MAGA1_HUMAN
ID MAGA1_HUMAN Reviewed; 309 AA.
AC P43355; B2RC81; O00346;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 180.
DE RecName: Full=Melanoma-associated antigen 1;
DE AltName: Full=Antigen MZ2-E;
DE AltName: Full=Cancer/testis antigen 1.1;
DE Short=CT1.1;
DE AltName: Full=MAGE-1 antigen;
GN Name=MAGEA1; Synonyms=MAGE1, MAGE1A;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1840703; DOI=10.1126/science.1840703;
RA van der Bruggen P., Traversari C., Chomez P., Lurquin C., De Plaen E.,
RA van den Eynde B., Knuth A., Boon T.;
RT "A gene encoding an antigen recognized by cytolytic T lymphocytes on a
RT human melanoma.";
RL Science 254:1643-1647(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Skin;
RX PubMed=8037761; DOI=10.1006/bbrc.1994.1963;
RA Ding M., Beck R.J., Keller C.J., Fenton R.G.;
RT "Cloning and analysis of MAGE-1-related genes.";
RL Biochem. Biophys. Res. Commun. 202:549-555(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT ALA-32.
RX PubMed=15059299;
RA Wang L.P., Chen H.S., Mei M.H., Qin L.L., Cong X., Fei R., Xu J., Wei L.;
RT "The genetic polymorphism of melanoma-associated antigen 1 in Chinese
RT normal donors and hepatoma patients.";
RL Zhonghua Gan Zang Bing Za Zhi 12:151-155(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ALA-32.
RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA Phelan M., Farmer A.;
RT "Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10854409; DOI=10.1101/gr.10.6.758;
RA Mallon A.-M., Platzer M., Bate R., Gloeckner G., Botcherby M.R.M.,
RA Nordsiek G., Strivens M.A., Kioschis P., Dangel A., Cunningham D.,
RA Straw R.N.A., Weston P., Gilbert M., Fernando S., Goodall K., Hunter G.,
RA Greystrong J.S., Clarke D., Kimberley C., Goerdes M., Blechschmidt K.,
RA Rump A., Hinzmann B., Mundy C.R., Miller W., Poustka A., Herman G.E.,
RA Rhodes M., Denny P., Rosenthal A., Brown S.D.M.;
RT "Comparative genome sequence analysis of the Bpa/Str region in mouse and
RT man.";
RL Genome Res. 10:758-775(2000).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [9]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ALA-32.
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [10]
RP MUTAGENESIS.
RC TISSUE=Blood;
RX PubMed=8113684; DOI=10.1084/jem.179.3.921;
RA Gaugler B., van den Eynde B., van der Bruggen P., Romero P., Gaforio J.J.,
RA De Plaen E., Lethe B.G., Brasseur F., Boon T.;
RT "Human gene MAGE-3 codes for an antigen recognized on a melanoma by
RT autologous cytolytic T lymphocytes.";
RL J. Exp. Med. 179:921-930(1994).
RN [11]
RP SUBCELLULAR LOCATION.
RX PubMed=7927954; DOI=10.1002/ijc.2910590324;
RA Schultz-Thater E., Juretic A., Dellabona P., Luscher U., Siegrist W.,
RA Harder F., Heberer M., Zuber M., Spagnoli G.C.;
RT "MAGE-1 gene product is a cytoplasmic protein.";
RL Int. J. Cancer 59:435-439(1994).
RN [12]
RP FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH SNW1 AND HDCA1.
RX PubMed=15316101; DOI=10.1093/nar/gkh735;
RA Laduron S., Deplus R., Zhou S., Kholmanskikh O., Godelaine D., De Smet C.,
RA Hayward S.D., Fuks F., Boon T., De Plaen E.;
RT "MAGE-A1 interacts with adaptor SKIP and the deacetylase HDAC1 to repress
RT transcription.";
RL Nucleic Acids Res. 32:4340-4350(2004).
RN [13]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-57, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [14]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [15]
RP X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS) OF 161-169 IN COMPLEX WITH HLA CLASS
RP I HISTOCOMPATIBILITY COMPLEX.
RX PubMed=15537658; DOI=10.1074/jbc.m411323200;
RA Hulsmeyer M., Chames P., Hillig R.C., Stanfield R.L., Held G., Coulie P.G.,
RA Alings C., Wille G., Saenger W., Uchanska-Ziegler B., Hoogenboom H.R.,
RA Ziegler A.;
RT "A major histocompatibility complex-peptide-restricted antibody and t cell
RT receptor molecules recognize their target by distinct binding modes:
RT crystal structure of human leukocyte antigen (HLA)-A1-MAGE-A1 in complex
RT with FAB-HYB3.";
RL J. Biol. Chem. 280:2972-2980(2005).
RN [16]
RP X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 161-169 IN COMPLEX WITH HLA CLASS
RP I HISTOCOMPATIBILITY COMPLEX.
