MAF1_ASHGO
ID MAF1_ASHGO Reviewed; 397 AA.
AC Q757K3;
DT 31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 82.
DE RecName: Full=Repressor of RNA polymerase III transcription MAF1;
GN Name=MAF1; OrderedLocusNames=AER009C;
OS Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS (Yeast) (Eremothecium gossypii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX NCBI_TaxID=284811;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=15001715; DOI=10.1126/science.1095781;
RA Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA Gaffney T.D., Philippsen P.;
RT "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT cerevisiae genome.";
RL Science 304:304-307(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=23749448; DOI=10.1534/g3.112.002881;
RA Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT loci, numerous translocations, lack of transposons, and distinct gene
RT duplications.";
RL G3 (Bethesda) 3:1225-1239(2013).
CC -!- FUNCTION: Mediator of diverse signals that repress RNA polymerase III
CC transcription. Inhibits the de novo assembly of TFIIIB onto DNA (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the MAF1 family. {ECO:0000305}.
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DR EMBL; AE016818; AAS52693.1; -; Genomic_DNA.
DR RefSeq; NP_984869.1; NM_210223.1.
DR AlphaFoldDB; Q757K3; -.
DR STRING; 33169.AAS52693; -.
DR EnsemblFungi; AAS52693; AAS52693; AGOS_AER009C.
DR GeneID; 4621068; -.
DR KEGG; ago:AGOS_AER009C; -.
DR eggNOG; KOG3104; Eukaryota.
DR HOGENOM; CLU_037043_2_1_1; -.
DR InParanoid; Q757K3; -.
DR OMA; INIGPFG; -.
DR Proteomes; UP000000591; Chromosome V.
DR GO; GO:0005737; C:cytoplasm; IEA:EnsemblFungi.
DR GO; GO:0005730; C:nucleolus; IEA:EnsemblFungi.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000994; F:RNA polymerase III core binding; IBA:GO_Central.
DR GO; GO:0016480; P:negative regulation of transcription by RNA polymerase III; IBA:GO_Central.
DR GO; GO:0061587; P:transfer RNA gene-mediated silencing; IEA:EnsemblFungi.
DR Gene3D; 3.40.1000.50; -; 1.
DR InterPro; IPR015257; Maf1.
DR InterPro; IPR038564; Maf1_sf.
DR PANTHER; PTHR22504; PTHR22504; 1.
DR Pfam; PF09174; Maf1; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..397
FT /note="Repressor of RNA polymerase III transcription MAF1"
FT /id="PRO_0000213970"
FT REGION 72..195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 374..397
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 92..131
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 145..195
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 397 AA; 45029 MW; D9C40DF684B55FDC CRC64;
MKFIDELDLE LVNQTLNFET SESKISGGCD IFTTKPVASD KKLYKTIDRH LESLLQENES
YNAAIQQQIE LENKRRDPKQ AGSDCAEPAE DSPTRNANSF WEQKRRMSVS ESPRADTSPL
FKSQKLNDQQ LKELVSHPLE VPGCKSPSNE TSARGVLRRS TSAGSFENNA GSAEQQKRRT
SSIGSAANGT KSPILRRSSF NRETINIGPF GPISETASRR TFAYLIGILN ASYPDHDFAS
LKPTDFVKSS RKQLVSKFEN SIIALGKQPQ EWIWETINAH MDLADCVFYQ YNPQESFLDD
EPGHLWSLMW FMFNKKRKRV AYFYLSAFRV KNPPSTGGSV ALDEYYDSNS KPELREKRRR
LTIEHETNDF EGEYDLTYTS SGDGAVEDED EDMNDAD
