ID   MAFF_CHICK              Reviewed;         149 AA.
AC   Q90595;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 146.
DE   RecName: Full=Transcription factor MafF;
DE   AltName: Full=V-maf musculoaponeurotic fibrosarcoma oncogene homolog F;
GN   Name=MAFF;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Fibroblast;
RX   PubMed=8361754;
RA   Fujiwara K.T., Kataoka K., Nishizawa M.;
RT   "Two new members of the maf oncogene family, mafK and mafF, encode nuclear
RT   b-Zip proteins lacking putative trans-activator domain.";
RL   Oncogene 8:2371-2380(1993).
CC   -!- FUNCTION: Since it lacks a putative transactivation domain, it may
CC       behave as a transcriptional repressor when it dimerize among himself.
CC       May also serve as a transcriptional activator by dimerizing with other
CC       (usually larger) basic-zipper proteins and recruiting them to specific
CC       DNA-binding sites. May be involved in the cellular stress response.
CC   -!- SUBUNIT: Monomer and homo- or heterodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- TISSUE SPECIFICITY: Highly expressed in the ovary, lower expression in
CC       the brain, heart and mesenterium.
CC   -!- SIMILARITY: Belongs to the bZIP family. Maf subfamily. {ECO:0000305}.
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DR   EMBL; D16184; BAA03727.1; -; mRNA.
DR   PIR; B56253; B56253.
DR   RefSeq; NP_990088.1; NM_204757.1.
DR   RefSeq; XP_015139935.1; XM_015284449.1.
DR   AlphaFoldDB; Q90595; -.
DR   SMR; Q90595; -.
DR   MINT; Q90595; -.
DR   STRING; 9031.ENSGALP00000020036; -.
DR   PaxDb; Q90595; -.
DR   Ensembl; ENSGALT00000020063; ENSGALP00000020036; ENSGALG00000012277.
DR   Ensembl; ENSGALT00000093539; ENSGALP00000069543; ENSGALG00000012277.
DR   GeneID; 395519; -.
DR   KEGG; gga:395519; -.
DR   CTD; 23764; -.
DR   VEuPathDB; HostDB:geneid_395519; -.
DR   eggNOG; KOG4196; Eukaryota.
DR   GeneTree; ENSGT00940000161112; -.
DR   HOGENOM; CLU_112948_0_0_1; -.
DR   InParanoid; Q90595; -.
DR   OMA; MGENTPH; -.
DR   OrthoDB; 1395389at2759; -.
DR   PhylomeDB; Q90595; -.
DR   TreeFam; TF325689; -.
DR   PRO; PR:Q90595; -.
DR   Proteomes; UP000000539; Chromosome 1.
DR   Bgee; ENSGALG00000012277; Expressed in granulocyte and 14 other tissues.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0045604; P:regulation of epidermal cell differentiation; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR004827; bZIP.
DR   InterPro; IPR004826; bZIP_Maf.
DR   InterPro; IPR046347; bZIP_sf.
DR   InterPro; IPR033531; MafF.
DR   InterPro; IPR008917; TF_DNA-bd_sf.
DR   InterPro; IPR024874; Transcription_factor_Maf_fam.
DR   PANTHER; PTHR10129; PTHR10129; 1.
DR   PANTHER; PTHR10129:SF25; PTHR10129:SF25; 1.
DR   Pfam; PF03131; bZIP_Maf; 1.
DR   SMART; SM00338; BRLZ; 1.
DR   SUPFAM; SSF47454; SSF47454; 1.
DR   SUPFAM; SSF57959; SSF57959; 1.
DR   PROSITE; PS50217; BZIP; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..149
FT                   /note="Transcription factor MafF"
FT                   /id="PRO_0000076499"
FT   DOMAIN          51..114
FT                   /note="bZIP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT   REGION          51..76
FT                   /note="Basic motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT   REGION          79..93
FT                   /note="Leucine-zipper"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
SQ   SEQUENCE   149 AA;  16614 MW;  9BB96A7182E1BCBB CRC64;
     MAADGLSSKA LKVKRELGEN TPLLSDEELM GLSVRELNHH LRGLSKEEVA RLKQRRRTLK
     NRGYAASCRV KRVCQKEELQ KQKMELEWEV DKLARENAAM RLELDTLRGK YEALQGFART
     VAAHGPPAKV ATASVITIVK SGANQAAYS