MAFB_DANRE
ID MAFB_DANRE Reviewed; 356 AA.
AC Q98UK5; O73679;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Transcription factor MafB;
DE Short=Maf-B;
DE AltName: Full=Transcription factor Val;
DE AltName: Full=Valentino;
GN Name=mafb; Synonyms=mafba, val;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RX PubMed=9425134; DOI=10.1242/dev.125.3.381;
RA Moens C.B., Cordes S.P., Giorgianni M.W., Barsh G.S., Kimmel C.B.;
RT "Equivalence in the genetic control of hindbrain segmentation in fish and
RT mouse.";
RL Development 125:381-391(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11134968; DOI=10.1093/oxfordjournals.jbchem.a002825;
RA Kajihara M., Kawauchi S., Kobayashi M., Ogino H., Takahashi S., Yasuda K.;
RT "Isolation, characterization, and expression analysis of zebrafish large
RT Mafs.";
RL J. Biochem. 129:139-146(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP FUNCTION.
RX PubMed=9012518; DOI=10.1242/dev.122.12.3981;
RA Moens C.B., Yan Y.-L., Appel B., Force A.G., Kimmel C.B.;
RT "valentino: a zebrafish gene required for normal hindbrain segmentation.";
RL Development 122:3981-3990(1996).
CC -!- FUNCTION: May act as a transcriptional activator or repressor. Involved
CC in neurogenesis. Involved in the development of rhombomeres (r) 5 and 6
CC segments from their common precursor 'proto-segment' in the hindbrain.
CC {ECO:0000269|PubMed:9012518}.
CC -!- SUBUNIT: Homodimer or heterodimer with other bHLH-Zip transcription
CC factors. Binds DNA as a homodimer or a heterodimer (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978}.
CC -!- DEVELOPMENTAL STAGE: Expressed in cells that spans the width of the
CC neuronal plate in the presumptive hindbrain at the end of gastrulation.
CC Expressed in r5- and r6-derived neuronal crest cells at the 14 somite
CC stage. Expressed in r5 and r6 until the 20 somite stage (19 hours).
CC Expressed in Mauthner cells of the r4, in cells of the blood-forming
CC region at the base of the yolk extension, in Rohon-Beard cells in the
CC trunk and tail, in a bilateral patch of cells ventral to the third
CC somite which corresponds to the position of the primordial germ cells
CC at 20 somite stage (19 hours). Expressed in r6 at 24 hours. Expressed
CC in r4 and r5 at 42 hours. {ECO:0000269|PubMed:9425134}.
CC -!- SIMILARITY: Belongs to the bZIP family. Maf subfamily. {ECO:0000305}.
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DR EMBL; AF006641; AAC18821.1; -; mRNA.
DR EMBL; AB006322; BAB21102.1; -; mRNA.
DR EMBL; BC117640; AAI17641.1; -; mRNA.
DR AlphaFoldDB; Q98UK5; -.
DR SMR; Q98UK5; -.
DR STRING; 7955.ENSDARP00000018087; -.
DR PaxDb; Q98UK5; -.
DR Ensembl; ENSDART00000193245; ENSDARP00000152024; ENSDARG00000017121.
DR ZFIN; ZDB-GENE-980526-515; mafba.
DR eggNOG; KOG4196; Eukaryota.
DR GeneTree; ENSGT00940000160486; -.
DR HOGENOM; CLU_063062_0_0_1; -.
DR InParanoid; Q98UK5; -.
DR OMA; ESHQPLH; -.
DR PhylomeDB; Q98UK5; -.
DR TreeFam; TF325689; -.
DR SignaLink; Q98UK5; -.
DR PRO; PR:Q98UK5; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 23.
DR Bgee; ENSDARG00000017121; Expressed in rhombomere 6 and 43 other tissues.
DR ExpressionAtlas; Q98UK5; baseline and differential.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0021742; P:abducens nucleus development; IMP:ZFIN.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IMP:ZFIN.
DR GO; GO:0009880; P:embryonic pattern specification; IMP:ZFIN.
DR GO; GO:0001946; P:lymphangiogenesis; IMP:ZFIN.
DR GO; GO:0039021; P:pronephric glomerulus development; IMP:ZFIN.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0021571; P:rhombomere 5 development; IMP:ZFIN.
DR GO; GO:0021572; P:rhombomere 6 development; IMP:ZFIN.
DR GO; GO:0021654; P:rhombomere boundary formation; IMP:ZFIN.
DR InterPro; IPR004827; bZIP.
DR InterPro; IPR004826; bZIP_Maf.
DR InterPro; IPR046347; bZIP_sf.
DR InterPro; IPR013592; Maf_TF_N.
DR InterPro; IPR028571; MafB.
DR InterPro; IPR008917; TF_DNA-bd_sf.
DR InterPro; IPR024874; Transcription_factor_Maf_fam.
DR PANTHER; PTHR10129; PTHR10129; 1.
DR PANTHER; PTHR10129:SF10; PTHR10129:SF10; 1.
DR Pfam; PF03131; bZIP_Maf; 1.
DR Pfam; PF08383; Maf_N; 1.
DR SMART; SM00338; BRLZ; 1.
DR SUPFAM; SSF47454; SSF47454; 1.
DR SUPFAM; SSF57959; SSF57959; 1.
DR PROSITE; PS50217; BZIP; 1.
PE 2: Evidence at transcript level;
KW Activator; DNA-binding; Nucleus; Reference proteome; Repressor;
KW Transcription; Transcription regulation.
FT CHAIN 1..356
FT /note="Transcription factor MafB"
FT /id="PRO_0000366125"
FT DOMAIN 270..333
FT /note="bZIP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 49..79
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 140..240
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 270..295
FT /note="Basic motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 298..319
FT /note="Leucine-zipper"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT COMPBIAS 149..163
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 211..226
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 356 AA; 40233 MW; DE4C96B62C058865 CRC64;
MSADLAMGPE LPTSPLALEY VNDFDLMKFE VKKEAMAAHD RANIRQCNRL QPQGSVSSTP
ISTPCSSVPS SPSFSPTEQK NHLEELYWMP SGAYPQQIDP QTLSLTPEDA VEALIGATAH
GHPPPPHVQQ QLQAGAFDGY RGAHHHHGHA QQQQQQQPQH HHHQHQYGAI PHHPDDLSGH
PGAHGHHPHH HHHHHHSQDP DSPSPTSPEQ LHHRHHHHHH PHGHPGQQGH HGVGGGLNVE
DRFSDDQLVT MSVRELNRHL RGFTKDEVIR LKQKRRTLKN RGYAQSCRFK RVQQKHLLEN
EKTQLINQVE QLKQEINRLA RERDAYKLKC EKLTGANGFR EAGSTSDNPS SPEFFM
