ID   MAF1_DANRE              Reviewed;         247 AA.
AC   Q6PGU2;
DT   31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Repressor of RNA polymerase III transcription MAF1 homolog;
GN   Name=maf1; ORFNames=zgc:63803;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Element of the TORC1 signaling pathway that acts as a
CC       mediator of diverse signals and that represses RNA polymerase III
CC       transcription. Inhibits the de novo assembly of TFIIIB onto DNA (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MAF1 family. {ECO:0000305}.
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DR   EMBL; BC056831; AAH56831.1; -; mRNA.
DR   RefSeq; NP_998606.1; NM_213441.1.
DR   AlphaFoldDB; Q6PGU2; -.
DR   SMR; Q6PGU2; -.
DR   STRING; 7955.ENSDARP00000015577; -.
DR   PaxDb; Q6PGU2; -.
DR   PRIDE; Q6PGU2; -.
DR   DNASU; 406750; -.
DR   Ensembl; ENSDART00000006703; ENSDARP00000015577; ENSDARG00000013122.
DR   GeneID; 406750; -.
DR   KEGG; dre:406750; -.
DR   CTD; 406750; -.
DR   ZFIN; ZDB-GENE-040426-2788; maf1a.
DR   eggNOG; KOG3104; Eukaryota.
DR   GeneTree; ENSGT00390000006896; -.
DR   HOGENOM; CLU_037043_3_1_1; -.
DR   InParanoid; Q6PGU2; -.
DR   OMA; NWVVNSV; -.
DR   OrthoDB; 939345at2759; -.
DR   PhylomeDB; Q6PGU2; -.
DR   TreeFam; TF315149; -.
DR   PRO; PR:Q6PGU2; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 11.
DR   Bgee; ENSDARG00000013122; Expressed in testis and 25 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0000994; F:RNA polymerase III core binding; IBA:GO_Central.
DR   GO; GO:0016480; P:negative regulation of transcription by RNA polymerase III; ISS:UniProtKB.
DR   Gene3D; 3.40.1000.50; -; 2.
DR   InterPro; IPR015257; Maf1.
DR   InterPro; IPR038564; Maf1_sf.
DR   PANTHER; PTHR22504; PTHR22504; 1.
DR   Pfam; PF09174; Maf1; 1.
DR   PIRSF; PIRSF037240; RNA_polIII_Trep_MAF1; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..247
FT                   /note="Repressor of RNA polymerase III transcription MAF1
FT                   homolog"
FT                   /id="PRO_0000213975"
FT   REGION          59..83
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          225..247
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   247 AA;  27874 MW;  7C05622ABEE6887B CRC64;
     MKLLENSSFE AINSLLTIET GDCKIIGRIE SYSCKMAGDD KQMFKQFCQE GQPHVLEALS
     PPQSSGISPN KLSHSLDDGE GPLSDKCSRK TLFYLIATLN ESFRPDYDFS RTKGHDFSKE
     PSVNWVFNAV NSSLSAAAGE AYSHLQPQLW EALDKEISLA ECDIYSYNPD LDSDPYGEEG
     NLWSFNYFFY NKRLKRIVFF TCRSVSLFMA PRDSGIGTEL DLELDEGSYE EEEEGNMDEE
     RYGALCA