RX PubMed=19177349; DOI=10.1002/pro.4;
RA Kumar P., Vahedi-Faridi A., Saenger W., Ziegler A., Uchanska-Ziegler B.;
RT "Conformational changes within the HLA-A1:MAGE-A1 complex induced by
RT binding of a recombinant antibody fragment with TCR-like specificity.";
RL Protein Sci. 18:37-49(2009).
RN [17]
RP VARIANT [LARGE SCALE ANALYSIS] THR-278.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
CC -!- FUNCTION: May be involved in transcriptional regulation through
CC interaction with SNW1 and recruiting histone deactelyase HDAC1. May
CC inhibit notch intracellular domain (NICD) transactivation. May play a
CC role in embryonal development and tumor transformation or aspects of
CC tumor progression. Antigen recognized on a melanoma by autologous
CC cytolytic T-lymphocytes. {ECO:0000269|PubMed:15316101}.
CC -!- SUBUNIT: Interacts with SNW1 and HDCA1. {ECO:0000269|PubMed:15316101,
CC ECO:0000269|PubMed:15537658, ECO:0000269|PubMed:19177349}.
CC -!- INTERACTION:
CC P43355; Q9NYB9-2: ABI2; NbExp=3; IntAct=EBI-740978, EBI-11096309;
CC P43355; Q8IYX8-2: CEP57L1; NbExp=3; IntAct=EBI-740978, EBI-10181988;
CC P43355; Q8N140: EID3; NbExp=3; IntAct=EBI-740978, EBI-744483;
CC P43355; Q13547: HDAC1; NbExp=2; IntAct=EBI-740978, EBI-301834;
CC P43355; Q9NX55: HYPK; NbExp=3; IntAct=EBI-740978, EBI-1048743;
CC P43355; Q9NQG6: MIEF1; NbExp=7; IntAct=EBI-740978, EBI-740987;
CC P43355; Q5JS98: PBX3; NbExp=3; IntAct=EBI-740978, EBI-10244393;
CC P43355; Q9H0T7: RAB17; NbExp=3; IntAct=EBI-740978, EBI-721615;
CC P43355; P06702: S100A9; NbExp=3; IntAct=EBI-740978, EBI-1055001;
CC P43355; A0A0C4DFY0: SELPLG; NbExp=6; IntAct=EBI-740978, EBI-10209116;
CC P43355; P31947: SFN; NbExp=3; IntAct=EBI-740978, EBI-476295;
CC P43355; Q9NR46: SH3GLB2; NbExp=3; IntAct=EBI-740978, EBI-749607;
CC P43355; Q9NUL5: SHFL; NbExp=3; IntAct=EBI-740978, EBI-10313866;
CC P43355; Q13573: SNW1; NbExp=3; IntAct=EBI-740978, EBI-632715;
CC P43355; Q2L6J1: TRIM31; NbExp=3; IntAct=EBI-740978, EBI-10239267;
CC P43355; Q9BZY9: TRIM31; NbExp=4; IntAct=EBI-740978, EBI-747544;
CC P43355; Q8TBZ8: ZNF564; NbExp=4; IntAct=EBI-740978, EBI-10273713;
CC -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
CC -!- TISSUE SPECIFICITY: Expressed in many tumors of several types, such as
CC melanoma, head and neck squamous cell carcinoma, lung carcinoma and
CC breast carcinoma, but not in normal tissues except for testes. Never
CC expressed in kidney tumors, leukemias and lymphomas.
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DR EMBL; M77481; AAA03229.1; -; Genomic_DNA.
DR EMBL; AY148486; AAN62752.1; -; mRNA.
DR EMBL; BT009789; AAP88791.1; -; mRNA.
DR EMBL; AK314979; BAG37478.1; -; mRNA.
DR EMBL; U82670; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471172; EAW72885.1; -; Genomic_DNA.
DR EMBL; BC017555; AAH17555.1; -; mRNA.
DR CCDS; CCDS76051.1; -.
DR PIR; JC2358; JC2358.
DR RefSeq; NP_004979.3; NM_004988.4.
DR PDB; 1W72; X-ray; 2.15 A; C/F=161-169.
DR PDB; 3BO8; X-ray; 1.80 A; C=161-169.
DR PDBsum; 1W72; -.
DR PDBsum; 3BO8; -.
DR AlphaFoldDB; P43355; -.
DR SMR; P43355; -.
DR BioGRID; 110274; 104.
DR CORUM; P43355; -.
DR DIP; DIP-54794N; -.
DR IntAct; P43355; 71.
DR MINT; P43355; -.
DR STRING; 9606.ENSP00000349085; -.
DR iPTMnet; P43355; -.
DR PhosphoSitePlus; P43355; -.
DR BioMuta; MAGEA1; -.
DR DMDM; 1170855; -.
DR EPD; P43355; -.
DR jPOST; P43355; -.
DR MassIVE; P43355; -.
DR MaxQB; P43355; -.
DR PaxDb; P43355; -.
DR PeptideAtlas; P43355; -.
DR PRIDE; P43355; -.
DR ProteomicsDB; 55617; -.
DR ABCD; P43355; 1 sequenced antibody.
DR Antibodypedia; 3622; 647 antibodies from 37 providers.
