MAGB2_XENBO
ID MAGB2_XENBO Reviewed; 23 AA.
AC C0HK84;
DT 30-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT 30-NOV-2016, sequence version 1.
DT 25-MAY-2022, entry version 4.
DE RecName: Full=Magainin-B2 {ECO:0000303|PubMed:20656059};
OS Xenopus borealis (Kenyan clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8354 {ECO:0000303|PubMed:20656059};
RN [1] {ECO:0000305}
RP PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, AND MASS SPECTROMETRY.
RC TISSUE=Skin secretion {ECO:0000303|PubMed:20656059};
RX PubMed=20656059; DOI=10.1016/j.cbpc.2010.07.007;
RA Mechkarska M., Ahmed E., Coquet L., Leprince J., Jouenne T., Vaudry H.,
RA King J.D., Conlon J.M.;
RT "Antimicrobial peptides with therapeutic potential from skin secretions of
RT the Marsabit clawed frog Xenopus borealis (Pipidae).";
RL Comp. Biochem. Physiol. 152:467-472(2010).
CC -!- FUNCTION: Has antimicrobial activity against Gram-negative bacterium
CC E.coli ATCC 25922 (MIC=50 uM) and against fungus C.albicans ATCC 90028
CC (MIC=100 uM). Has no hemolytic activity against human erythrocytes even
CC at high concentrations. {ECO:0000269|PubMed:20656059}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:20656059}.
CC -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC {ECO:0000305|PubMed:20656059}.
CC -!- MASS SPECTROMETRY: Mass=2409.5; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:20656059};
CC -!- SIMILARITY: Belongs to the gastrin/cholecystokinin family. Magainin
CC subfamily. {ECO:0000305}.
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DR AlphaFoldDB; C0HK84; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR GO; GO:0050832; P:defense response to fungus; IEA:UniProtKB-KW.
DR GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Antibiotic; Antimicrobial; Direct protein sequencing; Fungicide; Secreted.
FT PEPTIDE 1..23
FT /note="Magainin-B2"
FT /evidence="ECO:0000269|PubMed:20656059"
FT /id="PRO_0000438424"
SQ SEQUENCE 23 AA; 2410 MW; 62065E72745D4346 CRC64;
GIGKFLHSAG KFGKAFLGEV MKS