MAGB5_HUMAN
ID MAGB5_HUMAN Reviewed; 275 AA.
AC Q9BZ81;
DT 16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT 11-SEP-2007, sequence version 2.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Melanoma-associated antigen B5;
DE AltName: Full=Cancer/testis antigen 3.3;
DE Short=CT3.3;
DE AltName: Full=MAGE-B5 antigen;
GN Name=MAGEB5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 125-235.
RC TISSUE=Blood;
RX PubMed=10861452;
RX DOI=10.1002/1097-0215(20000701)87:1<55::aid-ijc8>3.0.co;2-j;
RA Lucas S., De Plaen E., Boon T.;
RT "MAGE-B5, MAGE-B6, MAGE-C2, and MAGE-C3: four new members of the MAGE
RT family with tumor-specific expression.";
RL Int. J. Cancer 87:55-60(2000).
CC -!- TISSUE SPECIFICITY: Expressed in testis. Not expressed in other normal
CC tissues, but is expressed in tumors of different histological origins.
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DR EMBL; AF333705; AAK00357.1; -; Genomic_DNA.
DR CCDS; CCDS65233.1; -.
DR RefSeq; NP_001258681.1; NM_001271752.1.
DR AlphaFoldDB; Q9BZ81; -.
DR SMR; Q9BZ81; -.
DR BioGRID; 131448; 1.
DR IntAct; Q9BZ81; 1.
DR STRING; 9606.ENSP00000473493; -.
DR iPTMnet; Q9BZ81; -.
DR PhosphoSitePlus; Q9BZ81; -.
DR BioMuta; MAGEB5; -.
DR MassIVE; Q9BZ81; -.
DR PaxDb; Q9BZ81; -.
DR PeptideAtlas; Q9BZ81; -.
DR PRIDE; Q9BZ81; -.
DR Antibodypedia; 64767; 32 antibodies from 15 providers.
DR DNASU; 347541; -.
DR Ensembl; ENST00000602297.1; ENSP00000473493.1; ENSG00000188408.5.
DR GeneID; 347541; -.
DR KEGG; hsa:347541; -.
DR MANE-Select; ENST00000602297.1; ENSP00000473493.1; NM_001271752.1; NP_001258681.1.
DR UCSC; uc031thc.1; human.
DR CTD; 347541; -.
DR DisGeNET; 347541; -.
DR GeneCards; MAGEB5; -.
DR HGNC; HGNC:23795; MAGEB5.
DR HPA; ENSG00000188408; Not detected.
DR MIM; 300466; gene.
DR neXtProt; NX_Q9BZ81; -.
DR OpenTargets; ENSG00000188408; -.
DR VEuPathDB; HostDB:ENSG00000188408; -.
DR eggNOG; KOG4562; Eukaryota.
DR GeneTree; ENSGT00940000163033; -.
DR HOGENOM; CLU_039582_1_3_1; -.
DR InParanoid; Q9BZ81; -.
DR OMA; KIVNPRY; -.
DR OrthoDB; 1195799at2759; -.
DR PhylomeDB; Q9BZ81; -.
DR TreeFam; TF328505; -.
DR PathwayCommons; Q9BZ81; -.
DR SignaLink; Q9BZ81; -.
DR BioGRID-ORCS; 347541; 13 hits in 640 CRISPR screens.
DR GenomeRNAi; 347541; -.
DR Pharos; Q9BZ81; Tdark.
DR PRO; PR:Q9BZ81; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q9BZ81; protein.
DR Bgee; ENSG00000188408; Expressed in left testis and 1 other tissue.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.10.1200; -; 1.
DR Gene3D; 1.10.10.1210; -; 1.
DR InterPro; IPR037445; MAGE.
DR InterPro; IPR041898; MAGE_WH1.
DR InterPro; IPR041899; MAGE_WH2.
DR InterPro; IPR030085; MAGEB5.
DR InterPro; IPR002190; MHD_dom.
DR PANTHER; PTHR11736; PTHR11736; 1.
DR PANTHER; PTHR11736:SF35; PTHR11736:SF35; 1.
DR Pfam; PF01454; MAGE; 1.
DR SMART; SM01373; MAGE; 1.
DR PROSITE; PS50838; MAGE; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; Tumor antigen.
FT CHAIN 1..275
FT /note="Melanoma-associated antigen B5"
FT /id="PRO_0000156716"
FT DOMAIN 40..239
FT /note="MAGE"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00127"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 275 AA; 31906 MW; 57EDE75D76D07004 CRC64;
MTSAGVFNAG SDERANSRDE EYPCSSEVSP STESSCSNFI NIKVGLLEQF LLYKFKMKQR
ILKEDMLKIV NPRYQNQFAE IHRRASEHIE VVFAVDLKEV NPTCHLYDLV SKLKLPNNGR
IHVGKVLPKT GLLMTFLVVI FLKGNCANKE DTWKFLDMMQ IYDGKKYYIY GEPRKLITQD
FVRLTYLEYH QVPCSYPAHY QFLWGPRAYT ETSKMKVLEY LAKVNDIAPG AFSSQYEEAL
QDEEESPSQR CSRNWHYCSG QDCLRAKFSS FSQPY
