MAGAA_HUMAN
ID MAGAA_HUMAN Reviewed; 369 AA.
AC P43363;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 11-JAN-2011, sequence version 2.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Melanoma-associated antigen 10;
DE AltName: Full=Cancer/testis antigen 1.10;
DE Short=CT1.10;
DE AltName: Full=MAGE-10 antigen;
GN Name=MAGEA10; Synonyms=MAGE10;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS LYS-166 AND ILE-234.
RX PubMed=7927540; DOI=10.1007/bf01246677;
RA De Plaen E., Arden K., Traversari C., Gaforio J.J., Szikora J.-P.,
RA De Smet C., Brasseur F., van der Bruggen P., Lethe B.G., Lurquin C.,
RA Brasseur R., Chomez P., de Backer O., Cavenee W., Boon T.;
RT "Structure, chromosomal localization, and expression of 12 genes of the
RT MAGE family.";
RL Immunogenetics 40:360-369(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS LYS-166 AND ILE-234.
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=21710496; DOI=10.1002/ijc.25777;
RA Schultz-Thater E., Piscuoglio S., Iezzi G., Le Magnen C., Zajac P.,
RA Carafa V., Terracciano L., Tornillo L., Spagnoli G.C.;
RT "MAGE-A10 is a nuclear protein frequently expressed in high percentages of
RT tumor cells in lung, skin and urothelial malignancies.";
RL Int. J. Cancer 129:1137-1148(2011).
CC -!- FUNCTION: Not known, though may play a role in embryonal development
CC and tumor transformation or aspects of tumor progression.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21710496}.
CC -!- TISSUE SPECIFICITY: Expressed in many tumors of several types, such as
CC melanoma, head and neck squamous cell carcinoma, lung carcinoma and
CC breast carcinoma, but not in normal tissues except for spermatogonia,
CC spermatocytes and placenta. {ECO:0000269|PubMed:21710496}.
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DR EMBL; U10685; AAA68869.1; -; Genomic_DNA.
DR EMBL; AC116666; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC004105; AAH04105.1; -; mRNA.
DR CCDS; CCDS14705.1; -.
DR PIR; I38659; I38659.
DR RefSeq; NP_001011543.2; NM_001011543.2.
DR RefSeq; NP_001238757.1; NM_001251828.1.
DR RefSeq; NP_066386.2; NM_021048.4.
DR AlphaFoldDB; P43363; -.
DR SMR; P43363; -.
DR BioGRID; 110283; 104.
DR IntAct; P43363; 41.
DR MINT; P43363; -.
DR STRING; 9606.ENSP00000244096; -.
DR GlyGen; P43363; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; P43363; -.
DR PhosphoSitePlus; P43363; -.
DR BioMuta; MAGEA10; -.
DR DMDM; 317373386; -.
DR jPOST; P43363; -.
DR MassIVE; P43363; -.
DR MaxQB; P43363; -.
DR PaxDb; P43363; -.
DR PeptideAtlas; P43363; -.
DR PRIDE; P43363; -.
DR ProteomicsDB; 55625; -.
DR TopDownProteomics; P43363; -.
DR Antibodypedia; 30725; 216 antibodies from 26 providers.
DR DNASU; 4109; -.
DR Ensembl; ENST00000244096.7; ENSP00000244096.3; ENSG00000124260.12.
DR Ensembl; ENST00000370323.9; ENSP00000359347.4; ENSG00000124260.12.
DR GeneID; 4109; -.
DR KEGG; hsa:4109; -.
DR MANE-Select; ENST00000370323.9; ENSP00000359347.4; NM_021048.5; NP_066386.3.
DR UCSC; uc004ffk.4; human.
DR CTD; 4109; -.
DR DisGeNET; 4109; -.
DR GeneCards; MAGEA10; -.
DR HGNC; HGNC:6797; MAGEA10.
DR HPA; ENSG00000124260; Group enriched (placenta, testis).
