MAGB3_HUMAN
ID MAGB3_HUMAN Reviewed; 346 AA.
AC O15480; A0AVE4; B3KQ52; O75861;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 05-MAY-2009, sequence version 2.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Melanoma-associated antigen B3;
DE AltName: Full=MAGE-B3 antigen;
GN Name=MAGEB3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS HIS-107 AND THR-112.
RX PubMed=9441743; DOI=10.1006/geno.1997.5052;
RA Lurquin C., De Smet C., Brasseur F., Muscatelli F., Martelange V.,
RA De Plaen E., Brasseur R., Monaco A.P., Boon T.;
RT "Two members of the human MAGEB gene family located in Xp21.3 are expressed
RT in tumors of various histological origins.";
RL Genomics 46:397-408(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS HIS-107 AND THR-112.
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS HIS-107 AND THR-112.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC O15480; Q8WXH2: JPH3; NbExp=3; IntAct=EBI-21634885, EBI-1055254;
CC -!- TISSUE SPECIFICITY: Expressed in testis.
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DR EMBL; U93163; AAC23618.1; -; Genomic_DNA.
DR EMBL; AK057441; BAG51914.1; -; mRNA.
DR EMBL; AC005185; AAD10636.1; -; Genomic_DNA.
DR EMBL; BC069784; AAH69784.1; -; mRNA.
DR EMBL; BC074756; AAH74756.1; -; mRNA.
DR EMBL; BC126320; AAI26321.1; -; mRNA.
DR EMBL; BC126322; AAI26323.1; -; mRNA.
DR CCDS; CCDS14220.1; -.
DR RefSeq; NP_002356.2; NM_002365.4.
DR RefSeq; XP_011543815.1; XM_011545513.2.
DR RefSeq; XP_011543816.1; XM_011545514.2.
DR AlphaFoldDB; O15480; -.
DR SMR; O15480; -.
DR BioGRID; 110288; 3.
DR IntAct; O15480; 3.
DR STRING; 9606.ENSP00000355198; -.
DR iPTMnet; O15480; -.
DR PhosphoSitePlus; O15480; -.
DR BioMuta; MAGEB3; -.
DR EPD; O15480; -.
DR MassIVE; O15480; -.
DR MaxQB; O15480; -.
DR PaxDb; O15480; -.
DR PeptideAtlas; O15480; -.
DR PRIDE; O15480; -.
DR ProteomicsDB; 48685; -.
DR Antibodypedia; 24658; 202 antibodies from 25 providers.
DR DNASU; 4114; -.
DR Ensembl; ENST00000361644.4; ENSP00000355198.2; ENSG00000198798.6.
DR Ensembl; ENST00000620842.1; ENSP00000478513.1; ENSG00000198798.6.
DR GeneID; 4114; -.
DR KEGG; hsa:4114; -.
DR MANE-Select; ENST00000361644.4; ENSP00000355198.2; NM_002365.5; NP_002356.2.
DR UCSC; uc004dca.3; human.
DR CTD; 4114; -.
DR GeneCards; MAGEB3; -.
DR HGNC; HGNC:6810; MAGEB3.
DR HPA; ENSG00000198798; Group enriched (epididymis, testis).
DR MIM; 300152; gene.
DR neXtProt; NX_O15480; -.
DR OpenTargets; ENSG00000198798; -.
DR PharmGKB; PA30556; -.
DR VEuPathDB; HostDB:ENSG00000198798; -.
DR eggNOG; KOG4562; Eukaryota.
DR GeneTree; ENSGT00940000164194; -.
DR HOGENOM; CLU_039582_1_0_1; -.
DR InParanoid; O15480; -.
DR OMA; WAKVNQT; -.
DR OrthoDB; 1195799at2759; -.
DR PhylomeDB; O15480; -.
DR TreeFam; TF328505; -.
DR PathwayCommons; O15480; -.
DR SignaLink; O15480; -.
DR BioGRID-ORCS; 4114; 11 hits in 682 CRISPR screens.
DR GenomeRNAi; 4114; -.
DR Pharos; O15480; Tdark.
DR PRO; PR:O15480; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; O15480; protein.
DR Bgee; ENSG00000198798; Expressed in right testis and 6 other tissues.
DR Genevisible; O15480; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.10.1200; -; 1.
DR Gene3D; 1.10.10.1210; -; 1.
DR InterPro; IPR037445; MAGE.
DR InterPro; IPR021072; MAGE_N.
DR InterPro; IPR041898; MAGE_WH1.
DR InterPro; IPR041899; MAGE_WH2.
DR InterPro; IPR002190; MHD_dom.
DR PANTHER; PTHR11736; PTHR11736; 1.
DR Pfam; PF01454; MAGE; 1.
DR Pfam; PF12440; MAGE_N; 1.
DR SMART; SM01373; MAGE; 1.
DR SMART; SM01392; MAGE_N; 1.
DR PROSITE; PS50838; MAGE; 1.
PE 1: Evidence at protein level;
KW Reference proteome; Tumor antigen.
FT CHAIN 1..346
FT /note="Melanoma-associated antigen B3"
FT /id="PRO_0000156714"
FT DOMAIN 111..310
FT /note="MAGE"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00127"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..35
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 107
FT /note="R -> H (in dbSNP:rs2071308)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:9441743"
FT /id="VAR_021360"
FT VARIANT 112
FT /note="I -> T (in dbSNP:rs2071309)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:9441743"
FT /id="VAR_021361"
SQ SEQUENCE 346 AA; 39211 MW; 053407C60CBEFFE5 CRC64;
MPRGQKSTLH AREKRQQTRG QTQDHQGAQI TATNKKKVSF SSPLILGATI QKKSAGRSRS
ALKKPQRALS TTTSVDVSYK KSYKGANSKI EKKQSFSQGL SSTVQSRTDP LIMKTNMLVQ
FLMEMYKMKK PIMKADMLKI VQKSHKNCFP EILKKASFNM EVVFGVDLKK VDSTKDSYVL
VSKMDLPNNG TVTRGRGFPK TGLLLNLLGV IFMKGNCATE EKIWEFLNKM RIYDGKKHFI
FGEPRKLITQ DLVKLKYLEY RQVPNSNPAR YEFLWGPRAH AETSKMKVLE FWAKVNKTVP
SAFQFWYEEA LRDEEERVQA AAMLNDGSSA MGRKCSKAKA SSSSHA
