MAGB6_HUMAN
ID MAGB6_HUMAN Reviewed; 407 AA.
AC Q8N7X4; