MAFB_XENLA
ID MAFB_XENLA Reviewed; 313 AA.
AC Q6DE84; Q9PUA6;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Transcription factor MafB;
DE Short=Maf-B;
DE Short=XMafB;
GN Name=mafb;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND DEVELOPMENTAL STAGE.
RC TISSUE=Embryonic head;
RX PubMed=11231068; DOI=10.1016/s0925-4773(00)00585-2;
RA Ishibashi S., Yasuda K.;
RT "Distinct roles of maf genes during Xenopus lens development.";
RL Mech. Dev. 101:155-166(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Spleen;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Acts as a transcriptional activator or repressor. Implicated
CC in the regulation of cell-type specific gene expression and play a role
CC in inductive events during lens development.
CC {ECO:0000269|PubMed:11231068}.
CC -!- SUBUNIT: Homodimer or heterodimer with other bHLH-Zip transcription
CC factors. Binds DNA as a homodimer or a heterodimer (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978}.
CC -!- DEVELOPMENTAL STAGE: Expressed in the anterior neuroectoderm at stage
CC 14. Expressed during the formation of the neural tube in rhombomeres
CC (r) 5 and 6, in the derivative neural crest cells and then in the
CC dorsal half of neural tube of r5 and r6 at stage 24. Expressed in the
CC presumptive blood islands at stages 22 and 24. By stage 28 its
CC expression in r5 disappears, but becomes detectable in r4 at stages 29
CC and 30. Its expression in r6 persists until stages 33 and 34. Expressed
CC through r4 in two bilaterally symmetrical columns of cells in the
CC dorsolateral spinal cord at stage 32. Expressed in developing somites
CC at stages 33 and 34. Expressed in myotomal cells at stage 32. Expressed
CC in the pronephros at stage 28. Expressed in the presumptive lens-
CC forming ectoderm (PLE) at stage 22 and during lens formation. Expressed
CC in the inner (sensorial) layer of PLE, developing lens placode and lens
CC epithelium. Expressed in the anterior part of lens vesicle at stages 32
CC to 34. {ECO:0000269|PubMed:11231068}.
CC -!- SIMILARITY: Belongs to the bZIP family. Maf subfamily. {ECO:0000305}.
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DR EMBL; AF202058; AAF08316.1; -; mRNA.
DR EMBL; BC077255; AAH77255.1; -; mRNA.
DR RefSeq; NP_001083852.1; NM_001090383.1.
DR AlphaFoldDB; Q6DE84; -.
DR SMR; Q6DE84; -.
DR GeneID; 399156; -.
DR KEGG; xla:399156; -.
DR CTD; 399156; -.
DR Xenbase; XB-GENE-6085884; mafb.S.
DR OMA; HQVGHSH; -.
DR OrthoDB; 1395389at2759; -.
DR Proteomes; UP000186698; Chromosome 9_10S.
DR Bgee; 399156; Expressed in spleen and 19 other tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; ISS:UniProtKB.
DR InterPro; IPR004827; bZIP.
DR InterPro; IPR004826; bZIP_Maf.
DR InterPro; IPR046347; bZIP_sf.
DR InterPro; IPR013592; Maf_TF_N.
DR InterPro; IPR028571; MafB.
DR InterPro; IPR008917; TF_DNA-bd_sf.
DR InterPro; IPR024874; Transcription_factor_Maf_fam.
DR PANTHER; PTHR10129; PTHR10129; 1.
DR PANTHER; PTHR10129:SF10; PTHR10129:SF10; 1.
DR Pfam; PF03131; bZIP_Maf; 1.
DR Pfam; PF08383; Maf_N; 1.
DR SMART; SM00338; BRLZ; 1.
DR SUPFAM; SSF47454; SSF47454; 1.
DR SUPFAM; SSF57959; SSF57959; 1.
DR PROSITE; PS50217; BZIP; 1.
PE 2: Evidence at transcript level;
KW Activator; DNA-binding; Nucleus; Reference proteome; Repressor;
KW Transcription; Transcription regulation.
FT CHAIN 1..313
FT /note="Transcription factor MafB"
FT /id="PRO_0000366126"
FT DOMAIN 225..288
FT /note="bZIP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 51..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 151..197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 225..250
FT /note="Basic motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 253..274
FT /note="Leucine-zipper"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 292..313
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 167..197
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 198
FT /note="F -> L (in Ref. 1; AAF08316)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 313 AA; 35749 MW; 7E637A071FFE64F8 CRC64;
MAGELPIATP LPTSPLAMEY LNDFDLMKFD VKKEPLGGRP DRAIRQCNRL QPTGSVSSTP
ISTPCSSVPS SPSFSPTEHK THLDDLYWMS SSSYQHVSPE ALNLTPEDAV EALIGQHQMP
PQLQGYESFR AHHHHHHQNQ HQYQGVHHEE MGLPHHHPHH HQHQHHQTSP SPSGSSSSSQ
QLHHQQQHSS SSAVEDRFSD DQLVSMTVRE LNRHLRGFTK DDVIRLKQKR RTLKNRGYAQ
SCRYKRVQQK HNLEGEKTQL VQQVEQLKQE VSRLARERDA YKIKCEKLAN NNSSNFREAG
STSDNPSSPE FFM
