ID   MAF1_XENLA              Reviewed;         245 AA.
AC   Q7ZWL6;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 53.
DE   RecName: Full=Repressor of RNA polymerase III transcription MAF1 homolog;
GN   Name=maf1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Element of the TORC1 signaling pathway that acts as a
CC       mediator of diverse signals and that represses RNA polymerase III
CC       transcription. Inhibits the de novo assembly of TFIIIB onto DNA (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MAF1 family. {ECO:0000305}.
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DR   EMBL; BC046951; AAH46951.1; -; mRNA.
DR   RefSeq; NP_001080708.1; NM_001087239.1.
DR   AlphaFoldDB; Q7ZWL6; -.
DR   SMR; Q7ZWL6; -.
DR   DNASU; 380400; -.
DR   GeneID; 380400; -.
DR   KEGG; xla:380400; -.
DR   CTD; 380400; -.
DR   Xenbase; XB-GENE-6253630; maf1.L.
DR   OrthoDB; 939345at2759; -.
DR   Proteomes; UP000186698; Chromosome 6L.
DR   Bgee; 380400; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0016480; P:negative regulation of transcription by RNA polymerase III; ISS:UniProtKB.
DR   Gene3D; 3.40.1000.50; -; 2.
DR   InterPro; IPR015257; Maf1.
DR   InterPro; IPR038564; Maf1_sf.
DR   PANTHER; PTHR22504; PTHR22504; 1.
DR   Pfam; PF09174; Maf1; 1.
DR   PIRSF; PIRSF037240; RNA_polIII_Trep_MAF1; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..245
FT                   /note="Repressor of RNA polymerase III transcription MAF1
FT                   homolog"
FT                   /id="PRO_0000337196"
FT   REGION          59..84
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          223..245
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   245 AA;  27567 MW;  47A55ADCB70CE2E5 CRC64;
     MKLLENSHFE AVNSQLCVET GDAHIIGRIE SYSCKMAGDD KHMFKQFCQE GQPHVLEALS
     PPQTGISPSR LGKSQGADEE GPLSDKCSRK TLFYLIATLN ESFRPDYDFS AARAHEFSRE
     PSLNWVVNAV NSSLVSALGD DFTSLRPNLW DAVDEEINLS ECDIYSYNPD LDCDPFGEDG
     NLWSFNYFFY NKKLKRIVFF SCRSISGYTY THCDAGAELD MDLEEEDDED EPSSAAGDRP
     QLMCI