ID   MADS2_VITVI             Reviewed;         244 AA.
AC   Q8LLR2; A5BE01; D7SMN8;
DT   05-JUN-2019, integrated into UniProtKB/Swiss-Prot.
DT   05-JUN-2019, sequence version 2.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Agamous-like MADS-box protein MADS2 {ECO:0000305};
DE   AltName: Full=MADS-box protein 2 {ECO:0000303|Ref.1};
DE            Short=VvMADS2 {ECO:0000303|Ref.1};
DE   AltName: Full=SEPALLATA homolog 1 {ECO:0000305};
DE            Short=VvSEP1 {ECO:0000303|PubMed:18997115};
DE            Short=VviSEP1 {ECO:0000303|PubMed:26818751};
GN   Name=MADS2 {ECO:0000303|Ref.1};
GN   OrderedLocusNames=VIT_14s0083g01050 {ECO:0000312|EMBL:CBI16936.3};
OS   Vitis vinifera (Grape).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; Vitales; Vitaceae; Viteae; Vitis.
OX   NCBI_TaxID=29760;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
RC   STRAIN=cv. Cabernet Sauvignon;
RX   DOI=10.1016/S0168-9452(02)00034-1;
RA   Boss P.K., Sensi E., Hua C., Davies C., Thomas M.R.;
RT   "Cloning and characterization of grapevine (Vitis vinifera L.) MADS-box
RT   genes expressed during inflorescence and berry development.";
RL   Plant Sci. 162:887-895(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Pinot noir / PN40024;
RX   PubMed=17721507; DOI=10.1038/nature06148;
RA   Jaillon O., Aury J.-M., Noel B., Policriti A., Clepet C., Casagrande A.,
RA   Choisne N., Aubourg S., Vitulo N., Jubin C., Vezzi A., Legeai F.,
RA   Hugueney P., Dasilva C., Horner D., Mica E., Jublot D., Poulain J.,
RA   Bruyere C., Billault A., Segurens B., Gouyvenoux M., Ugarte E.,
RA   Cattonaro F., Anthouard V., Vico V., Del Fabbro C., Alaux M.,
RA   Di Gaspero G., Dumas V., Felice N., Paillard S., Juman I., Moroldo M.,
RA   Scalabrin S., Canaguier A., Le Clainche I., Malacrida G., Durand E.,
RA   Pesole G., Laucou V., Chatelet P., Merdinoglu D., Delledonne M.,
RA   Pezzotti M., Lecharny A., Scarpelli C., Artiguenave F., Pe M.E., Valle G.,
RA   Morgante M., Caboche M., Adam-Blondon A.-F., Weissenbach J., Quetier F.,
RA   Wincker P.;
RT   "The grapevine genome sequence suggests ancestral hexaploidization in major
RT   angiosperm phyla.";
RL   Nature 449:463-467(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Pinot noir;
RX   PubMed=18094749; DOI=10.1371/journal.pone.0001326;
RA   Velasco R., Zharkikh A., Troggio M., Cartwright D.A., Cestaro A., Pruss D.,
RA   Pindo M., FitzGerald L.M., Vezzulli S., Reid J., Malacarne G., Iliev D.,
RA   Coppola G., Wardell B., Micheletti D., Macalma T., Facci M., Mitchell J.T.,
RA   Perazzolli M., Eldredge G., Gatto P., Oyzerski R., Moretto M., Gutin N.,
RA   Stefanini M., Chen Y., Segala C., Davenport C., Dematte L., Mraz A.,
RA   Battilana J., Stormo K., Costa F., Tao Q., Si-Ammour A., Harkins T.,
RA   Lackey A., Perbost C., Taillon B., Stella A., Solovyev V., Fawcett J.A.,
RA   Sterck L., Vandepoele K., Grando S.M., Toppo S., Moser C., Lanchbury J.,
RA   Bogden R., Skolnick M., Sgaramella V., Bhatnagar S.K., Fontana P.,
RA   Gutin A., Van de Peer Y., Salamini F., Viola R.;
RT   "A high quality draft consensus sequence of the genome of a heterozygous
RT   grapevine variety.";
RL   PLoS ONE 2:E1326-E1326(2007).
RN   [4]
RP   GENE FAMILY.
RX   PubMed=18997115; DOI=10.1104/pp.108.131052;
RA   Diaz-Riquelme J., Lijavetzky D., Martinez-Zapater J.M., Carmona M.J.;
RT   "Genome-wide analysis of MIKCC-type MADS box genes in grapevine.";
RL   Plant Physiol. 149:354-369(2009).
