.60.40.10; -; 2.
DR   InterPro; IPR015169; Adhes-Ig-like.
DR   InterPro; IPR003987; ICAM_VCAM_N.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR037413; MADCAM1.
DR   PANTHER; PTHR14162; PTHR14162; 1.
DR   Pfam; PF09085; Adhes-Ig_like; 1.
DR   PRINTS; PR01472; ICAMVCAM1.
DR   SUPFAM; SSF48726; SSF48726; 2.
PE   2: Evidence at transcript level;
KW   Cell adhesion; Disulfide bond; Glycoprotein; Immunoglobulin domain;
KW   Membrane; Reference proteome; Repeat; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..394
FT                   /note="Mucosal addressin cell adhesion molecule 1"
FT                   /id="PRO_0000014855"
FT   TOPO_DOM        20..353
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        354..374
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        375..394
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          20..107
FT                   /note="Ig-like 1"
FT   DOMAIN          108..225
FT                   /note="Ig-like 2"
FT   DOMAIN          256..345
FT                   /note="Ig-like 3"
FT   REGION          219..255
FT                   /note="Mucin-like"
FT   CARBOHYD        42
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        43..89
FT                   /evidence="ECO:0000250|UniProtKB:Q13477"
FT   DISULFID        47..93
FT                   /evidence="ECO:0000250|UniProtKB:Q13477"
FT   DISULFID        130..198
FT                   /evidence="ECO:0000250|UniProtKB:Q13477"
FT   DISULFID        282..330
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   394 AA;  42507 MW;  3D99490007E7421C CRC64;
     MEPILALLLA LGPFQLSRGQ SFQVNPPEPE VAVAMGTSLQ INCSMSCDKD IARVHWHGLD
     TNLGNVQTLP GSRVLSVRGM LSDTGTRVCV GSCGSRSFQH SVKILVYAFP DQLEVTPEFL
     VPGRDQVVSC TAHNIWPAGP DSLSFALLRG EQSLEGAQAL ETEQEEEMQE TEGTPLFQVT
     QRWLLPSLGT PALPALYCQV TMQLPKLVLT HRRKIPVLQS QTSPEPPSTT SAKPYILTSS
     HTTKAVSTGL SSVALPSTPL SSEGPCYPEI HQNPEADWEL LCEASCGSGV TVHWTLAPGD
     LAAYHKREAG AQAWLSVLPL GPIPEGWFQC RMDPGGQVTS LYVTGQVIPN PSSMVALWIG
     SLVLGLLALA FLAYCLWKRY RPGPLPDSSS CTLL