ID   MAFA_XENTR              Reviewed;         289 AA.
AC   Q4U1U2;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Transcription factor MafA;
GN   Name=mafa;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RX   PubMed=15759153; DOI=10.1007/s00427-005-0476-y;
RA   Coolen M., Sii-Felice K., Bronchain O., Mazabraud A., Bourrat F.,
RA   Retaux S., Felder-Schmittbuhl M.-P., Mazan S., Plouhinec J.-L.;
RT   "Phylogenomic analysis and expression patterns of large Maf genes in
RT   Xenopus tropicalis provide new insights into the functional evolution of
RT   the gene family in osteichthyans.";
RL   Dev. Genes Evol. 215:327-339(2005).
CC   -!- FUNCTION: Transcription factor, possibly involved in transcription
CC       regulation during lens development. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978}.
CC   -!- DEVELOPMENTAL STAGE: During embryonic development, expressed in
CC       somites. First detected in stage 24 and remains excluded from the 2-3
CC       caudal-most somites at all studied stages. First detectable in the
CC       developing hindbrain at stage 24. Expressed persists until stage 33. At
CC       stage 43, expressed in the olfactory bulb and thalamus.
CC       {ECO:0000269|PubMed:15759153}.
CC   -!- SIMILARITY: Belongs to the bZIP family. Maf subfamily. {ECO:0000305}.
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DR   EMBL; DQ018730; AAY41823.1; -; mRNA.
DR   RefSeq; NP_001027475.1; NM_001032304.1.
DR   AlphaFoldDB; Q4U1U2; -.
DR   SMR; Q4U1U2; -.
DR   STRING; 8364.ENSXETP00000030440; -.
DR   GeneID; 613050; -.
DR   KEGG; xtr:613050; -.
DR   CTD; 389692; -.
DR   Xenbase; XB-GENE-6086265; mafa.
DR   eggNOG; KOG4196; Eukaryota.
DR   InParanoid; Q4U1U2; -.
DR   OrthoDB; 1395389at2759; -.
DR   Proteomes; UP000008143; Chromosome 6.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0030073; P:insulin secretion; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0009749; P:response to glucose; IBA:GO_Central.
DR   InterPro; IPR004827; bZIP.
DR   InterPro; IPR004826; bZIP_Maf.
DR   InterPro; IPR046347; bZIP_sf.
DR   InterPro; IPR013592; Maf_TF_N.
DR   InterPro; IPR028562; MafA.
DR   InterPro; IPR008917; TF_DNA-bd_sf.
DR   InterPro; IPR024874; Transcription_factor_Maf_fam.
DR   PANTHER; PTHR10129; PTHR10129; 1.
DR   PANTHER; PTHR10129:SF30; PTHR10129:SF30; 1.
DR   Pfam; PF03131; bZIP_Maf; 1.
DR   Pfam; PF08383; Maf_N; 1.
DR   SMART; SM00338; BRLZ; 1.
DR   SUPFAM; SSF47454; SSF47454; 1.
DR   SUPFAM; SSF57959; SSF57959; 1.
DR   PROSITE; PS50217; BZIP; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..289
FT                   /note="Transcription factor MafA"
FT                   /id="PRO_0000320279"
FT   DOMAIN          201..264
FT                   /note="bZIP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT   REGION          52..87
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          126..164
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          201..226
FT                   /note="Basic motif"
FT   REGION          229..250
FT                   /note="Leucine-zipper"
FT   REGION          266..289
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   289 AA;  33146 MW;  45C842BD92710A09 CRC64;
     MASDLAMSAE LPNSPLAIEY VNDFDLMKFE VKKEPPEAER FCHRLPPGSL SSTPISTPCS
     SVPSSPSFCA PSPGAQSGVN PSNPNAANKP QLEDLYWMSN YQHHINPEAL NLTPEDAVEA
     LIGNPHHHHH HHQGYDGFRG QQYPGDEMAP SGHHHQVHHH HHHHNHHLRL EDRFSDEQLV
     SMSVRELNRQ LRGFSKEEVI RLKQKRRTLK NRGYAQSCRY KRVQQRHILE TEKCQLQSQV
     EQLKQEVSRL AKERDLYKDK YEKLASRSFT TRESPPQGNP GKANADFFM