RN   [5]
RP   GENE FAMILY.
RX   PubMed=26818751; DOI=10.1186/s12864-016-2398-7;
RA   Grimplet J., Martinez-Zapater J.M., Carmona M.J.;
RT   "Structural and functional annotation of the MADS-box transcription factor
RT   family in grapevine.";
RL   BMC Genomics 17:80-80(2016).
CC   -!- FUNCTION: Probable transcription factor involved in flower development.
CC       {ECO:0000250|UniProtKB:Q0HA25}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00251}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q8LLR2-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8LLR2-2; Sequence=VSP_060174;
CC   -!- TISSUE SPECIFICITY: Expressed in flowers and seeds.
CC       {ECO:0000269|Ref.1}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAN59955.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AF373601; AAM21342.1; -; mRNA.
DR   EMBL; FN594955; CBI16936.3; -; Genomic_DNA.
DR   EMBL; FN597038; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AM456103; CAN59955.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; NP_001268109.1; NM_001281180.1.
DR   RefSeq; XP_019080193.1; XM_019224648.1. [Q8LLR2-1]
DR   RefSeq; XP_019080194.1; XM_019224649.1. [Q8LLR2-2]
DR   AlphaFoldDB; Q8LLR2; -.
DR   SMR; Q8LLR2; -.
DR   STRING; 29760.VIT_14s0083g01050.t01; -.
DR   EnsemblPlants; Vitvi14g01344_t001; Vitvi14g01344_P001; Vitvi14g01344. [Q8LLR2-1]
DR   EnsemblPlants; Vitvi14g01344_t002; Vitvi14g01344_P002; Vitvi14g01344. [Q8LLR2-2]
DR   GeneID; 100232867; -.
DR   Gramene; Vitvi14g01344_t001; Vitvi14g01344_P001; Vitvi14g01344. [Q8LLR2-1]
DR   Gramene; Vitvi14g01344_t002; Vitvi14g01344_P002; Vitvi14g01344. [Q8LLR2-2]
DR   KEGG; vvi:100232867; -.
DR   eggNOG; KOG0014; Eukaryota.
DR   HOGENOM; CLU_053053_0_2_1; -.
DR   OMA; FRSSWAC; -.
DR   OrthoDB; 1039681at2759; -.
DR   Proteomes; UP000009183; Chromosome 14.
DR   ExpressionAtlas; Q8LLR2; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0009908; P:flower development; IEA:UniProtKB-KW.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00265; MADS_MEF2_like; 1.
DR   Gene3D; 3.40.1810.10; -; 1.
DR   InterPro; IPR033896; MADS_MEF2-like.
DR   InterPro; IPR002487; TF_Kbox.
DR   InterPro; IPR002100; TF_MADSbox.
DR   InterPro; IPR036879; TF_MADSbox_sf.
DR   Pfam; PF01486; K-box; 1.
DR   Pfam; PF00319; SRF-TF; 1.
DR   PRINTS; PR00404; MADSDOMAIN.
DR   SMART; SM00432; MADS; 1.
DR   SUPFAM; SSF55455; SSF55455; 1.
DR   PROSITE; PS51297; K_BOX; 1.
DR   PROSITE; PS00350; MADS_BOX_1; 1.
DR   PROSITE; PS50066; MADS_BOX_2; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; DNA-binding; Flowering; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..244
FT                   /note="Agamous-like MADS-box protein MADS2"
FT                   /id="PRO_0000447290"
FT   DOMAIN          1..61
FT                   /note="MADS-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00251"
FT   DOMAIN          88..178
FT                   /note="K-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00629"
FT   VAR_SEQ         89
FT                   /note="Missing (in isoform 2)"
FT                   /id="VSP_060174"
FT   CONFLICT        104
FT                   /note="S -> A (in Ref. 1; AAM21342)"
SQ   SEQUENCE   244 AA;  27891 MW;  395F7D3991CBE594 CRC64;
     MGRGRVELKR IENKINRQVT FAKRRNGLLK KAYELSVLCD AEVALIIFST RGKLYEFCSS
     SSMLKTLERY QKCSYGAVEV SRPSKELEQS SYREYLKLKS KFESLQRTQR NLLGEDLGPL
     NTKELEQLER QLETSLKQVR STKTQFMLDQ LSDLQNKEQV LVESNKALTR KLDEISVKNH
     LQLSWESGEQ SMPYGHQQAQ SQGFFQPLEC NPTLQIGYNP AGSSQLSAPS NAQNVNGFIP
     GWML