MAGA9_HUMAN
ID MAGA9_HUMAN Reviewed; 315 AA.
AC P43362; A8K8A7; Q7Z5K4; Q92910;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 163.
DE RecName: Full=Melanoma-associated antigen 9;
DE AltName: Full=Cancer/testis antigen 1.9;
DE Short=CT1.9;
DE AltName: Full=MAGE-9 antigen;
GN Name=MAGEA9; Synonyms=MAGE9, MAGEA9A;
GN and
GN Name=MAGEA9B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=7927540; DOI=10.1007/bf01246677;
RA De Plaen E., Arden K., Traversari C., Gaforio J.J., Szikora J.-P.,
RA De Smet C., Brasseur F., van der Bruggen P., Lethe B.G., Lurquin C.,
RA Brasseur R., Chomez P., de Backer O., Cavenee W., Boon T.;
RT "Structure, chromosomal localization, and expression of 12 genes of the
RT MAGE family.";
RL Immunogenetics 40:360-369(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9147653; DOI=10.1093/hmg/6.3.479;
RA Timms K.M., Bondeson M.-L., Ansari-Lari M.A., Lagerstedt K., Muzny D.M.,
RA Dugan-Rocha S.P., Nelson D.L., Pettersson U., Gibbs R.A.;
RT "Molecular and phenotypic variation in patients with severe Hunter
RT syndrome.";
RL Hum. Mol. Genet. 6:479-486(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Liver;
RA Zhu J., Feng Z., Guan X.;
RT "MAGE-9 antigen (MAGE9) gene expressed in human hepatocellular carcinoma
RT patients.";
RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Esophagus, and Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP VARIANT HIS-31.
RX PubMed=20598277; DOI=10.1016/j.ajhg.2010.06.008;
RA Sun Y., Almomani R., Aten E., Celli J., van der Heijden J., Venselaar H.,
RA Robertson S.P., Baroncini A., Franco B., Basel-Vanagaite L., Horii E.,
RA Drut R., Ariyurek Y., den Dunnen J.T., Breuning M.H.;
RT "Terminal osseous dysplasia is caused by a single recurrent mutation in the
RT FLNA gene.";
RL Am. J. Hum. Genet. 87:146-153(2010).
CC -!- FUNCTION: Not known, though may play a role in embryonal development
CC and tumor transformation or aspects of tumor progression.
CC -!- INTERACTION:
CC P43362; Q9UKG1: APPL1; NbExp=4; IntAct=EBI-10209139, EBI-741243;
CC -!- TISSUE SPECIFICITY: Expressed in many tumors of several types, such as
CC melanoma, head and neck squamous cell carcinoma, lung carcinoma and
CC breast carcinoma, but not in normal tissues except for testes and
CC placenta.
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DR EMBL; U10694; AAA68877.1; -; Genomic_DNA.
DR EMBL; U66083; AAB67888.1; -; Genomic_DNA.
DR EMBL; AY310325; AAP82171.1; -; mRNA.
DR EMBL; AK292272; BAF84961.1; -; mRNA.
DR EMBL; AK313321; BAG36126.1; -; mRNA.
DR EMBL; CH471169; EAW99372.1; -; Genomic_DNA.
DR EMBL; BC002351; AAH02351.1; -; mRNA.
DR CCDS; CCDS14691.1; -.
DR CCDS; CCDS35423.1; -.
DR PIR; I38668; I38668.
DR RefSeq; NP_001074259.1; NM_001080790.1.
DR RefSeq; NP_005356.1; NM_005365.4.
DR RefSeq; XP_005262391.1; XM_005262334.3.
DR RefSeq; XP_005262392.1; XM_005262335.3.
DR RefSeq; XP_005278249.1; XM_005278192.3.
DR RefSeq; XP_005278250.1; XM_005278193.3.
DR AlphaFoldDB; P43362; -.
DR SMR; P43362; -.
DR BioGRID; 110282; 218.
DR BioGRID; 608698; 7.
DR IntAct; P43362; 5.
DR STRING; 9606.ENSP00000243314; -.
DR iPTMnet; P43362; -.
DR PhosphoSitePlus; P43362; -.
DR BioMuta; MAGEA9B; -.
DR DMDM; 1170862; -.
DR MassIVE; P43362; -.
DR MaxQB; P43362; -.
DR PaxDb; P43362; -.
DR PeptideAtlas; P43362; -.
DR PRIDE; P43362; -.
DR ProteomicsDB; 55624; -.
DR Antibodypedia; 16920; 307 antibodies from 29 providers.
DR Antibodypedia; 72928; 2 antibodies from 1 providers.
DR DNASU; 4108; -.
DR Ensembl; ENST00000243314.5; ENSP00000243314.5; ENSG00000123584.7.
DR Ensembl; ENST00000595065.6; ENSP00000471017.1; ENSG00000267978.6.
