MAGA4_HUMAN
ID MAGA4_HUMAN Reviewed; 317 AA.
AC P43358; Q14798;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 08-FEB-2011, sequence version 2.
DT 03-AUG-2022, entry version 177.
DE RecName: Full=Melanoma-associated antigen 4;
DE AltName: Full=Cancer/testis antigen 1.4;
DE Short=CT1.4;
DE AltName: Full=MAGE-4 antigen;
DE AltName: Full=MAGE-41 antigen;
DE AltName: Full=MAGE-X2 antigen;
GN Name=MAGEA4; Synonyms=MAGE4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT THR-173.
RC TISSUE=Blood;
RX PubMed=7927540; DOI=10.1007/bf01246677;
RA De Plaen E., Arden K., Traversari C., Gaforio J.J., Szikora J.-P.,
RA De Smet C., Brasseur F., van der Bruggen P., Lethe B.G., Lurquin C.,
RA Brasseur R., Chomez P., de Backer O., Cavenee W., Boon T.;
RT "Structure, chromosomal localization, and expression of 12 genes of the
RT MAGE family.";
RL Immunogenetics 40:360-369(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT THR-173.
RC TISSUE=Skin;
RX PubMed=8037761; DOI=10.1006/bbrc.1994.1963;
RA Ding M., Beck R.J., Keller C.J., Fenton R.G.;
RT "Cloning and analysis of MAGE-1-related genes.";
RL Biochem. Biophys. Res. Commun. 202:549-555(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT THR-173.
RX PubMed=7642112; DOI=10.1016/0378-1119(94)00680-q;
RA Imai Y., Shichijo S., Yamada A., Katayama T., Yano H., Itoh K.;
RT "Sequence analysis of the MAGE gene family encoding human tumor-rejection
RT antigens.";
RL Gene 160:287-290(1995).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT THR-173.
RC TISSUE=Duodenum;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [7]
RP FUNCTION.
RX PubMed=22842486; DOI=10.3892/or.2012.1934;
RA Bhan S., Chuang A., Negi S.S., Glazer C.A., Califano J.A.;
RT "MAGEA4 induces growth in normal oral keratinocytes by inhibiting growth
RT arrest and apoptosis.";
RL Oncol. Rep. 28:1498-1502(2012).
RN [8]
RP X-RAY CRYSTALLOGRAPHY (1.4 ANGSTROMS) OF 230-239.
RX PubMed=11502003; DOI=10.1006/jmbi.2001.4816;
RA Hillig R.C., Coulie P.G., Stroobant V., Saenger W., Ziegler A.,
RA Hulsmeyer M.;
RT "High-resolution structure of HLA-A*0201 in complex with a tumour-specific
RT antigenic peptide encoded by the MAGE-A4 gene.";
RL J. Mol. Biol. 310:1167-1176(2001).
RN [9]
RP VARIANT [LARGE SCALE ANALYSIS] ASP-153.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
RN [10]
RP VARIANT GLN-137.
RX PubMed=23092983; DOI=10.1038/tp.2012.102;
RA Nava C., Lamari F., Heron D., Mignot C., Rastetter A., Keren B., Cohen D.,
RA Faudet A., Bouteiller D., Gilleron M., Jacquette A., Whalen S., Afenjar A.,
RA Perisse D., Laurent C., Dupuits C., Gautier C., Gerard M., Huguet G.,
RA Caillet S., Leheup B., Leboyer M., Gillberg C., Delorme R., Bourgeron T.,
RA Brice A., Depienne C.;
RT "Analysis of the chromosome X exome in patients with autism spectrum
RT disorders identified novel candidate genes, including TMLHE.";
RL Transl. Psychiatry 2:E179-E179(2012).
RN [11]
RP VARIANT GLU-230.
RX PubMed=28229514; DOI=10.1002/humu.23200;
RA Imagawa E., Higashimoto K., Sakai Y., Numakura C., Okamoto N.,
RA Matsunaga S., Ryo A., Sato Y., Sanefuji M., Ihara K., Takada Y.,
RA Nishimura G., Saitsu H., Mizuguchi T., Miyatake S., Nakashima M.,
RA Miyake N., Soejima H., Matsumoto N.;
RT "Mutations in genes encoding polycomb repressive complex 2 subunits cause
RT Weaver syndrome.";
RL Hum. Mutat. 38:637-648(2017).
