MAGA5_HUMAN
ID MAGA5_HUMAN Reviewed; 124 AA.
AC P43359; Q32MD0;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Putative melanoma-associated antigen 5P {ECO:0000305};
DE AltName: Full=Cancer/testis antigen 1.5;
DE Short=CT1.5;
DE AltName: Full=MAGE family member A5 pseudogene {ECO:0000312|HGNC:HGNC:6803};
DE AltName: Full=MAGE-5 antigen;
GN Name=MAGEA5P {ECO:0000312|HGNC:HGNC:6803};
GN Synonyms=MAGE5 {ECO:0000312|HGNC:HGNC:6803},
GN MAGEA5 {ECO:0000312|HGNC:HGNC:6803};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=7927540; DOI=10.1007/bf01246677;
RA De Plaen E., Arden K., Traversari C., Gaforio J.J., Szikora J.-P.,
RA De Smet C., Brasseur F., van der Bruggen P., Lethe B.G., Lurquin C.,
RA Brasseur R., Chomez P., de Backer O., Cavenee W., Boon T.;
RT "Structure, chromosomal localization, and expression of 12 genes of the
RT MAGE family.";
RL Immunogenetics 40:360-369(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP FUNCTION.
RX PubMed=17942928; DOI=10.1158/0008-5472.can-07-1478;
RA Yang B., O'Herrin S.M., Wu J., Reagan-Shaw S., Ma Y., Bhat K.M.,
RA Gravekamp C., Setaluri V., Peters N., Hoffmann F.M., Peng H., Ivanov A.V.,
RA Simpson A.J., Longley B.J.;
RT "MAGE-A, mMage-b, and MAGE-C proteins form complexes with KAP1 and suppress
RT p53-dependent apoptosis in MAGE-positive cell lines.";
RL Cancer Res. 67:9954-9962(2007).
CC -!- FUNCTION: May negatively regulates apoptosis.
CC {ECO:0000269|PubMed:17942928}.
CC -!- TISSUE SPECIFICITY: Expressed in many tumors of several types, such as
CC melanoma, head and neck squamous cell carcinoma, lung carcinoma and
CC breast carcinoma, but not in normal tissues except for testes.
CC -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR EMBL; U10690; AAA68874.1; -; Genomic_DNA.
DR EMBL; U10689; AAA68873.1; -; Genomic_DNA.
DR EMBL; BC109187; AAI09188.1; -; mRNA.
DR PIR; I38663; I38663.
DR RefSeq; NP_001191740.1; NM_001204811.2.
DR RefSeq; NP_066387.1; NM_021049.4.
DR AlphaFoldDB; P43359; -.
DR SMR; P43359; -.
DR iPTMnet; P43359; -.
DR PhosphoSitePlus; P43359; -.
DR BioMuta; HGNC:6803; -.
DR DMDM; 1170859; -.
DR MassIVE; P43359; -.
DR PeptideAtlas; P43359; -.
DR PRIDE; P43359; -.
DR DNASU; 100533997; -.
DR DNASU; 4104; -.
DR GeneID; 100533997; -.
DR GeneID; 4104; -.
DR KEGG; hsa:100533997; -.
DR CTD; 4104; -.
DR DisGeNET; 4104; -.
DR GeneCards; MAGEA5P; -.
DR HGNC; HGNC:6803; MAGEA5P.
DR MIM; 300340; gene.
DR neXtProt; NX_P43359; -.
DR OrthoDB; 1590044at2759; -.
DR PhylomeDB; P43359; -.
DR PathwayCommons; P43359; -.
DR BioGRID-ORCS; 100533997; 8 hits in 142 CRISPR screens.
DR BioGRID-ORCS; 4104; 1 hit in 120 CRISPR screens.
DR Pharos; P43359; Tdark.
DR PRO; PR:P43359; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; P43359; protein.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0042826; F:histone deacetylase binding; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0051983; P:regulation of chromosome segregation; IMP:HGNC.
DR InterPro; IPR037445; MAGE.
DR InterPro; IPR021072; MAGE_N.
DR InterPro; IPR030098; MAGEA4/MAGEA5P.
DR PANTHER; PTHR11736; PTHR11736; 1.
DR PANTHER; PTHR11736:SF48; PTHR11736:SF48; 1.
DR Pfam; PF12440; MAGE_N; 1.
DR SMART; SM01392; MAGE_N; 1.
PE 5: Uncertain;
KW Reference proteome; Tumor antigen.
FT CHAIN 1..124
FT /note="Putative melanoma-associated antigen 5P"
FT /id="PRO_0000156705"
FT DOMAIN 3..124
FT /note="MAGE"
FT REGION 1..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 82..103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..47
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 82..97
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 29
FT /note="Q -> H (in dbSNP:rs188387)"
FT /id="VAR_053492"
SQ SEQUENCE 124 AA; 13016 MW; 3D8457AFBFD7531E CRC64;
MSLEQKSQHC KPEEGLDTQE EALGLVGVQA ATTEEQEAVS SSSPLVPGTL GEVPAAGSPG
PLKSPQGASA IPTAIDFTLW RQSIKGSSNQ EEEGPSTSPD PESVFRAALS KKVADLIHFL
LLKY
