MAE2_SCHPO
ID MAE2_SCHPO Reviewed; 431 AA.
AC O59815;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 25-MAY-2022, entry version 104.
DE RecName: Full=Putative malic acid transport protein;
DE AltName: Full=Malate permease;
GN ORFNames=SPCC794.06;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the tellurite-resistance/dicarboxylate
CC transporter (TDT) family. {ECO:0000305}.
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DR EMBL; CU329672; CAA19133.1; -; Genomic_DNA.
DR PIR; T41614; T41614.
DR RefSeq; NP_587754.1; NM_001022747.2.
DR AlphaFoldDB; O59815; -.
DR SMR; O59815; -.
DR BioGRID; 275998; 1.
DR STRING; 4896.SPCC794.06.1; -.
DR MaxQB; O59815; -.
DR PaxDb; O59815; -.
DR EnsemblFungi; SPCC794.06.1; SPCC794.06.1:pep; SPCC794.06.
DR GeneID; 2539435; -.
DR KEGG; spo:SPCC794.06; -.
DR PomBase; SPCC794.06; -.
DR VEuPathDB; FungiDB:SPCC794.06; -.
DR eggNOG; ENOG502QV03; Eukaryota.
DR HOGENOM; CLU_030057_2_0_1; -.
DR InParanoid; O59815; -.
DR OMA; IFPCMIC; -.
DR PhylomeDB; O59815; -.
DR PRO; PR:O59815; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015140; F:malate transmembrane transporter activity; IEA:InterPro.
DR CDD; cd09317; TDT_Mae1_like; 1.
DR Gene3D; 1.50.10.150; -; 1.
DR InterPro; IPR030185; Mae1.
DR InterPro; IPR004695; SLAC1/Mae1/Ssu1/TehA.
DR InterPro; IPR038665; Voltage-dep_anion_channel_sf.
DR PANTHER; PTHR31162; PTHR31162; 1.
DR Pfam; PF03595; SLAC1; 1.
PE 3: Inferred from homology;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..431
FT /note="Putative malic acid transport protein"
FT /id="PRO_0000310766"
FT TRANSMEM 30..50
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 62..82
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..121
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 136..156
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 167..187
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 201..221
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 284..304
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 318..338
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 346..366
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 402..431
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 402..423
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 431 AA; 48840 MW; 402D8481B29F621F CRC64;
MDIVKQRYHE LFDLRVRGPR MKMADRLEHF TWAWFASAMG TGGIGMVTSL YHFRFYGLNT
LGKIIFIFQL SILTLYICCI TFRFIRYPGT LSKTWKNPSE VLFMPTALLA IATSISNLYP
YAFPYTGEWM VWLIRILYWI FVAVACIFVI SLFYSLFHAH PFRINTIIPA LVLPIFPCMI
CGVIASAIVE SQPARQAKNM VVAGIAFQGL GFWIYIIVYA VNMCRFFTVG LQPAADRPGM
FILVSPPSFT GLTLLDLAFG AKAKRPYIFV GDNSSEYLEF VATFMALFMI GLGIFNFCLA
FVSVVAGFCT RQRIKFKVSW FAMIFANVGL VMDVQELGRA IDSKAVCIVG QVCGVTITIV
WIILILLTLR AVYVQELLYP GKDEDIDTIL PNVLEYYRHL EEEEKDEAER SKRKAEESDG
KTTRELTSGG L