CC -!- FUNCTION: Regulates cell proliferation through the inhibition of cell
CC cycle arrest at the G1 phase (PubMed:22842486). Also negatively
CC regulates p53-mediated apoptosis (PubMed:22842486).
CC {ECO:0000269|PubMed:22842486}.
CC -!- INTERACTION:
CC P43358; A2BDD9: AMOT; NbExp=5; IntAct=EBI-743122, EBI-17286414;
CC P43358; P10176: COX8A; NbExp=3; IntAct=EBI-743122, EBI-3904738;
CC P43358; Q8N4P3-2: HDDC3; NbExp=3; IntAct=EBI-743122, EBI-12037393;
CC P43358; Q5SW96: LDLRAP1; NbExp=3; IntAct=EBI-743122, EBI-747813;
CC P43358; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-743122, EBI-79165;
CC P43358; Q9NUX5: POT1; NbExp=2; IntAct=EBI-743122, EBI-752420;
CC P43358; O75832: PSMD10; NbExp=5; IntAct=EBI-743122, EBI-752185;
CC P43358; Q08623: PUDP; NbExp=3; IntAct=EBI-743122, EBI-12807240;
CC P43358; Q9NS91: RAD18; NbExp=4; IntAct=EBI-743122, EBI-2339393;
CC P43358; Q8WW24: TEKT4; NbExp=7; IntAct=EBI-743122, EBI-750487;
CC P43358; Q86WT6: TRIM69; NbExp=3; IntAct=EBI-743122, EBI-749955;
CC P43358; Q86WT6-2: TRIM69; NbExp=3; IntAct=EBI-743122, EBI-11525489;
CC P43358; Q6FI91: TSPYL; NbExp=3; IntAct=EBI-743122, EBI-723389;
CC P43358; Q9UJ04: TSPYL4; NbExp=6; IntAct=EBI-743122, EBI-308511;
CC P43358; Q99757: TXN2; NbExp=3; IntAct=EBI-743122, EBI-2932492;
CC P43358; Q9BZV1: UBXN6; NbExp=4; IntAct=EBI-743122, EBI-1993899;
CC P43358; P14927: UQCRB; NbExp=5; IntAct=EBI-743122, EBI-743128;
CC P43358; Q2YD98: UVSSA; NbExp=3; IntAct=EBI-743122, EBI-11153331;
CC P43358; Q13105: ZBTB17; NbExp=5; IntAct=EBI-743122, EBI-372156;
CC P43358; Q9H609: ZNF576; NbExp=5; IntAct=EBI-743122, EBI-3921014;
CC -!- TISSUE SPECIFICITY: Expressed in many tumors of several types, such as
CC melanoma, head and neck squamous cell carcinoma, lung carcinoma and
CC breast carcinoma, but not in normal tissues except for testes and
CC placenta.
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DR EMBL; U10687; AAA68871.1; -; Genomic_DNA.
DR EMBL; U10688; AAA68872.1; -; Genomic_DNA.
DR EMBL; U10340; AAA19007.1; -; mRNA.
DR EMBL; D32075; BAA06841.1; -; mRNA.
DR EMBL; D32077; BAA06843.1; -; mRNA.
DR EMBL; AF274855; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC017723; AAH17723.1; -; mRNA.
DR CCDS; CCDS14702.1; -.
DR PIR; I38661; I38661.
DR RefSeq; NP_001011548.1; NM_001011548.1.
DR RefSeq; NP_001011549.1; NM_001011549.1.
DR RefSeq; NP_001011550.1; NM_001011550.1.
DR RefSeq; NP_002353.3; NM_002362.4.
DR RefSeq; XP_005274735.1; XM_005274678.3.
DR RefSeq; XP_005274736.1; XM_005274679.3.
DR PDB; 1I4F; X-ray; 1.40 A; C=230-239.
DR PDB; 2WA0; X-ray; 2.30 A; A=101-317.
DR PDB; 6TRN; X-ray; 1.35 A; C=230-239.
DR PDB; 6TRO; X-ray; 3.00 A; C=230-239.
DR PDBsum; 1I4F; -.
DR PDBsum; 2WA0; -.
DR PDBsum; 6TRN; -.
DR PDBsum; 6TRO; -.
DR AlphaFoldDB; P43358; -.
DR SMR; P43358; -.
DR BioGRID; 110277; 52.
DR IntAct; P43358; 36.
DR MINT; P43358; -.
DR STRING; 9606.ENSP00000353379; -.