DR MIM; 300343; gene.
DR neXtProt; NX_P43363; -.
DR OpenTargets; ENSG00000124260; -.
DR PharmGKB; PA30543; -.
DR VEuPathDB; HostDB:ENSG00000124260; -.
DR eggNOG; KOG4562; Eukaryota.
DR GeneTree; ENSGT00940000154972; -.
DR HOGENOM; CLU_039582_1_1_1; -.
DR InParanoid; P43363; -.
DR OMA; DGMEHFI; -.
DR OrthoDB; 1195799at2759; -.
DR PhylomeDB; P43363; -.
DR TreeFam; TF328505; -.
DR PathwayCommons; P43363; -.
DR SignaLink; P43363; -.
DR BioGRID-ORCS; 4109; 7 hits in 687 CRISPR screens.
DR ChiTaRS; MAGEA10; human.
DR GenomeRNAi; 4109; -.
DR Pharos; P43363; Tbio.
DR PRO; PR:P43363; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; P43363; protein.
DR Bgee; ENSG00000124260; Expressed in placenta and 9 other tissues.
DR ExpressionAtlas; P43363; baseline and differential.
DR Genevisible; P43363; HS.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0042826; F:histone deacetylase binding; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.10.1200; -; 1.
DR Gene3D; 1.10.10.1210; -; 1.
DR InterPro; IPR037445; MAGE.
DR InterPro; IPR021072; MAGE_N.
DR InterPro; IPR041898; MAGE_WH1.
DR InterPro; IPR041899; MAGE_WH2.
DR InterPro; IPR030102; MAGEA10.
DR InterPro; IPR002190; MHD_dom.
DR PANTHER; PTHR11736; PTHR11736; 1.
DR PANTHER; PTHR11736:SF153; PTHR11736:SF153; 1.
DR Pfam; PF01454; MAGE; 1.
DR Pfam; PF12440; MAGE_N; 1.
DR SMART; SM01373; MAGE; 1.
DR SMART; SM01392; MAGE_N; 1.
DR PROSITE; PS50838; MAGE; 1.
PE 2: Evidence at transcript level;
KW Nucleus; Reference proteome; Tumor antigen.
FT CHAIN 1..369
FT /note="Melanoma-associated antigen 10"
FT /id="PRO_0000156709"
FT DOMAIN 134..333
FT /note="MAGE"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00127"
FT REGION 1..131
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 340..369
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 35..68
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 75..126
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 347..369
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 166
FT /note="R -> K (in dbSNP:rs210585)"
FT /evidence="ECO:0000269|PubMed:15489334,
FT ECO:0000269|PubMed:7927540"
FT /id="VAR_024528"
FT VARIANT 234
FT /note="V -> I (in dbSNP:rs210586)"
FT /evidence="ECO:0000269|PubMed:15489334,
FT ECO:0000269|PubMed:7927540"
FT /id="VAR_053496"
SQ SEQUENCE 369 AA; 40780 MW; 64FC72BBAF6F2DE6 CRC64;
MPRAPKRQRC MPEEDLQSQS ETQGLEGAQA PLAVEEDASS STSTSSSFPS SFPSSSSSSS
SSCYPLIPST PEEVSADDET PNPPQSAQIA CSSPSVVASL PLDQSDEGSS SQKEESPSTL
QVLPDSESLP RSEIDEKVTD LVQFLLFKYQ MKEPITKAEI LESVIRNYED HFPLLFSEAS
ECMLLVFGID VKEVDPTGHS FVLVTSLGLT YDGMLSDVQS MPKTGILILI LSIVFIEGYC
TPEEVIWEAL NMMGLYDGME HLIYGEPRKL LTQDWVQENY LEYRQVPGSD PARYEFLWGP
RAHAEIRKMS LLKFLAKVNG SDPRSFPLWY EEALKDEEER AQDRIATTDD TTAMASASSS
ATGSFSYPE
