ID   MAFF_BOVIN              Reviewed;         172 AA.
AC   A7YY73;
DT   23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Transcription factor MafF;
DE   AltName: Full=V-maf musculoaponeurotic fibrosarcoma oncogene homolog F;
GN   Name=MAFF;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Ascending colon;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Since they lack a putative transactivation domain, the small
CC       Mafs behave as transcriptional repressors when they dimerize among
CC       themselves. However, they seem to serve as transcriptional activators
CC       by dimerizing with other (usually larger) basic-zipper proteins, such
CC       as NFE2L1/NRF1, and recruiting them to specific DNA-binding sites.
CC       Interacts with the upstream promoter region of the oxytocin receptor
CC       gene. May be a transcriptional enhancer in the up-regulation of the
CC       oxytocin receptor gene at parturition. {ECO:0000250|UniProtKB:Q9ULX9}.
CC   -!- SUBUNIT: Monomer and homo- or heterodimer. Interacts with MIP. Forms
CC       high affinity heterodimers with members of the CNC-bZIP family such as
CC       NFE2L1/NRF1. {ECO:0000250|UniProtKB:Q9ULX9}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978}.
CC   -!- SIMILARITY: Belongs to the bZIP family. Maf subfamily. {ECO:0000305}.
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DR   EMBL; BC151584; AAI51585.1; -; mRNA.
DR   RefSeq; NP_001096770.1; NM_001103300.1.
DR   AlphaFoldDB; A7YY73; -.
DR   SMR; A7YY73; -.
DR   STRING; 9913.ENSBTAP00000028574; -.
DR   PaxDb; A7YY73; -.
DR   Ensembl; ENSBTAT00000028574; ENSBTAP00000028574; ENSBTAG00000021435.
DR   GeneID; 617914; -.
DR   KEGG; bta:617914; -.
DR   CTD; 23764; -.
DR   VEuPathDB; HostDB:ENSBTAG00000021435; -.
DR   VGNC; VGNC:31140; MAFF.
DR   eggNOG; KOG4196; Eukaryota.
DR   GeneTree; ENSGT00940000161112; -.
DR   HOGENOM; CLU_112948_0_1_1; -.
DR   InParanoid; A7YY73; -.
DR   OMA; MGENTPH; -.
DR   OrthoDB; 1395389at2759; -.
DR   TreeFam; TF325689; -.
DR   Reactome; R-BTA-983231; Factors involved in megakaryocyte development and platelet production.
DR   Proteomes; UP000009136; Chromosome 5.
DR   Bgee; ENSBTAG00000021435; Expressed in gluteus medius and 102 other tissues.
DR   GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0090575; C:RNA polymerase II transcription regulator complex; IEA:Ensembl.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl.
DR   GO; GO:0045604; P:regulation of epidermal cell differentiation; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0035914; P:skeletal muscle cell differentiation; IEA:Ensembl.
DR   InterPro; IPR004827; bZIP.
DR   InterPro; IPR004826; bZIP_Maf.
DR   InterPro; IPR046347; bZIP_sf.
DR   InterPro; IPR033531; MafF.
DR   InterPro; IPR008917; TF_DNA-bd_sf.
DR   InterPro; IPR024874; Transcription_factor_Maf_fam.
DR   PANTHER; PTHR10129; PTHR10129; 1.
DR   PANTHER; PTHR10129:SF25; PTHR10129:SF25; 1.
DR   Pfam; PF03131; bZIP_Maf; 1.
DR   SMART; SM00338; BRLZ; 1.
DR   SUPFAM; SSF47454; SSF47454; 1.
DR   SUPFAM; SSF57959; SSF57959; 1.
DR   PROSITE; PS50217; BZIP; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Reference proteome; Repressor; Stress response;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..172
FT                   /note="Transcription factor MafF"
FT                   /id="PRO_0000350813"
FT   DOMAIN          51..114
FT                   /note="bZIP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT   REGION          51..76
FT                   /note="Basic motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT   REGION          79..93
FT                   /note="Leucine-zipper"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT   REGION          140..172
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        145..172
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   172 AA;  18231 MW;  092A0A1184B84539 CRC64;
     MSVDPLSSKA LKIKRELSEN TPHLSDEALM GLSVRELNRH LRGLSAEEVT RLKQRRRTLK
     NRGYAASCRV KRVCQKEELQ KQKSELEREV DKLARENAAM RLELDALRGK CEALQGFARS
     VAAARGPAAL VAPASVITIV KSAPSPGPGP APGPGPASGP GPAPGPAPAA CS