ID   MAEL_MACFA              Reviewed;         434 AA.
AC   Q4R786;
DT   18-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Protein maelstrom homolog;
GN   Name=MAEL; ORFNames=QtsA-15923;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a central role during spermatogenesis by repressing
CC       transposable elements and preventing their mobilization, which is
CC       essential for the germline integrity. Acts via the piRNA metabolic
CC       process, which mediates the repression of transposable elements during
CC       meiosis by forming complexes composed of piRNAs and Piwi proteins and
CC       governs the methylation and subsequent repression of transposons. Its
CC       association with piP-bodies suggests a participation in the secondary
CC       piRNAs metabolic process. Required for the localization of germ-cell
CC       factors to the meiotic nuage (By similarity).
CC       {ECO:0000250|UniProtKB:Q8BVN9}.
CC   -!- SUBUNIT: Interacts with SMARCB1, SIN3B and DDX4. Interacts with piRNA-
CC       associated proteins TDRD1, PIWIL1 and PIWIL2 (By similarity). Interacts
CC       with TEX19 (By similarity). {ECO:0000250|UniProtKB:Q8BVN9}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8BVN9}. Nucleus
CC       {ECO:0000250|UniProtKB:Q8BVN9}. Note=Component of the meiotic nuage,
CC       also named P granule, a germ-cell-specific organelle required to
CC       repress transposon activity during meiosis. Specifically localizes to
CC       piP-bodies, a subset of the nuage which contains secondary piRNAs (By
CC       similarity). {ECO:0000250|UniProtKB:Q8BVN9}.
CC   -!- SIMILARITY: Belongs to the maelstrom family. {ECO:0000305}.
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DR   EMBL; AB168935; BAE01036.1; -; mRNA.
DR   RefSeq; NP_001306450.1; NM_001319521.1.
DR   AlphaFoldDB; Q4R786; -.
DR   BMRB; Q4R786; -.
DR   SMR; Q4R786; -.
DR   STRING; 9541.XP_005539921.1; -.
DR   GeneID; 102146583; -.
DR   CTD; 84944; -.
DR   VEuPathDB; HostDB:ENSMFAG00000040593; -.
DR   eggNOG; ENOG502QTQB; Eukaryota.
DR   OMA; GARNAYY; -.
DR   OrthoDB; 859881at2759; -.
DR   Proteomes; UP000233100; Chromosome 1.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0043186; C:P granule; ISS:UniProtKB.
DR   GO; GO:0071547; C:piP-body; ISS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0043046; P:DNA methylation involved in gamete generation; ISS:UniProtKB.
DR   GO; GO:0031047; P:gene silencing by RNA; ISS:UniProtKB.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0034587; P:piRNA metabolic process; ISS:UniProtKB.
DR   GO; GO:0060964; P:regulation of miRNA-mediated gene silencing; IEA:InterPro.
DR   GO; GO:0007283; P:spermatogenesis; ISS:UniProtKB.
DR   Gene3D; 1.10.30.10; -; 1.
DR   InterPro; IPR009071; HMG_box_dom.
DR   InterPro; IPR036910; HMG_box_dom_sf.
DR   InterPro; IPR024970; Maelstrom.
DR   InterPro; IPR039259; Protein_maelstrom.
DR   PANTHER; PTHR21358; PTHR21358; 1.
DR   Pfam; PF09011; HMG_box_2; 1.
DR   Pfam; PF13017; Maelstrom; 1.
DR   SUPFAM; SSF47095; SSF47095; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Developmental protein; Differentiation; DNA-binding; Meiosis;
KW   Nucleus; Reference proteome; RNA-mediated gene silencing; Spermatogenesis.
FT   CHAIN           1..434
FT                   /note="Protein maelstrom homolog"
FT                   /id="PRO_0000232502"
FT   DNA_BIND        4..73
FT                   /note="HMG box"
FT   REGION          62..94
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          357..385
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   434 AA;  49168 MW;  067245B7A89B5527 CRC64;
     MPNRKASRNA YYFFVQEKIP ELRRRGLPVA RVADAIPYCS ADWALLREEE KEKYAEMARE
     WRAAQGKDSG PSEKQKPVFT PLRKPGMLVP KQNVSPPDMS TLSLKGDQAL LGGIFYFLNI
     FSHGELPPHC EQRFLPCEIG CVKYSLQEGI MADFHSFINP GEIPRGFRFH CQAASDSSHK
     IPISNFERGH NQATVLQNLY RFIHPNPGNW PPIYCKSDDR TRVNWCLKHM AKASEIRQDL
     QLLTVEDLVV GIYQQKFLKE PSKTWIRSLL DVAMWDYSSN TRCKWHEEND ILFCALAVCK
     KIAYCISNSL ATLFGIQLTE AHVPLQDYEA SNSVTPKMVV LDAGRYQKLR VGSSGFSHFN
     SANQEQRSNT PIGDYPSRAK ISGQNSSVRG RGITRLLESI SNSSSNIHKF SNCDTSLSSY
     MSQKDGYKSF SSLS