DR ChEMBL; CHEMBL4296022; -.
DR iPTMnet; P43358; -.
DR PhosphoSitePlus; P43358; -.
DR BioMuta; MAGEA4; -.
DR DMDM; 322510046; -.
DR EPD; P43358; -.
DR jPOST; P43358; -.
DR MassIVE; P43358; -.
DR MaxQB; P43358; -.
DR PaxDb; P43358; -.
DR PeptideAtlas; P43358; -.
DR PRIDE; P43358; -.
DR ProteomicsDB; 55620; -.
DR Antibodypedia; 17051; 392 antibodies from 33 providers.
DR CPTC; P43358; 3 antibodies.
DR DNASU; 4103; -.
DR Ensembl; ENST00000276344.6; ENSP00000276344.2; ENSG00000147381.12.
DR Ensembl; ENST00000360243.6; ENSP00000353379.2; ENSG00000147381.12.
DR Ensembl; ENST00000370335.5; ENSP00000359360.1; ENSG00000147381.12.
DR Ensembl; ENST00000370340.7; ENSP00000359365.3; ENSG00000147381.12.
DR Ensembl; ENST00000393920.6; ENSP00000377497.1; ENSG00000147381.12.
DR Ensembl; ENST00000393921.6; ENSP00000377498.1; ENSG00000147381.12.
DR Ensembl; ENST00000430273.6; ENSP00000394149.2; ENSG00000147381.12.
DR Ensembl; ENST00000457310.6; ENSP00000402186.2; ENSG00000147381.12.
DR Ensembl; ENST00000682265.1; ENSP00000506838.1; ENSG00000147381.12.
DR Ensembl; ENST00000684668.1; ENSP00000507023.1; ENSG00000147381.12.
DR GeneID; 4103; -.
DR KEGG; hsa:4103; -.
DR MANE-Select; ENST00000276344.6; ENSP00000276344.2; NM_001011548.1; NP_001011548.1.
DR UCSC; uc004ffa.3; human.
DR CTD; 4103; -.
DR DisGeNET; 4103; -.
DR GeneCards; MAGEA4; -.
DR HGNC; HGNC:6802; MAGEA4.
DR HPA; ENSG00000147381; Tissue enriched (testis).
DR MIM; 300175; gene.
DR neXtProt; NX_P43358; -.
DR OpenTargets; ENSG00000147381; -.
DR PharmGKB; PA30548; -.
DR VEuPathDB; HostDB:ENSG00000147381; -.
DR eggNOG; KOG4562; Eukaryota.
DR GeneTree; ENSGT00940000166837; -.
DR HOGENOM; CLU_039582_1_2_1; -.
DR InParanoid; P43358; -.
DR OMA; VNFTCWR; -.
DR OrthoDB; 1195799at2759; -.
DR PhylomeDB; P43358; -.
DR TreeFam; TF328505; -.
DR PathwayCommons; P43358; -.
DR SignaLink; P43358; -.
DR BioGRID-ORCS; 4103; 10 hits in 687 CRISPR screens.
DR ChiTaRS; MAGEA4; human.
DR EvolutionaryTrace; P43358; -.
DR GeneWiki; MAGEA4; -.
DR GenomeRNAi; 4103; -.
DR Pharos; P43358; Tbio.
DR PRO; PR:P43358; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; P43358; protein.
DR Bgee; ENSG00000147381; Expressed in right testis and 52 other tissues.
DR ExpressionAtlas; P43358; baseline and differential.
DR Genevisible; P43358; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0042826; F:histone deacetylase binding; IBA:GO_Central.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0045787; P:positive regulation of cell cycle; IMP:UniProtKB.
DR Gene3D; 1.10.10.1200; -; 1.
DR Gene3D; 1.10.10.1210; -; 1.
DR InterPro; IPR037445; MAGE.
DR InterPro; IPR021072; MAGE_N.
DR InterPro; IPR041898; MAGE_WH1.
DR InterPro; IPR041899; MAGE_WH2.
DR InterPro; IPR030098; MAGEA4/MAGEA5P.
DR InterPro; IPR002190; MHD_dom.
DR PANTHER; PTHR11736; PTHR11736; 1.
DR PANTHER; PTHR11736:SF48; PTHR11736:SF48; 1.
DR Pfam; PF01454; MAGE; 1.
DR Pfam; PF12440; MAGE_N; 1.
