MAFK_CHICK
ID MAFK_CHICK Reviewed; 156 AA.
AC Q90596;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Transcription factor MafK;
GN Name=MAFK;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Fibroblast;
RX PubMed=8361754;
RA Fujiwara K.T., Kataoka K., Nishizawa M.;
RT "Two new members of the maf oncogene family, mafK and mafF, encode nuclear
RT b-Zip proteins lacking putative trans-activator domain.";
RL Oncogene 8:2371-2380(1993).
CC -!- FUNCTION: Since they lack a putative transactivation domain, the small
CC Mafs behave as transcriptional repressors when they dimerize among
CC themselves. However, they act as transcriptional activators by
CC dimerizing with other (usually larger) basic-zipper proteins and
CC recruiting them to specific DNA-binding sites. Small Maf proteins
CC heterodimerize with Fos and may act as competitive repressors of the
CC NF-E2 transcription factor. {ECO:0000269|PubMed:8361754}.
CC -!- SUBUNIT: Homodimer or heterodimer. {ECO:0000269|PubMed:8361754}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:8361754}.
CC -!- SIMILARITY: Belongs to the bZIP family. Maf subfamily. {ECO:0000305}.
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DR EMBL; D16187; BAA03728.1; -; mRNA.
DR PIR; A56253; A56253.
DR RefSeq; NP_990087.1; NM_204756.1.
DR RefSeq; XP_015149619.1; XM_015294133.1.
DR RefSeq; XP_015149620.1; XM_015294134.1.
DR AlphaFoldDB; Q90596; -.
DR SMR; Q90596; -.
DR MINT; Q90596; -.
DR STRING; 9031.ENSGALP00000006645; -.
DR PaxDb; Q90596; -.
DR Ensembl; ENSGALT00000006656; ENSGALP00000006645; ENSGALG00000004189.
DR Ensembl; ENSGALT00000054791; ENSGALP00000046925; ENSGALG00000004189.
DR Ensembl; ENSGALT00000097062; ENSGALP00000065003; ENSGALG00000004189.
DR GeneID; 395518; -.
DR KEGG; gga:395518; -.
DR CTD; 7975; -.
DR VEuPathDB; HostDB:geneid_395518; -.
DR eggNOG; KOG4196; Eukaryota.
DR GeneTree; ENSGT00940000160044; -.
DR HOGENOM; CLU_112948_0_0_1; -.
DR InParanoid; Q90596; -.
DR OMA; KSANHNS; -.
DR OrthoDB; 1395389at2759; -.
DR PhylomeDB; Q90596; -.
DR TreeFam; TF325689; -.
DR Reactome; R-GGA-9707616; Heme signaling.
DR Reactome; R-GGA-9708530; Regulation of BACH1 activity.
DR PRO; PR:Q90596; -.
DR Proteomes; UP000000539; Chromosome 14.
DR Bgee; ENSGALG00000004189; Expressed in lung and 12 other tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR004827; bZIP.
DR InterPro; IPR004826; bZIP_Maf.
DR InterPro; IPR046347; bZIP_sf.
DR InterPro; IPR028574; MafK.
DR InterPro; IPR008917; TF_DNA-bd_sf.
DR InterPro; IPR024874; Transcription_factor_Maf_fam.
DR PANTHER; PTHR10129; PTHR10129; 1.
DR PANTHER; PTHR10129:SF26; PTHR10129:SF26; 1.
DR Pfam; PF03131; bZIP_Maf; 1.
DR SMART; SM00338; BRLZ; 1.
DR SUPFAM; SSF47454; SSF47454; 1.
DR SUPFAM; SSF57959; SSF57959; 1.
DR PROSITE; PS50217; BZIP; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..156
FT /note="Transcription factor MafK"
FT /id="PRO_0000076505"
FT DOMAIN 51..114
FT /note="bZIP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 51..76
FT /note="Basic motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 79..93
FT /note="Leucine-zipper"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
SQ SEQUENCE 156 AA; 17538 MW; 4F45BCE40DA41C26 CRC64;
MTTNPKPNKA LKVKEESGEN APVLSDDELV SMSVRELNQH LRGLTKEEVI RLKQRRRTLK
NRGYAASCRI KRVTQKEELE RQRVELQQEV EKLARENSSM KLELDALRSK YEALQTFART
VARGPITPTK VATTSVITIV KSAEISSSSV PFSAAS
