MAFB_XENTR
ID MAFB_XENTR Reviewed; 316 AA.
AC Q504L8;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 07-JUN-2005, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Transcription factor MafB;
DE Short=Maf-B;
DE Short=XMafB;
GN Name=mafb;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RC TISSUE=Embryo;
RX PubMed=15759153; DOI=10.1007/s00427-005-0476-y;
RA Coolen M., Sii-Felice K., Bronchain O., Mazabraud A., Bourrat F.,
RA Retaux S., Felder-Schmittbuhl M.-P., Mazan S., Plouhinec J.-L.;
RT "Phylogenomic analysis and expression patterns of large Maf genes in
RT Xenopus tropicalis provide new insights into the functional evolution of
RT the gene family in osteichthyans.";
RL Dev. Genes Evol. 215:327-339(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Acts as a transcriptional activator or repressor. Implicated
CC in the regulation of cell-type specific gene expression and play a role
CC in inductive events during lens development (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Homodimer or heterodimer with other bHLH-Zip transcription
CC factors. Binds DNA as a homodimer or a heterodimer (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978}.
CC -!- DEVELOPMENTAL STAGE: Expressed in the somites at stage 19 onwards.
CC Expressed in the developing hindbrain between neural plate at stage 32.
CC Expressed in the ventral blood islands from stage 22 until stage 28.
CC Expressed in the condensing pronephros at stage 24. Expressed in the
CC pronephric tubules at stage 33. Expressed in the presumptive lens-
CC forming ectoderm (PLE) at stage 22 and during lens formation. Expressed
CC in the invaginating placode at stage 28. Expressed in lens epithelia at
CC stage 33. Expressed in the rhombencephalon at least until stage 40.
CC Expressed in the olfactory bulb and the thalamus at stage 43. Expressed
CC in the neural crest cells. {ECO:0000269|PubMed:15759153}.
CC -!- SIMILARITY: Belongs to the bZIP family. Maf subfamily. {ECO:0000305}.
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DR EMBL; DQ018731; AAY41824.1; -; mRNA.
DR EMBL; BC094951; AAH94951.1; -; mRNA.
DR RefSeq; NP_001025694.1; NM_001030523.1.
DR AlphaFoldDB; Q504L8; -.
DR SMR; Q504L8; -.
DR Ensembl; ENSXETT00000071067; ENSXETP00000084662; ENSXETG00000037195.
DR GeneID; 595086; -.
DR KEGG; xtr:595086; -.
DR CTD; 9935; -.
DR Xenbase; XB-GENE-6085859; mafb.
DR InParanoid; Q504L8; -.
DR OrthoDB; 1395389at2759; -.
DR PhylomeDB; Q504L8; -.
DR Proteomes; UP000008143; Chromosome 10.
DR Proteomes; UP000790000; Unplaced.
DR Bgee; ENSXETG00000037195; Expressed in mesonephros and 12 other tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0045637; P:regulation of myeloid cell differentiation; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; ISS:UniProtKB.
DR InterPro; IPR004827; bZIP.
DR InterPro; IPR004826; bZIP_Maf.
DR InterPro; IPR046347; bZIP_sf.
DR InterPro; IPR013592; Maf_TF_N.
DR InterPro; IPR028571; MafB.
DR InterPro; IPR008917; TF_DNA-bd_sf.
DR InterPro; IPR024874; Transcription_factor_Maf_fam.
DR PANTHER; PTHR10129; PTHR10129; 1.
DR PANTHER; PTHR10129:SF10; PTHR10129:SF10; 1.
DR Pfam; PF03131; bZIP_Maf; 1.
DR Pfam; PF08383; Maf_N; 1.
DR SMART; SM00338; BRLZ; 1.
DR SUPFAM; SSF47454; SSF47454; 1.
DR SUPFAM; SSF57959; SSF57959; 1.
DR PROSITE; PS50217; BZIP; 1.
PE 2: Evidence at transcript level;
KW Activator; DNA-binding; Nucleus; Reference proteome; Repressor;
KW Transcription; Transcription regulation.
FT CHAIN 1..316
FT /note="Transcription factor MafB"
FT /id="PRO_0000366127"
FT DOMAIN 231..294
FT /note="bZIP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 40..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 116..204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 231..256
FT /note="Basic motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 259..280
FT /note="Leucine-zipper"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT COMPBIAS 50..78
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 129..145
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 174..204
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 316 AA; 36311 MW; 6F827F9BA5DA1B11 CRC64;
MAGELSIATE LPTSPLAMEY VNDFDLMKFD VKKEPLGGRP DRAIRPCNRL QPTGSVSSTP
ISTPCSSVPS SPSFSPTEQK THMDELYWMT NSYQQVNPEA LNLTPEDAVE ALIGPHQMPP
QMQGYDSFRG HHHHHHNNHH HQNHHQYQGL PHEEMGLPHQ HPHHHHHHHH HQPSPSPSGS
SSSSQQLQNS HQQHQNSSAV EDRFSDDQLV SMSVRELNRH LRGFTKDDVI RLKQKRRTLK
NRGYAQSCRF KRVQQKHHLE NEKTQLIQQV EQLKLEVSRL ARERDAYKIK CEKLANTTFR
EAGSTSDNPS SPEFFM