DR DNASU; 4100; -.
DR Ensembl; ENST00000356661.7; ENSP00000349085.5; ENSG00000198681.7.
DR GeneID; 4100; -.
DR KEGG; hsa:4100; -.
DR MANE-Select; ENST00000356661.7; ENSP00000349085.5; NM_004988.5; NP_004979.3.
DR UCSC; uc004fhf.3; human.
DR CTD; 4100; -.
DR DisGeNET; 4100; -.
DR GeneCards; MAGEA1; -.
DR HGNC; HGNC:6796; MAGEA1.
DR HPA; ENSG00000198681; Tissue enriched (testis).
DR MIM; 300016; gene.
DR neXtProt; NX_P43355; -.
DR OpenTargets; ENSG00000198681; -.
DR PharmGKB; PA30542; -.
DR VEuPathDB; HostDB:ENSG00000198681; -.
DR eggNOG; KOG4562; Eukaryota.
DR GeneTree; ENSGT00940000165830; -.
DR HOGENOM; CLU_039582_1_0_1; -.
DR InParanoid; P43355; -.
DR OMA; SYVLVTC; -.
DR OrthoDB; 1195799at2759; -.
DR PhylomeDB; P43355; -.
DR TreeFam; TF328505; -.
DR PathwayCommons; P43355; -.
DR SignaLink; P43355; -.
DR BioGRID-ORCS; 4100; 14 hits in 703 CRISPR screens.
DR EvolutionaryTrace; P43355; -.
DR GeneWiki; MAGEA1; -.
DR GenomeRNAi; 4100; -.
DR Pharos; P43355; Tbio.
DR PRO; PR:P43355; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; P43355; protein.
DR Bgee; ENSG00000198681; Expressed in right testis and 14 other tissues.
DR Genevisible; P43355; HS.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; TAS:ProtInc.
DR GO; GO:0042826; F:histone deacetylase binding; IDA:UniProtKB.
DR GO; GO:0045746; P:negative regulation of Notch signaling pathway; IDA:UniProtKB.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:UniProtKB.
DR Gene3D; 1.10.10.1200; -; 1.
DR Gene3D; 1.10.10.1210; -; 1.
DR IDEAL; IID00658; -.
DR InterPro; IPR037445; MAGE.
DR InterPro; IPR021072; MAGE_N.
DR InterPro; IPR041898; MAGE_WH1.
DR InterPro; IPR041899; MAGE_WH2.
DR InterPro; IPR030093; MAGEA1.
DR InterPro; IPR002190; MHD_dom.
DR PANTHER; PTHR11736; PTHR11736; 1.
DR PANTHER; PTHR11736:SF49; PTHR11736:SF49; 1.
DR Pfam; PF01454; MAGE; 1.
DR Pfam; PF12440; MAGE_N; 1.
DR SMART; SM01373; MAGE; 1.
DR SMART; SM01392; MAGE_N; 1.
DR PROSITE; PS50838; MAGE; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome;
KW Transcription; Transcription regulation; Tumor antigen.
FT CHAIN 1..309
FT /note="Melanoma-associated antigen 1"
FT /id="PRO_0000156701"
FT DOMAIN 102..301
FT /note="MAGE"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00127"
FT REGION 45..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 49..64
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 57
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:20068231"
FT VARIANT 32
FT /note="T -> A (in dbSNP:rs2008160)"
FT /evidence="ECO:0000269|PubMed:15059299,
FT ECO:0000269|PubMed:15489334, ECO:0000269|Ref.4"
FT /id="VAR_004283"
FT VARIANT 63
FT /note="A -> T (in dbSNP:rs2233044)"
FT /id="VAR_053491"
FT VARIANT 72
FT /note="R -> Q (in dbSNP:rs2008144)"
FT /id="VAR_011737"
FT VARIANT 278
FT /note="K -> T (in a breast cancer sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_036581"
FT MUTAGEN 163
FT /note="D->A: Abolishes HLA-A1 binding."
FT /evidence="ECO:0000269|PubMed:8113684"
FT MUTAGEN 169
FT /note="Y->A: Abolishes HLA-A1 binding."
FT /evidence="ECO:0000269|PubMed:8113684"
SQ SEQUENCE 309 AA; 34342 MW; 544EEB1F9F4E9D33 CRC64;
MSLEQRSLHC KPEEALEAQQ EALGLVCVQA ATSSSSPLVL GTLEEVPTAG STDPPQSPQG
ASAFPTTINF TRQRQPSEGS SSREEEGPST SCILESLFRA VITKKVADLV GFLLLKYRAR
EPVTKAEMLE SVIKNYKHCF PEIFGKASES LQLVFGIDVK EADPTGHSYV LVTCLGLSYD
GLLGDNQIMP KTGFLIIVLV MIAMEGGHAP EEEIWEELSV MEVYDGREHS AYGEPRKLLT
QDLVQEKYLE YRQVPDSDPA RYEFLWGPRA LAETSYVKVL EYVIKVSARV RFFFPSLREA
ALREEEEGV