DR GeneID; 4108; -.
DR GeneID; 728269; -.
DR KEGG; hsa:4108; -.
DR KEGG; hsa:728269; -.
DR MANE-Select; ENST00000243314.5; ENSP00000243314.5; NM_005365.5; NP_005356.1.
DR MANE-Select; ENST00000595065.6; ENSP00000471017.1; NM_001080790.1; NP_001074259.1.
DR UCSC; uc004fdk.4; human.
DR CTD; 4108; -.
DR CTD; 728269; -.
DR DisGeNET; 4108; -.
DR DisGeNET; 728269; -.
DR GeneCards; MAGEA9; -.
DR GeneCards; MAGEA9B; -.
DR HGNC; HGNC:6807; MAGEA9.
DR HGNC; HGNC:31909; MAGEA9B.
DR HPA; ENSG00000123584; Tissue enriched (testis).
DR HPA; ENSG00000267978; Tissue enriched (testis).
DR MIM; 300342; gene.
DR MIM; 300764; gene.
DR neXtProt; NX_P43362; -.
DR OpenTargets; ENSG00000123584; -.
DR OpenTargets; ENSG00000267978; -.
DR PharmGKB; PA145148473; -.
DR VEuPathDB; HostDB:ENSG00000123584; -.
DR VEuPathDB; HostDB:ENSG00000267978; -.
DR eggNOG; KOG4562; Eukaryota.
DR GeneTree; ENSGT00940000165994; -.
DR HOGENOM; CLU_039582_1_2_1; -.
DR InParanoid; P43362; -.
DR OMA; KHYFPVI; -.
DR OrthoDB; 1195799at2759; -.
DR PhylomeDB; P43362; -.
DR TreeFam; TF328505; -.
DR PathwayCommons; P43362; -.
DR SignaLink; P43362; -.
DR BioGRID-ORCS; 4108; 12 hits in 581 CRISPR screens.
DR BioGRID-ORCS; 728269; 20 hits in 592 CRISPR screens.
DR ChiTaRS; MAGEA9B; human.
DR GeneWiki; MAGEA9; -.
DR Pharos; P43362; Tbio.
DR PRO; PR:P43362; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; P43362; protein.
DR Bgee; ENSG00000123584; Expressed in right testis and 16 other tissues.
DR ExpressionAtlas; P43362; baseline and differential.
DR Genevisible; P43362; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0042826; F:histone deacetylase binding; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.10.1200; -; 1.
DR Gene3D; 1.10.10.1210; -; 1.
DR InterPro; IPR037445; MAGE.
DR InterPro; IPR021072; MAGE_N.
DR InterPro; IPR041898; MAGE_WH1.
DR InterPro; IPR041899; MAGE_WH2.
DR InterPro; IPR030096; MAGEA9.
DR InterPro; IPR002190; MHD_dom.
DR PANTHER; PTHR11736; PTHR11736; 1.
DR PANTHER; PTHR11736:SF62; PTHR11736:SF62; 1.
DR Pfam; PF12440; MAGE_N; 1.
DR SMART; SM01373; MAGE; 1.
DR SMART; SM01392; MAGE_N; 1.
DR PROSITE; PS50838; MAGE; 1.
PE 1: Evidence at protein level;
KW Reference proteome; Tumor antigen.
FT CHAIN 1..315
FT /note="Melanoma-associated antigen 9"
FT /id="PRO_0000156708"
FT DOMAIN 108..307
FT /note="MAGE"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00127"
FT REGION 1..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 45..67
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 31
FT /note="P -> H (in dbSNP:rs202146513)"
FT /evidence="ECO:0000269|PubMed:20598277"
FT /id="VAR_064160"
FT CONFLICT 89
FT /note="E -> G (in Ref. 3; AAP82171)"
FT /evidence="ECO:0000305"
FT CONFLICT 309
FT /note="G -> R (in Ref. 3; AAP82171)"
FT /evidence="ECO:0000305"
FT CONFLICT 312
FT /note="Q -> E (in Ref. 3; AAP82171)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 315 AA; 35088 MW; 7FD2ED10D680D928 CRC64;
MSLEQRSPHC KPDEDLEAQG EDLGLMGAQE PTGEEEETTS SSDSKEEEVS AAGSSSPPQS
PQGGASSSIS VYYTLWSQFD EGSSSQEEEE PSSSVDPAQL EFMFQEALKL KVAELVHFLL
HKYRVKEPVT KAEMLESVIK NYKRYFPVIF GKASEFMQVI FGTDVKEVDP AGHSYILVTA
LGLSCDSMLG DGHSMPKAAL LIIVLGVILT KDNCAPEEVI WEALSVMGVY VGKEHMFYGE
PRKLLTQDWV QENYLEYRQV PGSDPAHYEF LWGSKAHAET SYEKVINYLV MLNAREPICY
PSLYEEVLGE EQEGV