DR SMART; SM01373; MAGE; 1.
DR SMART; SM01392; MAGE_N; 1.
DR PROSITE; PS50838; MAGE; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Reference proteome; Tumor antigen.
FT CHAIN 1..317
FT /note="Melanoma-associated antigen 4"
FT /id="PRO_0000156704"
FT DOMAIN 110..309
FT /note="MAGE"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00127"
FT REGION 1..102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 34..48
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 63..98
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 137
FT /note="L -> Q (in dbSNP:rs1224431639)"
FT /evidence="ECO:0000269|PubMed:23092983"
FT /id="VAR_076262"
FT VARIANT 153
FT /note="G -> D (in a breast cancer sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_036582"
FT VARIANT 173
FT /note="A -> T (in dbSNP:rs1047251)"
FT /evidence="ECO:0000269|PubMed:15489334,
FT ECO:0000269|PubMed:7642112, ECO:0000269|PubMed:7927540,
FT ECO:0000269|PubMed:8037761"
FT /id="VAR_004284"
FT VARIANT 230
FT /note="G -> E (in dbSNP:rs773875619)"
FT /evidence="ECO:0000269|PubMed:28229514"
FT /id="VAR_078319"
FT CONFLICT 3
FT /note="S -> L (in Ref. 3; BAA06841)"
FT /evidence="ECO:0000305"
FT CONFLICT 48
FT /note="P -> L (in Ref. 3; BAA06841)"
FT /evidence="ECO:0000305"
FT CONFLICT 53
FT /note="E -> K (in Ref. 3; BAA06841)"
FT /evidence="ECO:0000305"
FT CONFLICT 61
FT /note="G -> D (in Ref. 3; BAA06841)"
FT /evidence="ECO:0000305"
FT CONFLICT 95..96
FT /note="GP -> EA (in Ref. 3; BAA06841)"
FT /evidence="ECO:0000305"
FT CONFLICT 307
FT /note="E -> Q (in Ref. 2; AAA19007)"
FT /evidence="ECO:0000305"
FT HELIX 102..126
FT /evidence="ECO:0007829|PDB:2WA0"
FT HELIX 133..139
FT /evidence="ECO:0007829|PDB:2WA0"
FT HELIX 145..147
FT /evidence="ECO:0007829|PDB:2WA0"
FT HELIX 148..163
FT /evidence="ECO:0007829|PDB:2WA0"
FT STRAND 165..169
FT /evidence="ECO:0007829|PDB:2WA0"
FT STRAND 176..181
FT /evidence="ECO:0007829|PDB:2WA0"
FT HELIX 182..184
FT /evidence="ECO:0007829|PDB:2WA0"
FT HELIX 200..213
FT /evidence="ECO:0007829|PDB:2WA0"
FT HELIX 219..228
FT /evidence="ECO:0007829|PDB:2WA0"
FT TURN 238..240
FT /evidence="ECO:0007829|PDB:2WA0"
FT HELIX 243..248
FT /evidence="ECO:0007829|PDB:2WA0"
FT HELIX 250..253
FT /evidence="ECO:0007829|PDB:2WA0"
FT STRAND 256..260
FT /evidence="ECO:0007829|PDB:2WA0"
FT STRAND 271..274
FT /evidence="ECO:0007829|PDB:2WA0"
FT HELIX 276..281
FT /evidence="ECO:0007829|PDB:2WA0"
FT HELIX 284..295
FT /evidence="ECO:0007829|PDB:2WA0"
FT HELIX 305..309
FT /evidence="ECO:0007829|PDB:2WA0"
SQ SEQUENCE 317 AA; 34899 MW; C6AA2EE306963E7D CRC64;
MSSEQKSQHC KPEEGVEAQE EALGLVGAQA PTTEEQEAAV SSSSPLVPGT LEEVPAAESA
GPPQSPQGAS ALPTTISFTC WRQPNEGSSS QEEEGPSTSP DAESLFREAL SNKVDELAHF
LLRKYRAKEL VTKAEMLERV IKNYKRCFPV IFGKASESLK MIFGIDVKEV DPASNTYTLV
TCLGLSYDGL LGNNQIFPKT GLLIIVLGTI AMEGDSASEE EIWEELGVMG VYDGREHTVY
GEPRKLLTQD WVQENYLEYR QVPGSNPARY EFLWGPRALA ETSYVKVLEH VVRVNARVRI
AYPSLREAAL LEEEEGV
