MAGB4_HUMAN
ID MAGB4_HUMAN Reviewed; 346 AA.
AC O15481; B2R9G0; Q6FHH4; Q8IZ00;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Melanoma-associated antigen B4;
DE AltName: Full=MAGE-B4 antigen;
GN Name=MAGEB4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9441743; DOI=10.1006/geno.1997.5052;
RA Lurquin C., De Smet C., Brasseur F., Muscatelli F., Martelange V.,
RA De Plaen E., Brasseur R., Monaco A.P., Boon T.;
RT "Two members of the human MAGEB gene family located in Xp21.3 are expressed
RT in tumors of various histological origins.";
RL Genomics 46:397-408(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P.,
RA Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y.,
RA LaBaer J.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC O15481; Q4LEZ3: AARD; NbExp=3; IntAct=EBI-751857, EBI-5463075;
CC O15481; Q8WXI4-2: ACOT11; NbExp=3; IntAct=EBI-751857, EBI-17721098;
CC O15481; Q99856: ARID3A; NbExp=3; IntAct=EBI-751857, EBI-5458244;
CC O15481; P78537: BLOC1S1; NbExp=3; IntAct=EBI-751857, EBI-348630;
CC O15481; Q96JN2-2: CCDC136; NbExp=3; IntAct=EBI-751857, EBI-10171416;
CC O15481; Q49A88-3: CCDC14; NbExp=3; IntAct=EBI-751857, EBI-12105646;
CC O15481; Q92997: DVL3; NbExp=3; IntAct=EBI-751857, EBI-739789;
CC O15481; Q96AZ1: EEF1AKMT3; NbExp=3; IntAct=EBI-751857, EBI-12108304;
CC O15481; Q96C01: FAM136A; NbExp=3; IntAct=EBI-751857, EBI-373319;
CC O15481; A8MTA8-2: FAM166B; NbExp=5; IntAct=EBI-751857, EBI-12160437;
CC O15481; Q96RJ6: FERD3L; NbExp=3; IntAct=EBI-751857, EBI-10183007;
CC O15481; Q9BTI6: FLOT2; NbExp=3; IntAct=EBI-751857, EBI-23703366;
CC O15481; Q8N9W4-2: GOLGA6L2; NbExp=3; IntAct=EBI-751857, EBI-10268729;
CC O15481; Q9NW75-2: GPATCH2; NbExp=3; IntAct=EBI-751857, EBI-12068108;
CC O15481; O75409: H2AP; NbExp=3; IntAct=EBI-751857, EBI-6447217;
CC O15481; O14964: HGS; NbExp=3; IntAct=EBI-751857, EBI-740220;
CC O15481; Q8IYA8: IHO1; NbExp=3; IntAct=EBI-751857, EBI-8638439;
CC O15481; Q63ZY3: KANK2; NbExp=6; IntAct=EBI-751857, EBI-2556193;
CC O15481; O76015: KRT38; NbExp=5; IntAct=EBI-751857, EBI-1047263;
CC O15481; Q9BRK4: LZTS2; NbExp=3; IntAct=EBI-751857, EBI-741037;
CC O15481; P43361: MAGEA8; NbExp=3; IntAct=EBI-751857, EBI-10182930;
CC O15481; Q13503: MED21; NbExp=6; IntAct=EBI-751857, EBI-394678;
CC O15481; Q14696: MESD; NbExp=3; IntAct=EBI-751857, EBI-6165891;
CC O15481; Q9HD90: NEUROD4; NbExp=5; IntAct=EBI-751857, EBI-3917781;
CC O15481; O15212: PFDN6; NbExp=3; IntAct=EBI-751857, EBI-356973;
CC O15481; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-751857, EBI-79165;
CC O15481; Q13464: ROCK1; NbExp=4; IntAct=EBI-751857, EBI-876651;
CC O15481; Q59EK9: RUNDC3A; NbExp=3; IntAct=EBI-751857, EBI-747225;
CC O15481; Q59EK9-3: RUNDC3A; NbExp=3; IntAct=EBI-751857, EBI-11957366;
CC O15481; O14796: SH2D1B; NbExp=3; IntAct=EBI-751857, EBI-3923013;
CC O15481; Q96FV9: THOC1; NbExp=3; IntAct=EBI-751857, EBI-1765605;
CC O15481; A1L306: TNR; NbExp=3; IntAct=EBI-751857, EBI-10182881;
CC O15481; P14927: UQCRB; NbExp=3; IntAct=EBI-751857, EBI-743128;
CC O15481; Q8N6Y0: USHBP1; NbExp=6; IntAct=EBI-751857, EBI-739895;
CC O15481; Q9UHP3: USP25; NbExp=3; IntAct=EBI-751857, EBI-2513462;
CC O15481; O43379: WDR62; NbExp=3; IntAct=EBI-751857, EBI-714790;
CC O15481; Q9BYN7: ZNF341; NbExp=3; IntAct=EBI-751857, EBI-9089622;
CC O15481; Q9UGI0: ZRANB1; NbExp=3; IntAct=EBI-751857, EBI-527853;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:A2A9R3}.
