ID   MAEL_CULQU              Reviewed;         512 AA.
AC   B0W2W6;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Protein maelstrom homolog;
GN   Name=mael; ORFNames=CPIJ001566;
OS   Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Culicini; Culex; Culex.
OX   NCBI_TaxID=7176;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JHB;
RG   The Broad Institute Genome Sequencing Platform;
RA   Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.D.,
RA   Hannick L.I., Megy K., O'Leary S.B., Pearson M., Haas B.J., Mauceli E.,
RA   Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA   Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA   Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA   Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA   Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA   Fraser-Liggett C.M., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT   "Annotation of Culex pipiens quinquefasciatus.";
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a central role during gametogenesis by repressing
CC       transposable elements and preventing their mobilization, which is
CC       essential for the germline integrity. Probably acts via the piRNA
CC       metabolic process, which mediates the repression of transposable
CC       elements during meiosis by forming complexes composed of piRNAs and
CC       Piwi proteins and governs the repression of transposons (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Component of the meiotic
CC       nuage, also named P granule, a germ-cell-specific organelle required to
CC       repress transposon activity during meiosis. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the maelstrom family. {ECO:0000305}.
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DR   EMBL; DS231829; EDS30325.1; -; Genomic_DNA.
DR   RefSeq; XP_001843050.1; XM_001842998.1.
DR   AlphaFoldDB; B0W2W6; -.
DR   SMR; B0W2W6; -.
DR   STRING; 7176.CPIJ001566-PA; -.
DR   PRIDE; B0W2W6; -.
DR   EnsemblMetazoa; XM_001842998.2; XP_001843050.1; LOC6032454.
DR   GeneID; 6032454; -.
DR   KEGG; cqu:CpipJ_CPIJ001566; -.
DR   VEuPathDB; VectorBase:CPIJ001566; -.
DR   VEuPathDB; VectorBase:CQUJHB008892; -.
DR   eggNOG; ENOG502QTQB; Eukaryota.
DR   HOGENOM; CLU_030062_0_0_1; -.
DR   InParanoid; B0W2W6; -.
DR   OMA; YANIVEY; -.
DR   OrthoDB; 859881at2759; -.
DR   PhylomeDB; B0W2W6; -.
DR   Proteomes; UP000002320; Partially assembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0031047; P:gene silencing by RNA; IEA:UniProtKB-KW.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0060964; P:regulation of miRNA-mediated gene silencing; IEA:InterPro.
DR   Gene3D; 1.10.30.10; -; 1.
DR   InterPro; IPR009071; HMG_box_dom.
DR   InterPro; IPR036910; HMG_box_dom_sf.
DR   InterPro; IPR024970; Maelstrom.
DR   InterPro; IPR039259; Protein_maelstrom.
DR   PANTHER; PTHR21358; PTHR21358; 1.
DR   Pfam; PF09011; HMG_box_2; 1.
DR   Pfam; PF13017; Maelstrom; 1.
DR   SUPFAM; SSF47095; SSF47095; 1.
DR   PROSITE; PS50118; HMG_BOX_2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Developmental protein; Differentiation; DNA-binding; Meiosis;
KW   Nucleus; Reference proteome; RNA-mediated gene silencing.
FT   CHAIN           1..512
FT                   /note="Protein maelstrom homolog"
FT                   /id="PRO_0000367294"
FT   DNA_BIND        9..75
FT                   /note="HMG box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT   REGION          48..72
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          360..421
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          439..465
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        360..374
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        387..421
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        449..463
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   512 AA;  56693 MW;  959B02BB6B135F00 CRC64;
     MPKKNKPAAK GPFYFFMMEF KEQEEAAGYR FSGLAEVTEK AGPHWEKLAP HEREPYNQRA
     KQNKANPKEA GGYGERYTAQ GKPFSQVQAE AAKRRQLEEQ IQKRIVEMIQ TASANNALGE
     LEVYFVSCNY FCVSLSGEYV PAELAIIKYS LNDGVMDSLN VLINPTDLPL GMALDAKTHS
     SSTHQLPVPP DALGEANYEK ILRQILKFFK NTSGSKVVPP IFTWNKDIPM VDSILRGILE
     ATDLDYVKFS ILPLIDFFYN LKLATEDYGL DIKTFPSIHL AKALLEKDVY AYTAGIACDV
     HEQLNNQVAC ALSRVVRWAY VISDSCCLDV GIEMEKGRHL PHNMTTLSDI TGTVSALSSR
     MSKLTTTSDN NRSKMSRPRS TDRTDRDVTT TTIYSSRAGT VTGKPSTIVP QQPASSGGTR
     AANDTFNTTN PFYAMQMAQS ANRSPTKKNP WSRENKLTEV RDPQSDTETS MLMLAPVAGR
     GRGTLARMNA AGRGRAQDLC TTVKTVGRGH LN