MAEL_DROYA
ID MAEL_DROYA Reviewed; 465 AA.
AC B4PIP5; Q71D64;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAR-2009, sequence version 2.
DT 03-AUG-2022, entry version 62.
DE RecName: Full=Protein maelstrom;
GN Name=mael; ORFNames=GE22634;
OS Drosophila yakuba (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7245;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tai18E2 / Tucson 14021-0261.01;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 20-465.
RX PubMed=14525923; DOI=10.1101/gr.1311003;
RA Domazet-Loso T., Tautz D.;
RT "An evolutionary analysis of orphan genes in Drosophila.";
RL Genome Res. 13:2213-2219(2003).
CC -!- FUNCTION: Involved both in the piRNA and miRNA metabolic processes. As
CC a component of the meiotic nuage, plays a central role during oogenesis
CC by repressing transposable elements and preventing their mobilization,
CC which is essential for the germline integrity. Repression of
CC transposable elements is mediated via the piRNA metabolic process,
CC which mediates the repression of transposable elements during meiosis
CC by forming complexes composed of piRNAs and Piwi proteins and governs
CC the repression of transposons. As a nuclear component, it is required
CC for proper differentiation in the germline stem cell (GSC) lineage by
CC repressing microRNA-7 (miR-7), thereby acting as an indirect regulator
CC of bag-of-marbles (Bam). Acts by binding to the promoter of miR-7 gene
CC and repressing its expression; miR-7 repression alleviates the Bam
CC repression by miR-7, thereby allowing differentiation in the germline
CC stem cell (GSC) lineage (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Component of the meiotic
CC nuage, also named P granule, a germ-cell-specific organelle required to
CC repress transposon activity during meiosis. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the maelstrom family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EDW95553.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; CM000159; EDW95553.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AF532006; AAQ09905.1; -; mRNA.
DR RefSeq; XP_002095841.2; XM_002095805.2.
DR RefSeq; XP_015051063.1; XM_015195577.1.
DR RefSeq; XP_015051064.1; XM_015195578.1.
DR RefSeq; XP_015051065.1; XM_015195579.1.
DR RefSeq; XP_015051066.1; XM_015195580.1.
DR RefSeq; XP_015051067.1; XM_015195581.1.
DR RefSeq; XP_015051068.1; XM_015195582.1.
DR RefSeq; XP_015051069.1; XM_015195583.1.
DR RefSeq; XP_015051070.1; XM_015195584.1.
DR RefSeq; XP_015051071.1; XM_015195585.1.
DR RefSeq; XP_015051072.1; XM_015195586.1.
DR AlphaFoldDB; B4PIP5; -.
DR SMR; B4PIP5; -.
DR STRING; 7245.FBpp0267644; -.
DR EnsemblMetazoa; FBtr0393059; FBpp0352468; FBgn0067951.
DR EnsemblMetazoa; FBtr0394889; FBpp0354175; FBgn0067951.
DR EnsemblMetazoa; FBtr0396005; FBpp0355229; FBgn0067951.
DR EnsemblMetazoa; FBtr0396382; FBpp0355579; FBgn0067951.
DR EnsemblMetazoa; FBtr0397549; FBpp0356678; FBgn0067951.
DR EnsemblMetazoa; FBtr0398346; FBpp0357438; FBgn0067951.
DR EnsemblMetazoa; FBtr0399397; FBpp0358423; FBgn0067951.
DR EnsemblMetazoa; FBtr0402874; FBpp0361694; FBgn0067951.
DR EnsemblMetazoa; FBtr0403366; FBpp0362148; FBgn0067951.
DR EnsemblMetazoa; FBtr0404506; FBpp0363211; FBgn0067951.
DR EnsemblMetazoa; FBtr0405164; FBpp0363826; FBgn0067951.
DR GeneID; 6535179; -.
DR eggNOG; ENOG502QTQB; Eukaryota.
DR OrthoDB; 859881at2759; -.
DR Proteomes; UP000002282; Chromosome 3L.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0043186; C:P granule; ISS:UniProtKB.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; ISS:UniProtKB.
DR GO; GO:0031047; P:gene silencing by RNA; ISS:UniProtKB.
DR GO; GO:0030718; P:germ-line stem cell population maintenance; ISS:UniProtKB.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0048477; P:oogenesis; IEA:UniProtKB-KW.
DR GO; GO:0034587; P:piRNA metabolic process; ISS:UniProtKB.
DR GO; GO:0060964; P:regulation of miRNA-mediated gene silencing; ISS:UniProtKB.
DR GO; GO:0007283; P:spermatogenesis; ISS:UniProtKB.
DR Gene3D; 1.10.30.10; -; 1.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR024970; Maelstrom.
DR InterPro; IPR039259; Protein_maelstrom.
DR PANTHER; PTHR21358; PTHR21358; 1.
DR Pfam; PF13017; Maelstrom; 1.
DR SUPFAM; SSF47095; SSF47095; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Developmental protein; Differentiation; DNA-binding; Meiosis;
KW Nucleus; Oogenesis; Repressor; RNA-mediated gene silencing; Transcription;
KW Transcription regulation.
FT CHAIN 1..465
FT /note="Protein maelstrom"
FT /id="PRO_0000367309"
FT DNA_BIND 2..69
FT /note="HMG box"
FT REGION 415..440
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 418..434
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 76
FT /note="A -> T (in Ref. 2; AAQ09905)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 465 AA; 52343 MW; 9482F0ACA544E54B CRC64;
MAPKKHSGFM MFVNEWRNHN AEGRRMTLAQ AVSHCGTIWE KMTTQQRGPY NSGAKDADVA
DRGKRERLNC YGQGIAQVDL AHKEAAESLM HMKRTTERLV INAKKSYDLE NAKFVFATFN
YFTKALTTDV YVPAEFAACE YSLKEGVRSI YSTMIDPGQI IFGQGSDALH HSSTTHDLPL
PPNALGEKNM AKLYRNIVCY LTKCQGADKP LIVFTPTENI AMVNSCFRYL ECEDDSGDGG
RKIQVFDIQY LLFILKKAVM DVAGLNDEKI NKFVTDAFFK KDFFEFTSGI ACQYHEDNDR
TKYCTQSMVT RWAYTFSDFM CGDLAITVQP GKHIPAETKP NYRIICSDAS SLAHESSFES
FYSCPGSRVK KETQSEDFSL SSSQISVASR SYTPTDHTSF TTDLTKVCEF PSLGMRKSSK
HTGPSVSTQR ERNAGAWNLP AHSRSIQKYS DNDFSVTDSV RKLKN
