ID   MAF_DANRE               Reviewed;         327 AA.
AC   Q98UK4;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Transcription factor Maf;
GN   Name=maf;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RX   PubMed=11134968; DOI=10.1093/oxfordjournals.jbchem.a002825;
RA   Kajihara M., Kawauchi S., Kobayashi M., Ogino H., Takahashi S., Yasuda K.;
RT   "Isolation, characterization, and expression analysis of zebrafish large
RT   Mafs.";
RL   J. Biochem. 129:139-146(2001).
CC   -!- FUNCTION: Acts as a transcriptional activator or repressor.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer or heterodimer. Binds DNA as a homodimer or a
CC       heterodimer (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in the lens fiber cells during
CC       embryogenesis. During somitogenesis expressed in somitic cells (at
CC       protein level). {ECO:0000269|PubMed:11134968}.
CC   -!- SIMILARITY: Belongs to the bZIP family. Maf subfamily. {ECO:0000305}.
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DR   EMBL; AB006323; BAB21103.2; -; mRNA.
DR   RefSeq; NP_001303598.1; NM_001316669.1.
DR   AlphaFoldDB; Q98UK4; -.
DR   SMR; Q98UK4; -.
DR   STRING; 7955.ENSDARP00000101942; -.
DR   GeneID; 100537332; -.
DR   KEGG; dre:100537332; -.
DR   CTD; 9935; -.
DR   ZFIN; ZDB-GENE-141211-38; mafb.
DR   InParanoid; Q98UK4; -.
DR   OrthoDB; 1395389at2759; -.
DR   PhylomeDB; Q98UK4; -.
DR   PRO; PR:Q98UK4; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR004827; bZIP.
DR   InterPro; IPR004826; bZIP_Maf.
DR   InterPro; IPR046347; bZIP_sf.
DR   InterPro; IPR028573; Maf/V-MAF.
DR   InterPro; IPR013592; Maf_TF_N.
DR   InterPro; IPR008917; TF_DNA-bd_sf.
DR   InterPro; IPR024874; Transcription_factor_Maf_fam.
DR   PANTHER; PTHR10129; PTHR10129; 1.
DR   PANTHER; PTHR10129:SF9; PTHR10129:SF9; 1.
DR   Pfam; PF03131; bZIP_Maf; 1.
DR   Pfam; PF08383; Maf_N; 1.
DR   SMART; SM00338; BRLZ; 1.
DR   SUPFAM; SSF47454; SSF47454; 1.
DR   SUPFAM; SSF57959; SSF57959; 1.
DR   PROSITE; PS50217; BZIP; 1.
PE   1: Evidence at protein level;
KW   Activator; DNA-binding; Nucleus; Reference proteome; Repressor;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..327
FT                   /note="Transcription factor Maf"
FT                   /id="PRO_0000364083"
FT   DOMAIN          241..304
FT                   /note="bZIP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT   REGION          54..84
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          167..209
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          241..266
FT                   /note="Basic motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT   REGION          269..290
FT                   /note="Leucine-zipper"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT   REGION          308..327
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        171..189
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   327 AA;  35825 MW;  ABB23A7403858816 CRC64;
     MASELAMSSS DLPTSPLAME YVNDFDLMKF EVKKEPVEPD RSISQCSRLI AGGSLSSTPM
     STPCSSVPPS PSFSAPSPGS GSEQKAHLED FYWMTGYQQQ LNPEALGFSP EDAVEALISS
     SHQLQSFDGY ARGQQFGSAA GAGGAMAGEE MGSAAAVVSA VIAAAAAQNG APHHHHHHHH
     HHPAGHHHHH AAPGAQSNGA SAGHPGHMHL DERFSDEQLV NMSVRELNRQ LRGVSKEEVI
     RLKQKRRTLK NRGYAQSCRY KRVQQRHVLE GEKTQLMQQV DHLKQEISRL VRERDAYKEK
     YEKLISSGFR ENGSSSDNNP SSPEFFM