MADL2_MOUSE
ID MADL2_MOUSE Reviewed; 307 AA.
AC Q08AU7; Q5BKP1; Q9D1F1;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 16-DEC-2008, sequence version 2.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Myeloid-associated differentiation marker-like protein 2;
GN Name=Myadml2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Heart;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q08AU7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q08AU7-2; Sequence=VSP_033351, VSP_033352;
CC -!- SIMILARITY: Belongs to the MAL family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH91000.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAI09330.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAI25009.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK003645; BAB22911.1; -; mRNA.
DR EMBL; AL663030; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC091000; AAH91000.1; ALT_INIT; mRNA.
DR EMBL; BC109329; AAI09330.1; ALT_INIT; mRNA.
DR EMBL; BC125008; AAI25009.1; ALT_INIT; mRNA.
DR CCDS; CCDS56828.1; -. [Q08AU7-2]
DR CCDS; CCDS88298.1; -. [Q08AU7-1]
DR RefSeq; NP_001191749.1; NM_001204820.1. [Q08AU7-2]
DR RefSeq; NP_081027.1; NM_026751.1. [Q08AU7-1]
DR RefSeq; XP_017170218.1; XM_017314729.1. [Q08AU7-1]
DR AlphaFoldDB; Q08AU7; -.
DR SMR; Q08AU7; -.
DR STRING; 10090.ENSMUSP00000026134; -.
DR PaxDb; Q08AU7; -.
DR PRIDE; Q08AU7; -.
DR ProteomicsDB; 292000; -. [Q08AU7-1]
DR Antibodypedia; 71397; 27 antibodies from 11 providers.
DR Ensembl; ENSMUST00000026134; ENSMUSP00000026134; ENSMUSG00000025141. [Q08AU7-2]
DR Ensembl; ENSMUST00000239158; ENSMUSP00000158986; ENSMUSG00000025141. [Q08AU7-1]
DR GeneID; 68515; -.
DR KEGG; mmu:68515; -.
DR UCSC; uc007mtx.2; mouse. [Q08AU7-1]
DR UCSC; uc029rqg.1; mouse. [Q08AU7-2]
DR CTD; 255275; -.
DR MGI; MGI:1915765; Myadml2.
DR VEuPathDB; HostDB:ENSMUSG00000025141; -.
DR eggNOG; KOG4788; Eukaryota.
DR GeneTree; ENSGT00950000182933; -.
DR HOGENOM; CLU_1712680_0_0_1; -.
DR InParanoid; Q08AU7; -.
DR OMA; HLSWGNF; -.
DR OrthoDB; 1056604at2759; -.
DR BioGRID-ORCS; 68515; 4 hits in 73 CRISPR screens.
DR PRO; PR:Q08AU7; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q08AU7; protein.
DR Bgee; ENSMUSG00000025141; Expressed in hindlimb stylopod muscle and 59 other tissues.
DR Genevisible; Q08AU7; MM.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR008253; Marvel.
DR Pfam; PF01284; MARVEL; 2.
DR PROSITE; PS51225; MARVEL; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Reference proteome; Repeat; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..307
FT /note="Myeloid-associated differentiation marker-like
FT protein 2"
FT /id="PRO_0000332207"
FT TRANSMEM 53..73
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 90..110
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 129..149
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 163..183
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..218
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 232..252
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 278..298
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 17..154
FT /note="MARVEL 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00581"
FT DOMAIN 159..303
FT /note="MARVEL 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00581"
FT VAR_SEQ 125..153
FT /note="RNFRLAASVFAGLLFLAYAAEVALTRARP -> APCQRPAPESPWKDDDVMT
FT AMEYLSRHPT (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_033351"
FT VAR_SEQ 154..307
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_033352"
FT CONFLICT 26
FT /note="R -> Q (in Ref. 3; AAH91000)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 307 AA; 33165 MW; E2944A1B0A97FFEF CRC64;
MGSTMEPPGG AYLHLGAVTS PVGTARMLQL AFGCTTFSLV AHRGGFGGVQ GTFCMAAWGF
CFAFSVLVVA CEFTKLHSCL RLSWGNFTAA FAMLATLLCA TAAVIYPLYF TRLECPPEPA
GCMVRNFRLA ASVFAGLLFL AYAAEVALTR ARPGQVASYM ATVSGLLKIV QAFVACIIFG
ALVHESRYGR YVATQWCVAV YSLCFMATVA VVVLSVMGHT AGLGCPFDRL VIVYTFLAVL
LYLSAAVIWP VFCFDPKYGE PGRPADCLRG SCPWDSQLVV AIFTYVNLLL YIVDLAYSQR
IRFVPTL
