ID   MAF1_DICDI              Reviewed;         278 AA.
AC   Q54Y76;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Repressor of RNA polymerase III transcription;
GN   Name=maf1; ORFNames=DDB_G0278673;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Element of the TORC1 signaling pathway that acts as a
CC       mediator of diverse signals and that represses RNA polymerase III
CC       transcription. Inhibits the de novo assembly of TFIIIB onto DNA (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MAF1 family. {ECO:0000305}.
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DR   EMBL; AAFI02000023; EAL68509.1; -; Genomic_DNA.
DR   RefSeq; XP_642326.1; XM_637234.2.
DR   AlphaFoldDB; Q54Y76; -.
DR   SMR; Q54Y76; -.
DR   STRING; 44689.DDB0231092; -.
DR   PaxDb; Q54Y76; -.
DR   EnsemblProtists; EAL68509; EAL68509; DDB_G0278673.
DR   GeneID; 8621532; -.
DR   KEGG; ddi:DDB_G0278673; -.
DR   dictyBase; DDB_G0278673; maf1.
DR   eggNOG; KOG3104; Eukaryota.
DR   HOGENOM; CLU_037043_3_1_1; -.
DR   InParanoid; Q54Y76; -.
DR   OMA; DKVCRKT; -.
DR   PhylomeDB; Q54Y76; -.
DR   Reactome; R-DDI-8943724; Regulation of PTEN gene transcription.
DR   PRO; PR:Q54Y76; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0000994; F:RNA polymerase III core binding; IBA:GO_Central.
DR   GO; GO:0016480; P:negative regulation of transcription by RNA polymerase III; ISS:UniProtKB.
DR   Gene3D; 3.40.1000.50; -; 1.
DR   InterPro; IPR015257; Maf1.
DR   InterPro; IPR038564; Maf1_sf.
DR   PANTHER; PTHR22504; PTHR22504; 1.
DR   Pfam; PF09174; Maf1; 1.
DR   PIRSF; PIRSF037240; RNA_polIII_Trep_MAF1; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..278
FT                   /note="Repressor of RNA polymerase III transcription"
FT                   /id="PRO_0000337197"
FT   REGION          59..114
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   278 AA;  31626 MW;  05E4F2CF1393A427 CRC64;
     MKYIDSLQLI GLNSYLNSID VGDALLMGEL EAYSCKMAGS DKKIYRSLDK ELEELSNTNS
     GAMNITNSNN NTNNNNNNNS NSGSSNNNNN NNNTLSVSMN SPSPTSNISV SPFGPMSNST
     SRKTMIYLIQ LLNLSFPDYD FTDSKPEQFQ KEPSLNLVIN SINANLAGYI KDYYLEFEAK
     LWSTLESEIS LQKCEIYLYK PENGDPFTEN GVLFSFNYFF YNKSLKKIIF FKCRYISKLQ
     ILNDDGSDVK DPLPDQEELD DYYREYYDGD TIDNMEMS