MAF1_SCHPO
ID MAF1_SCHPO Reviewed; 238 AA.
AC O14109; Q92362;
DT 01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 22-SEP-2009, sequence version 5.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Repressor of RNA polymerase III transcription maf1;
GN Name=maf1; ORFNames=N150, SPAC31G5.12c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Nagao K., Arioka M., Kadokura H., Yoda K., Yamasaki M.;
RT "The nucleotide sequence of a 9.1 kb DNA fragment of Schizosaccharomyces
RT pombe chromosome reveals the presence of pad1+/sks1+ gene and three
RT previously unknown open reading frames.";
RL Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [3]
RP FUNCTION, AND INTERACTION WITH BFR1 AND RPC82.
RX PubMed=15590667; DOI=10.1074/jbc.m412375200;
RA Desai N., Lee J., Upadhya R., Chu Y., Moir R.D., Willis I.M.;
RT "Two steps in Maf1-dependent repression of transcription by RNA polymerase
RT III.";
RL J. Biol. Chem. 280:6455-6462(2005).
CC -!- FUNCTION: Mediator of diverse signals that repress RNA polymerase III
CC transcription. Inhibits the de novo assembly of TFIIIB onto DNA.
CC {ECO:0000269|PubMed:15590667}.
CC -!- SUBUNIT: Interacts with TFIIIB subunit brf1 and RNA polymerase III
CC subunit rpc82.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the MAF1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA12706.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; D84656; BAA12706.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CU329670; CAB75348.3; -; Genomic_DNA.
DR PIR; T38629; T38629.
DR RefSeq; NP_594012.2; NM_001019438.3.
DR AlphaFoldDB; O14109; -.
DR SMR; O14109; -.
DR BioGRID; 278858; 13.
DR STRING; 4896.SPAC31G5.12c.1; -.
DR iPTMnet; O14109; -.
DR MaxQB; O14109; -.
DR PaxDb; O14109; -.
DR PRIDE; O14109; -.
DR EnsemblFungi; SPAC31G5.12c.1; SPAC31G5.12c.1:pep; SPAC31G5.12c.
DR GeneID; 2542394; -.
DR KEGG; spo:SPAC31G5.12c; -.
DR PomBase; SPAC31G5.12c; maf1.
DR VEuPathDB; FungiDB:SPAC31G5.12c; -.
DR eggNOG; KOG3104; Eukaryota.
DR HOGENOM; CLU_037043_3_0_1; -.
DR InParanoid; O14109; -.
DR OMA; DKVCRKT; -.
DR PhylomeDB; O14109; -.
DR Reactome; R-SPO-8943724; Regulation of PTEN gene transcription.
DR PRO; PR:O14109; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; ISO:PomBase.
DR GO; GO:0106250; F:DNA-binding transcription repressor activity, RNA polymerase III-specific; EXP:PomBase.
DR GO; GO:0000994; F:RNA polymerase III core binding; IBA:GO_Central.
DR GO; GO:0016480; P:negative regulation of transcription by RNA polymerase III; IDA:PomBase.
DR Gene3D; 3.40.1000.50; -; 1.
DR InterPro; IPR015257; Maf1.
DR InterPro; IPR038564; Maf1_sf.
DR PANTHER; PTHR22504; PTHR22504; 1.
DR Pfam; PF09174; Maf1; 1.
DR PIRSF; PIRSF037240; RNA_polIII_Trep_MAF1; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Nucleus; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..238
FT /note="Repressor of RNA polymerase III transcription maf1"
FT /id="PRO_0000116721"
FT REGION 215..238
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 223..238
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 167
FT /note="D -> V (in Ref. 1; BAA12706)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 238 AA; 26970 MW; E6CB18337D48D53C CRC64;
MKFLELADLD TVNNALSFDA DDCRIRGKCE LYTTKSTNSD KKLFKAIENR CQEDLFALSS
SKSPEYAFSL TQQSPFGPLD QSSSRRTFMY IVATLNASYP DHDFSSLQPT DFYKEPSLSR
VVDSVNSTLN NIGRGRLSVN GIWEIIDRHI NLSDCSVYSY TPDSDSDPYG DDALIWGMSY
FFFNKNMKRM LYLSLHGLGK EVSGRNRYGN DDDSVFTPLA DDAEPSDFDD DWVANMDD
