MAFF_MOUSE
ID MAFF_MOUSE Reviewed; 156 AA.
AC O54791;
DT 20-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1998, sequence version 1.
DT 03-AUG-2022, entry version 165.
DE RecName: Full=Transcription factor MafF;
DE AltName: Full=V-maf musculoaponeurotic fibrosarcoma oncogene homolog F;
GN Name=Maff;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND DEVELOPMENTAL STAGE.
RC STRAIN=129/SvJ;
RX PubMed=10409670; DOI=10.1074/jbc.274.30.21162;
RA Onodera K., Shavit J.A., Motohashi H., Katsuoka F., Akasaka J.-E.,
RA Engel J.D., Yamamoto M.;
RT "Characterization of the murine mafF gene.";
RL J. Biol. Chem. 274:21162-21169(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Since they lack a putative transactivation domain, the small
CC Mafs behave as transcriptional repressors when they dimerize among
CC themselves. However, they seem to serve as transcriptional activators
CC by dimerizing with other (usually larger) basic-zipper proteins, such
CC as NFE2L1/NRF1, and recruiting them to specific DNA-binding sites.
CC Interacts with the upstream promoter region of the oxytocin receptor
CC gene. May be a transcriptional enhancer in the up-regulation of the
CC oxytocin receptor gene at parturition. {ECO:0000250|UniProtKB:Q9ULX9}.
CC -!- SUBUNIT: Monomer and homo- or heterodimer. Interacts with MIP. Forms
CC high affinity heterodimers with members of the CNC-bZIP family such as
CC NFE2L1/NRF1. {ECO:0000250|UniProtKB:Q9ULX9}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978}.
CC -!- TISSUE SPECIFICITY: Highly expressed in the lung, lower expression in
CC the brain, thymus, liver, spleen, intestine, kidney, heart, muscle, and
CC ovary. Not significantly expressed in hematopoietic cells.
CC -!- DEVELOPMENTAL STAGE: Detected at 6.5 dpc in the boundary between the
CC extraembryonic and embryonic regions. At 8.5 dpc, weakly expressed in
CC the future gut, allantois, yolk sac endoderm and the ectoplacental
CC cone. At 9.5 dpc, strong expression in the primordial gut and
CC presumptive fetal liver, in the floorplate of the myelencephalon,
CC neural crest cells, spongiotrophoblasts, and giant cells of the
CC placenta. At 12.5 dpc, detected in hepotocytes, in the outflow tract of
CC the heart in a specific subset of dorsal root ganglia, in the cranial
CC nerve ganglia, in the lung primordium, and in the epithelium of the
CC expiratory tract. In newborn, strongly expressed in keratinocytes, in
CC the cartilage, in bronchial epithelia, and bone membrane.
CC {ECO:0000269|PubMed:10409670}.
CC -!- SIMILARITY: Belongs to the bZIP family. Maf subfamily. {ECO:0000305}.
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DR EMBL; AB009694; BAA24029.1; -; Genomic_DNA.
DR EMBL; BC022952; AAH22952.1; -; mRNA.
DR CCDS; CCDS27638.1; -.
DR RefSeq; NP_001291759.1; NM_001304830.1.
DR RefSeq; NP_034885.1; NM_010755.4.
DR RefSeq; XP_006520609.2; XM_006520546.3.
DR RefSeq; XP_006520613.1; XM_006520550.3.
DR RefSeq; XP_011243786.1; XM_011245484.2.
DR AlphaFoldDB; O54791; -.
DR SMR; O54791; -.
DR BioGRID; 201282; 2.
DR IntAct; O54791; 1.
DR STRING; 10090.ENSMUSP00000094076; -.
DR iPTMnet; O54791; -.
DR PhosphoSitePlus; O54791; -.
DR PaxDb; O54791; -.
DR PeptideAtlas; O54791; -.
DR PRIDE; O54791; -.
DR ProteomicsDB; 295776; -.
DR Antibodypedia; 12337; 161 antibodies from 30 providers.
DR DNASU; 17133; -.
DR Ensembl; ENSMUST00000096350; ENSMUSP00000094076; ENSMUSG00000042622.
DR Ensembl; ENSMUST00000163691; ENSMUSP00000131628; ENSMUSG00000042622.
DR Ensembl; ENSMUST00000229130; ENSMUSP00000154850; ENSMUSG00000042622.
DR GeneID; 17133; -.
DR KEGG; mmu:17133; -.
DR UCSC; uc007wth.2; mouse.
DR CTD; 23764; -.
DR MGI; MGI:96910; Maff.
DR VEuPathDB; HostDB:ENSMUSG00000042622; -.
DR eggNOG; KOG4196; Eukaryota.
DR GeneTree; ENSGT00940000161112; -.
DR HOGENOM; CLU_112948_0_1_1; -.
DR InParanoid; O54791; -.
DR OMA; MGENTPH; -.
DR PhylomeDB; O54791; -.
DR TreeFam; TF325689; -.
DR Reactome; R-MMU-983231; Factors involved in megakaryocyte development and platelet production.
DR BioGRID-ORCS; 17133; 1 hit in 57 CRISPR screens.
DR ChiTaRS; Maff; mouse.
DR PRO; PR:O54791; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; O54791; protein.
DR Bgee; ENSMUSG00000042622; Expressed in aortic valve and 159 other tissues.
DR ExpressionAtlas; O54791; baseline and differential.
DR Genevisible; O54791; MM.
DR GO; GO:0005739; C:mitochondrion; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0090575; C:RNA polymerase II transcription regulator complex; ISO:MGI.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; ISO:MGI.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0001701; P:in utero embryonic development; IGI:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:MGI.
DR GO; GO:0045604; P:regulation of epidermal cell differentiation; IGI:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0035914; P:skeletal muscle cell differentiation; IMP:MGI.
DR InterPro; IPR004827; bZIP.
DR InterPro; IPR004826; bZIP_Maf.
DR InterPro; IPR046347; bZIP_sf.
DR InterPro; IPR033531; MafF.
DR InterPro; IPR008917; TF_DNA-bd_sf.
DR InterPro; IPR024874; Transcription_factor_Maf_fam.
DR PANTHER; PTHR10129; PTHR10129; 1.
DR PANTHER; PTHR10129:SF25; PTHR10129:SF25; 1.
DR Pfam; PF03131; bZIP_Maf; 1.
DR SMART; SM00338; BRLZ; 1.
DR SUPFAM; SSF47454; SSF47454; 1.
DR SUPFAM; SSF57959; SSF57959; 1.
DR PROSITE; PS50217; BZIP; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..156
FT /note="Transcription factor MafF"
FT /id="PRO_0000076498"
FT DOMAIN 51..114
FT /note="bZIP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 51..76
FT /note="Basic motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 79..93
FT /note="Leucine-zipper"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
SQ SEQUENCE 156 AA; 16955 MW; 574DD05499819037 CRC64;
MAVDPLSSKA LKVKRELSEN TPHLSDEALM GLSVRELNRN LRGLSAEEVT RLKQRRRTLK
NRGYAASCRV KRVCQKEELQ KQKSELEREV DKLARENAAM RLELDALRGK CEALQGFARS
VAAARGPAAL VAPASVITIV KSAPGPAPAA DPAPCS
