ID   MAEL_AEDAE              Reviewed;         520 AA.
AC   Q16YA8;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Protein maelstrom homolog;
GN   Name=mael; ORFNames=AAEL008595;
OS   Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7159;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LVPib12;
RX   PubMed=17510324; DOI=10.1126/science.1138878;
RA   Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA   Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA   Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA   Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA   Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA   Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA   El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA   Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA   Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA   Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA   Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA   Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA   Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA   Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA   Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA   Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA   Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT   "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL   Science 316:1718-1723(2007).
CC   -!- FUNCTION: Plays a central role during gametogenesis by repressing
CC       transposable elements and preventing their mobilization, which is
CC       essential for the germline integrity. Probably acts via the piRNA
CC       metabolic process, which mediates the repression of transposable
CC       elements during meiosis by forming complexes composed of piRNAs and
CC       Piwi proteins and governs the repression of transposons (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Component of the meiotic
CC       nuage, also named P granule, a germ-cell-specific organelle required to
CC       repress transposon activity during meiosis. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the maelstrom family. {ECO:0000305}.
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DR   EMBL; CH477519; EAT39618.1; -; Genomic_DNA.
DR   EMBL; CH477519; EAT39619.1; -; Genomic_DNA.
DR   RefSeq; XP_001653339.1; XM_001653289.1.
DR   RefSeq; XP_001653340.1; XM_001653290.1.
DR   AlphaFoldDB; Q16YA8; -.
DR   SMR; Q16YA8; -.
DR   STRING; 7159.AAEL008595-PA; -.
DR   PRIDE; Q16YA8; -.
DR   GeneID; 5570832; -.
DR   KEGG; aag:5570832; -.
DR   VEuPathDB; VectorBase:AAEL008595; -.
DR   eggNOG; ENOG502QTQB; Eukaryota.
DR   HOGENOM; CLU_030062_0_0_1; -.
DR   InParanoid; Q16YA8; -.
DR   OMA; NADTTLC; -.
DR   OrthoDB; 859881at2759; -.
DR   PhylomeDB; Q16YA8; -.
DR   Proteomes; UP000008820; Chromosome 2.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0031047; P:gene silencing by RNA; IEA:UniProtKB-KW.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0060964; P:regulation of miRNA-mediated gene silencing; IEA:InterPro.
DR   Gene3D; 1.10.30.10; -; 1.
DR   InterPro; IPR009071; HMG_box_dom.
DR   InterPro; IPR036910; HMG_box_dom_sf.
DR   InterPro; IPR024970; Maelstrom.
DR   InterPro; IPR039259; Protein_maelstrom.
DR   PANTHER; PTHR21358; PTHR21358; 1.
DR   Pfam; PF09011; HMG_box_2; 1.
DR   Pfam; PF13017; Maelstrom; 1.
DR   SUPFAM; SSF47095; SSF47095; 1.
DR   PROSITE; PS50118; HMG_BOX_2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Developmental protein; Differentiation; DNA-binding; Meiosis;
KW   Nucleus; Reference proteome; RNA-mediated gene silencing.
FT   CHAIN           1..520
FT                   /note="Protein maelstrom homolog"
FT                   /id="PRO_0000367293"
FT   DNA_BIND        4..75
FT                   /note="HMG box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT   REGION          436..455
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   520 AA;  58441 MW;  06A1487DD736D66A CRC64;
     MPKKPAAKGP FFFFMLEFRR REESRGKSFP GGMDQVMREA GPHWNQLNEA EREVYKDRAK
     SYKELPKQNY GEKYTAQGIA FSQVEMEKQQ LLKKHETIRK TISEMIQTAV LNNALEKLEV
     FFMSCNYFCK TSTEAFVPAE IALIKYNLEL GVLDKLHELI NPVRLPLGLA HEALTYSEQT
     HELPTPPNAM GETDFYTVLQ KILSFTDYNS KPHKKLAIMT DAKEVPVIES LLSQLNDDVK
     LEYQFLVIPL GEFFFHLKRA TEKYGLDICT FPTKTVADIL LKKDAYEYTS GIACDFHEKL
     GNQRFCALSK VVRWSYIISD NCCLDLSIDL IAGRHLPSNA DTTLCSDLYE TTSKTNQSQS
     DGMSFVSSSE LTHFTLPKIQ KVQSKSAFRS VEDKNGSVIY SSRTVPKKDV KTETTEPHAP
     INPFYMVDGN DSVYAPSYPT KSNGTRPGTS YNPFSRQKKL DEVREPHGLD VKGKGRGTLL
     VTANNSFSSM LKGAGRGSGL FAGLSSVGSN SSVRLSDDEN