MAGA8_HUMAN
ID MAGA8_HUMAN Reviewed; 318 AA.
AC P43361; Q9BUN9;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 16-DEC-2008, sequence version 2.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Melanoma-associated antigen 8;
DE AltName: Full=Cancer/testis antigen 1.8;
DE Short=CT1.8;
DE AltName: Full=MAGE-8 antigen;
GN Name=MAGEA8; Synonyms=MAGE8;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA Phelan M., Farmer A.;
RT "Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-232.
RX PubMed=7927540; DOI=10.1007/bf01246677;
RA De Plaen E., Arden K., Traversari C., Gaforio J.J., Szikora J.-P.,
RA De Smet C., Brasseur F., van der Bruggen P., Lethe B.G., Lurquin C.,
RA Brasseur R., Chomez P., de Backer O., Cavenee W., Boon T.;
RT "Structure, chromosomal localization, and expression of 12 genes of the
RT MAGE family.";
RL Immunogenetics 40:360-369(1994).
CC -!- FUNCTION: Not known, though may play a role in embryonal development
CC and tumor transformation or aspects of tumor progression.
CC -!- INTERACTION:
CC P43361; Q5H9J7: BEX5; NbExp=7; IntAct=EBI-10182930, EBI-10243741;
CC P43361; Q9P031: CCDC59; NbExp=3; IntAct=EBI-10182930, EBI-1047110;
CC P43361; P28676: GCA; NbExp=9; IntAct=EBI-10182930, EBI-947242;
CC P43361; P13473-2: LAMP2; NbExp=3; IntAct=EBI-10182930, EBI-21591415;
CC P43361; P25791: LMO2; NbExp=3; IntAct=EBI-10182930, EBI-739696;
CC P43361; Q9BS40: LXN; NbExp=3; IntAct=EBI-10182930, EBI-1044504;
CC P43361; O15481: MAGEB4; NbExp=3; IntAct=EBI-10182930, EBI-751857;
CC P43361; P40692: MLH1; NbExp=7; IntAct=EBI-10182930, EBI-744248;
CC P43361; Q5JR59: MTUS2; NbExp=3; IntAct=EBI-10182930, EBI-742948;
CC P43361; Q13563: PKD2; NbExp=4; IntAct=EBI-10182930, EBI-7813714;
CC P43361; Q9Y371: SH3GLB1; NbExp=3; IntAct=EBI-10182930, EBI-2623095;
CC P43361; Q93009: USP7; NbExp=2; IntAct=EBI-10182930, EBI-302474;
CC P43361; Q9UK13: ZNF221; NbExp=3; IntAct=EBI-10182930, EBI-14513896;
CC P43361; Q9NZL3: ZNF224; NbExp=3; IntAct=EBI-10182930, EBI-12357267;
CC P43361; Q8TAU3: ZNF417; NbExp=3; IntAct=EBI-10182930, EBI-740727;
CC -!- TISSUE SPECIFICITY: Expressed in many tumors of several types, such as
CC melanoma, head and neck squamous cell carcinoma, lung carcinoma and
CC breast carcinoma, but not in normal tissues except for testis and
CC placenta.
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DR EMBL; BT007340; AAP36004.1; -; mRNA.
DR EMBL; AC016941; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471169; EAW99373.1; -; Genomic_DNA.
DR EMBL; BC002455; AAH02455.1; -; mRNA.
DR EMBL; BC012744; AAH12744.1; -; mRNA.
DR EMBL; U10693; AAA68876.1; ALT_TERM; Genomic_DNA.
DR CCDS; CCDS14692.1; -.
DR PIR; I38667; I38667.
DR RefSeq; NP_001159872.1; NM_001166400.1.
DR RefSeq; NP_001159873.1; NM_001166401.1.
DR RefSeq; NP_005355.2; NM_005364.4.
DR RefSeq; XP_016885009.1; XM_017029520.1.
DR AlphaFoldDB; P43361; -.
DR SMR; P43361; -.
DR BioGRID; 110281; 146.
DR IntAct; P43361; 18.
DR STRING; 9606.ENSP00000438293; -.
DR iPTMnet; P43361; -.
DR PhosphoSitePlus; P43361; -.
DR BioMuta; MAGEA8; -.
DR DMDM; 218511674; -.
DR jPOST; P43361; -.
DR MassIVE; P43361; -.
DR MaxQB; P43361; -.
DR PaxDb; P43361; -.