CC -!- TISSUE SPECIFICITY: Expressed in testis.
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DR EMBL; U93163; AAC23619.1; -; Genomic_DNA.
DR EMBL; CR541779; CAG46578.1; -; mRNA.
DR EMBL; AK313769; BAG36507.1; -; mRNA.
DR EMBL; AC005185; AAD10637.1; -; Genomic_DNA.
DR EMBL; CH471074; EAW99050.1; -; Genomic_DNA.
DR EMBL; BC032852; AAH32852.1; -; mRNA.
DR CCDS; CCDS14221.1; -.
DR RefSeq; NP_002358.1; NM_002367.3.
DR AlphaFoldDB; O15481; -.
DR SMR; O15481; -.
DR BioGRID; 110289; 64.
DR IntAct; O15481; 43.
DR STRING; 9606.ENSP00000368266; -.
DR GlyGen; O15481; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; O15481; -.
DR PhosphoSitePlus; O15481; -.
DR BioMuta; MAGEB4; -.
DR MassIVE; O15481; -.
DR MaxQB; O15481; -.
DR PaxDb; O15481; -.
DR PeptideAtlas; O15481; -.
DR PRIDE; O15481; -.
DR ProteomicsDB; 48686; -.
DR Antibodypedia; 24659; 235 antibodies from 28 providers.
DR DNASU; 4115; -.
DR Ensembl; ENST00000378982.4; ENSP00000368266.2; ENSG00000120289.12.
DR GeneID; 4115; -.
DR KEGG; hsa:4115; -.
DR MANE-Select; ENST00000378982.4; ENSP00000368266.2; NM_002367.4; NP_002358.1.
DR UCSC; uc004dcb.4; human.
DR CTD; 4115; -.
DR DisGeNET; 4115; -.
DR GeneCards; MAGEB4; -.
DR HGNC; HGNC:6811; MAGEB4.
DR HPA; ENSG00000120289; Group enriched (epididymis, testis).
DR MIM; 300153; gene.
DR neXtProt; NX_O15481; -.
DR OpenTargets; ENSG00000120289; -.
DR PharmGKB; PA30557; -.
DR VEuPathDB; HostDB:ENSG00000120289; -.
DR eggNOG; KOG4562; Eukaryota.
DR GeneTree; ENSGT00940000165012; -.
DR HOGENOM; CLU_039582_1_0_1; -.
DR InParanoid; O15481; -.
DR OMA; NGNCARE; -.
DR OrthoDB; 1195799at2759; -.
DR PhylomeDB; O15481; -.
DR TreeFam; TF328505; -.
DR PathwayCommons; O15481; -.
DR SignaLink; O15481; -.
DR BioGRID-ORCS; 4115; 8 hits in 691 CRISPR screens.
DR GenomeRNAi; 4115; -.
DR Pharos; O15481; Tdark.
DR PRO; PR:O15481; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; O15481; protein.
DR Bgee; ENSG00000120289; Expressed in corpus epididymis and 16 other tissues.
DR Genevisible; O15481; HS.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.10.1200; -; 1.
DR Gene3D; 1.10.10.1210; -; 1.
DR InterPro; IPR037445; MAGE.
DR InterPro; IPR021072; MAGE_N.
DR InterPro; IPR041898; MAGE_WH1.
DR InterPro; IPR041899; MAGE_WH2.
DR InterPro; IPR002190; MHD_dom.
DR PANTHER; PTHR11736; PTHR11736; 1.
DR Pfam; PF01454; MAGE; 1.
DR Pfam; PF12440; MAGE_N; 1.
DR SMART; SM01373; MAGE; 1.
DR SMART; SM01392; MAGE_N; 1.
DR PROSITE; PS50838; MAGE; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Reference proteome; Tumor antigen.
FT CHAIN 1..346
FT /note="Melanoma-associated antigen B4"
FT /id="PRO_0000156715"
FT DOMAIN 109..307
FT /note="MAGE"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00127"
FT REGION 1..107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 311..346
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..76
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 90..104
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 328..346
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 41
FT /note="S -> P (in Ref. 6; AAH32852)"
FT /evidence="ECO:0000305"
FT CONFLICT 186
FT /note="D -> Y (in Ref. 6; AAH32852)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 346 AA; 38923 MW; 804F260BD50F036A CRC64;
MPRGQKSKLR AREKRQRTRG QTQDLKVGQP TAAEKEESPS SSSSVLRDTA SSSLAFGIPQ
EPQREPPTTS AAAAMSCTGS DKGDESQDEE NASSSQASTS TERSLKDSLT RKTKMLVQFL
LYKYKMKEPT TKAEMLKIIS KKYKEHFPEI FRKVSQRTEL VFGLALKEVN PTTHSYILVS
MLGPNDGNQS SAWTLPRNGL LMPLLSVIFL NGNCAREEEI WEFLNMLGIY DGKRHLIFGE
PRKLITQDLV QEKYLEYQQV PNSDPPRYQF LWGPRAHAET SKMKVLEFLA KVNDTTPNNF
PLLYEEALRD EEERAGARPR VAARRGTTAM TSAYSRATSS SSSQPM
