MADL2_HUMAN
ID MADL2_HUMAN Reviewed; 307 AA.
AC A6NDP7;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-NOV-2009, sequence version 3.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=Myeloid-associated differentiation marker-like protein 2;
GN Name=MYADML2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, and Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC A6NDP7; Q13520: AQP6; NbExp=3; IntAct=EBI-17641390, EBI-13059134;
CC A6NDP7; Q3SXY8: ARL13B; NbExp=3; IntAct=EBI-17641390, EBI-11343438;
CC A6NDP7; P11912: CD79A; NbExp=3; IntAct=EBI-17641390, EBI-7797864;
CC A6NDP7; P21964: COMT; NbExp=3; IntAct=EBI-17641390, EBI-372265;
CC A6NDP7; P34910-2: EVI2B; NbExp=3; IntAct=EBI-17641390, EBI-17640610;
CC A6NDP7; Q5JX71: FAM209A; NbExp=3; IntAct=EBI-17641390, EBI-18304435;
CC A6NDP7; Q8TDT2: GPR152; NbExp=3; IntAct=EBI-17641390, EBI-13345167;
CC A6NDP7; Q8TED1: GPX8; NbExp=3; IntAct=EBI-17641390, EBI-11721746;
CC A6NDP7; Q13113: PDZK1IP1; NbExp=3; IntAct=EBI-17641390, EBI-716063;
CC A6NDP7; Q96GF1: RNF185; NbExp=3; IntAct=EBI-17641390, EBI-2340249;
CC A6NDP7; Q14973: SLC10A1; NbExp=3; IntAct=EBI-17641390, EBI-3923031;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the MAL family. {ECO:0000305}.
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DR EMBL; AC145207; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC029306; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS45815.1; -.
DR RefSeq; NP_001138585.2; NM_001145113.2.
DR AlphaFoldDB; A6NDP7; -.
DR SMR; A6NDP7; -.
DR BioGRID; 129090; 11.
DR IntAct; A6NDP7; 11.
DR STRING; 9606.ENSP00000386702; -.
DR BioMuta; MYADML2; -.
DR MassIVE; A6NDP7; -.
DR PaxDb; A6NDP7; -.
DR PeptideAtlas; A6NDP7; -.
DR PRIDE; A6NDP7; -.
DR Antibodypedia; 71397; 27 antibodies from 11 providers.
DR DNASU; 255275; -.
DR Ensembl; ENST00000409745.2; ENSP00000386702.2; ENSG00000185105.5.
DR GeneID; 255275; -.
DR KEGG; hsa:255275; -.
DR MANE-Select; ENST00000409745.2; ENSP00000386702.2; NM_001145113.3; NP_001138585.2.
DR UCSC; uc010wvf.1; human.
DR CTD; 255275; -.
DR DisGeNET; 255275; -.
DR GeneCards; MYADML2; -.
DR HGNC; HGNC:34548; MYADML2.
DR HPA; ENSG00000185105; Tissue enriched (skeletal).
DR neXtProt; NX_A6NDP7; -.
DR OpenTargets; ENSG00000185105; -.
DR PharmGKB; PA164723246; -.
DR VEuPathDB; HostDB:ENSG00000185105; -.
DR eggNOG; KOG4788; Eukaryota.
DR GeneTree; ENSGT00950000182933; -.
DR HOGENOM; CLU_068368_0_0_1; -.
DR InParanoid; A6NDP7; -.
DR OMA; HLSWGNF; -.
DR OrthoDB; 1056604at2759; -.
DR PhylomeDB; A6NDP7; -.
DR TreeFam; TF331088; -.
DR PathwayCommons; A6NDP7; -.
DR SignaLink; A6NDP7; -.
DR BioGRID-ORCS; 255275; 13 hits in 1071 CRISPR screens.
DR GenomeRNAi; 255275; -.
DR Pharos; A6NDP7; Tdark.
DR PRO; PR:A6NDP7; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; A6NDP7; protein.
DR Bgee; ENSG00000185105; Expressed in hindlimb stylopod muscle and 68 other tissues.
DR Genevisible; A6NDP7; HS.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR008253; Marvel.
DR Pfam; PF01284; MARVEL; 2.
DR PROSITE; PS51225; MARVEL; 2.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix.
FT CHAIN 1..307
FT /note="Myeloid-associated differentiation marker-like
FT protein 2"
FT /id="PRO_0000332206"
FT TRANSMEM 53..73
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 90..110
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 129..149
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 163..183
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..218
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 229..249
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 278..298
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 17..154
FT /note="MARVEL 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00581"
FT DOMAIN 159..303
FT /note="MARVEL 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00581"
FT CONFLICT 116
FT /note="S -> P (in Ref. 2; BC029306)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 307 AA; 32967 MW; 814A830384894673 CRC64;
MGSTMEPPGG AYLHLGAVTS PVGTARVLQL AFGCTTFSLV AHRGGFAGVQ GTFCMAAWGF
CFAVSALVVA CEFTRLHGCL RLSWGNFTAA FAMLATLLCA TAAVLYPLYF ARRECSPEPA
GCAARDFRLA ASVFAGLLFL AYAVEVALTR ARPGQVSSYM ATVSGLLKIV QAFVACIIFG
ALVHDSRYGR YVATQWCVAV YSLCFLATVA VVALSVMGHT GGLGCPFDRL VVVYTFLAVL
LYLSAAVIWP VFCFDPKYGE PKRPPNCARG SCPWDSQLVV AIFTYVNLLL YVVDLAYSQR
IRFVPSL
