ID   MAEL_XENTR              Reviewed;         415 AA.
AC   Q08D62;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Protein maelstrom homolog;
GN   Name=mael;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a central role during spermatogenesis by repressing
CC       transposable elements and preventing their mobilization, which is
CC       essential for the germline integrity. Acts via the piRNA metabolic
CC       process, which mediates the repression of transposable elements during
CC       meiosis by forming complexes composed of piRNAs and Piwi proteins and
CC       governs the methylation and subsequent repression of transposons. Its
CC       association with piP-bodies suggests a participation in the secondary
CC       piRNAs metabolic process. Required for the localization of germ-cell
CC       factors to the meiotic nuage (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Component of the meiotic
CC       nuage, also named P granule, a germ-cell-specific organelle required to
CC       repress transposon activity during meiosis. Specifically localizes to
CC       piP-bodies, a subset of the nuage which contains secondary piRNAs (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the maelstrom family. {ECO:0000305}.
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DR   EMBL; BC123927; AAI23928.1; -; mRNA.
DR   RefSeq; NP_001072645.1; NM_001079177.1.
DR   AlphaFoldDB; Q08D62; -.
DR   SMR; Q08D62; -.
DR   STRING; 8364.ENSXETP00000045377; -.
DR   PaxDb; Q08D62; -.
DR   DNASU; 780102; -.
DR   Ensembl; ENSXETT00000045377; ENSXETP00000045377; ENSXETG00000027834.
DR   GeneID; 780102; -.
DR   KEGG; xtr:780102; -.
DR   CTD; 84944; -.
DR   Xenbase; XB-GENE-997286; mael.
DR   eggNOG; ENOG502QTQB; Eukaryota.
DR   HOGENOM; CLU_051692_0_0_1; -.
DR   InParanoid; Q08D62; -.
DR   OrthoDB; 859881at2759; -.
DR   Proteomes; UP000008143; Chromosome 2.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000027834; Expressed in testis and 10 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0043186; C:P granule; ISS:UniProtKB.
DR   GO; GO:0071547; C:piP-body; ISS:UniProtKB.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0043046; P:DNA methylation involved in gamete generation; ISS:UniProtKB.
DR   GO; GO:0031047; P:gene silencing by RNA; ISS:UniProtKB.
DR   GO; GO:0007140; P:male meiotic nuclear division; IBA:GO_Central.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IBA:GO_Central.
DR   GO; GO:0034587; P:piRNA metabolic process; ISS:UniProtKB.
DR   GO; GO:0060964; P:regulation of miRNA-mediated gene silencing; IEA:InterPro.
DR   GO; GO:0007283; P:spermatogenesis; ISS:UniProtKB.
DR   Gene3D; 1.10.30.10; -; 1.
DR   InterPro; IPR009071; HMG_box_dom.
DR   InterPro; IPR036910; HMG_box_dom_sf.
DR   InterPro; IPR024970; Maelstrom.
DR   InterPro; IPR039259; Protein_maelstrom.
DR   PANTHER; PTHR21358; PTHR21358; 1.
DR   Pfam; PF09011; HMG_box_2; 1.
DR   Pfam; PF13017; Maelstrom; 1.
DR   SUPFAM; SSF47095; SSF47095; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Developmental protein; Differentiation; DNA-binding; Meiosis;
KW   Nucleus; Reference proteome; RNA-mediated gene silencing; Spermatogenesis.
FT   CHAIN           1..415
FT                   /note="Protein maelstrom homolog"
FT                   /id="PRO_0000367292"
FT   DNA_BIND        4..73
FT                   /note="HMG box"
FT   REGION          367..399
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   415 AA;  47000 MW;  B829FCB4ACAE5591 CRC64;
     MPNKKAARNA YFFFALDMIP ELRRRGLQVS GVREAIPLCS EDWALLSADQ KEAYAEKARL
     LKNDPDSTST YNDGVFGQRK RNATKSSDFS SVGFFQLNDQ RNCVTQRTVP AMNIDISFNK
     NKAPDQHVCY FINIFSHGDM PSLCEQRYVP CEIACVRYSL REGILGSFHD FIDPGELPRG
     FRYHCQSGSA STHQIPISGF ELANSDYHNM FRKLCSFVCP TPCPVVPVYT KANDIYRVDW
     CLQWLANKAG MENHFRVQEV ETLIIKFYQD KLQEEPSRPT VSRLLDVVQW DYSSNTRCKW
     HEDNDMWCCA LASCKKIAYC ISKALASVYG VTLTPAHLPN PERSRNQNSV NPKVVVLDAK
     RFQRVCSSDP KYSTDKSERS SFEPRGVKPY QGPSGGGRGI LRLLETLAAS QNSSG