DR PeptideAtlas; P43361; -.
DR PRIDE; P43361; -.
DR ProteomicsDB; 55623; -.
DR Antibodypedia; 30635; 147 antibodies from 24 providers.
DR DNASU; 4107; -.
DR Ensembl; ENST00000286482.6; ENSP00000286482.1; ENSG00000156009.10.
DR Ensembl; ENST00000535454.5; ENSP00000438293.1; ENSG00000156009.10.
DR Ensembl; ENST00000542674.5; ENSP00000443776.1; ENSG00000156009.10.
DR GeneID; 4107; -.
DR KEGG; hsa:4107; -.
DR MANE-Select; ENST00000286482.6; ENSP00000286482.1; NM_005364.5; NP_005355.2.
DR UCSC; uc004fdw.3; human.
DR CTD; 4107; -.
DR GeneCards; MAGEA8; -.
DR HGNC; HGNC:6806; MAGEA8.
DR HPA; ENSG00000156009; Tissue enriched (placenta).
DR MIM; 300341; gene.
DR neXtProt; NX_P43361; -.
DR OpenTargets; ENSG00000156009; -.
DR PharmGKB; PA30552; -.
DR VEuPathDB; HostDB:ENSG00000156009; -.
DR eggNOG; KOG4562; Eukaryota.
DR GeneTree; ENSGT00940000165348; -.
DR HOGENOM; CLU_039582_1_1_1; -.
DR InParanoid; P43361; -.
DR OMA; VMEGSCA; -.
DR OrthoDB; 1195799at2759; -.
DR PhylomeDB; P43361; -.
DR TreeFam; TF328505; -.
DR PathwayCommons; P43361; -.
DR SignaLink; P43361; -.
DR BioGRID-ORCS; 4107; 12 hits in 702 CRISPR screens.
DR ChiTaRS; MAGEA8; human.
DR GenomeRNAi; 4107; -.
DR Pharos; P43361; Tdark.
DR PRO; PR:P43361; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; P43361; protein.
DR Bgee; ENSG00000156009; Expressed in placenta and 63 other tissues.
DR Genevisible; P43361; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0042826; F:histone deacetylase binding; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.10.1200; -; 1.
DR Gene3D; 1.10.10.1210; -; 1.
DR InterPro; IPR037445; MAGE.
DR InterPro; IPR021072; MAGE_N.
DR InterPro; IPR041898; MAGE_WH1.
DR InterPro; IPR041899; MAGE_WH2.
DR InterPro; IPR030095; MAGEA8.
DR InterPro; IPR002190; MHD_dom.
DR PANTHER; PTHR11736; PTHR11736; 1.
DR PANTHER; PTHR11736:SF65; PTHR11736:SF65; 1.
DR Pfam; PF01454; MAGE; 1.
DR Pfam; PF12440; MAGE_N; 1.
DR SMART; SM01373; MAGE; 1.
DR SMART; SM01392; MAGE_N; 1.
DR PROSITE; PS50838; MAGE; 1.
PE 1: Evidence at protein level;
KW Reference proteome; Tumor antigen.
FT CHAIN 1..318
FT /note="Melanoma-associated antigen 8"
FT /id="PRO_0000156707"
FT DOMAIN 112..311
FT /note="MAGE"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00127"
FT REGION 1..103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 34..96
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 121
FT /note="R -> H (in dbSNP:rs35744768)"
FT /id="VAR_053494"
FT VARIANT 306
FT /note="S -> F (in dbSNP:rs12010332)"
FT /id="VAR_053495"
SQ SEQUENCE 318 AA; 35215 MW; EA02C1FB42F6C080 CRC64;
MLLGQKSQRY KAEEGLQAQG EAPGLMDVQI PTAEEQKAAS SSSTLIMGTL EEVTDSGSPS
PPQSPEGASS SLTVTDSTLW SQSDEGSSSN EEEGPSTSPD PAHLESLFRE ALDEKVAELV
RFLLRKYQIK EPVTKAEMLE SVIKNYKNHF PDIFSKASEC MQVIFGIDVK EVDPAGHSYI
LVTCLGLSYD GLLGDDQSTP KTGLLIIVLG MILMEGSRAP EEAIWEALSV MGLYDGREHS
VYWKLRKLLT QEWVQENYLE YRQAPGSDPV RYEFLWGPRA LAETSYVKVL EHVVRVNARV
RISYPSLHEE ALGEEKGV
