ID   MAGA_MAGSA              Reviewed;         434 AA.
AC   Q2W031; Q50411;
DT   19-MAR-2014, integrated into UniProtKB/Swiss-Prot.
DT   10-JAN-2006, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Iron transporter MagA;
GN   Name=magA; OrderedLocusNames=amb3990;
OS   Magnetospirillum magneticum (strain AMB-1 / ATCC 700264).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodospirillales;
OC   Rhodospirillaceae; Magnetospirillum.
OX   NCBI_TaxID=342108;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION AS A TRANSPORTER.
RC   STRAIN=AMB-1 / ATCC 700264;
RX   PubMed=7499342; DOI=10.1074/jbc.270.47.28392;
RA   Nakamura C., Burgess G.J., Sode K., Matsunaga T.;
RT   "An iron-regulated gene, magA encoding an iron transport protein of
RT   Magnetospirillum sp. strain AMB-1.";
RL   J. Biol. Chem. 270:28392-28396(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AMB-1 / ATCC 700264;
RX   PubMed=16303747; DOI=10.1093/dnares/dsi002;
RA   Matsunaga T., Okamura Y., Fukuda Y., Wahyudi A.T., Murase Y., Takeyama H.;
RT   "Complete genome sequence of the facultative anaerobic magnetotactic
RT   bacterium Magnetospirillum sp. strain AMB-1.";
RL   DNA Res. 12:157-166(2005).
RN   [3]
RP   FUNCTION, SUBCELLULAR LOCATION, AND INDUCTION.
RC   STRAIN=AMB-1 / ATCC 700264;
RX   PubMed=8537318; DOI=10.1093/oxfordjournals.jbchem.a124884;
RA   Nakamura C., Kikuchi T., Burgess J., Matsunaga T.;
RT   "Iron-regulated expression and membrane localization of the magA protein in
RT   Magnetospirillum sp. strain AMB-1.";
RL   J. Biochem. 118:23-27(1995).
CC   -!- FUNCTION: Iron transporter, which is required for the synthesis of
CC       bacterial magnetic particles (BMPs). Probably involved in the transport
CC       of iron from the environment into the cytoplasm across the cell
CC       membrane, and then from the cytoplasm into the BMP lipid vesicle across
CC       the BMP membrane. {ECO:0000269|PubMed:7499342,
CC       ECO:0000269|PubMed:8537318}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:8537318}; Multi-pass
CC       membrane protein {ECO:0000269|PubMed:8537318}. Note=Present in the cell
CC       and bacterial magnetic particle membranes.
CC   -!- INDUCTION: Induced by low iron concentrations.
CC       {ECO:0000269|PubMed:8537318}.
CC   -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 2 (CPA2)
CC       transporter (TC 2.A.37) family. {ECO:0000305}.
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DR   EMBL; D32253; BAA06982.1; -; Genomic_DNA.
DR   EMBL; AP007255; BAE52794.1; -; Genomic_DNA.
DR   RefSeq; WP_011386344.1; NC_007626.1.
DR   AlphaFoldDB; Q2W031; -.
DR   SMR; Q2W031; -.
DR   TCDB; 2.A.37.1.12; the monovalent cation:proton antiporter-2 (cpa2) family.
DR   EnsemblBacteria; BAE52794; BAE52794; amb3990.
DR   KEGG; mag:amb3990; -.
DR   HOGENOM; CLU_005126_1_2_5; -.
DR   OMA; TTFSHEG; -.
DR   OrthoDB; 941006at2; -.
DR   Proteomes; UP000007058; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008324; F:cation transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015299; F:solute:proton antiporter activity; IEA:InterPro.
DR   GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1530.20; -; 1.
DR   InterPro; IPR006153; Cation/H_exchanger.
DR   InterPro; IPR004771; K/H_exchanger.
DR   InterPro; IPR038770; Na+/solute_symporter_sf.
DR   Pfam; PF00999; Na_H_Exchanger; 1.
DR   TIGRFAMs; TIGR00932; 2a37; 1.
PE   1: Evidence at protein level;
KW   Antiport; Ion transport; Iron; Iron transport; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..434
FT                   /note="Iron transporter MagA"
FT                   /id="PRO_0000425661"
FT   TRANSMEM        6..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        31..51
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        56..76
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        86..106
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        113..133
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        176..196
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        269..289
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        294..314
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        321..341
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        357..377
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   434 AA;  46828 MW;  1E183ABDF4150BE2 CRC64;
     MELHHPELTY AAIVALAAVL CGGMMTRLKQ PAVVGYILAG VVLGPSGFGL VSNRDAVATL
     AEFGVLMLLF VIGMKLDIIR FLEVWKTAIF TTVLQIAGSV GTALLLRHGL GWSLGLAVVL
     GCAVAVSSTA VVIKVLESSD ELDTPVGRTT LGILIAQDMA VVPMMLVLES FETKALLPAD
     MARVVLSVLF LVLLFWWLSK RRIDLPITAR LSRDSDLATL STLAWCFGTA AISGVLDLSP
     AYGAFLGGVV LGNSAQRDML LKRAQPIGSV LLMVFFLSIG LLLDFKFIWK NLGTVLTLLA
     MVTLFKTALN VTALRLARQD WPSAFLAGVA LAQIGEFSFL LAETGKAVKL ISAQETKLVV
     AVTVLSLVLS PFWLFTMRRM HRVAAVHVHS FRDLVTRLYG DEARAFARTA RRARVLVRRG
     SWRDDPNAGP GSGI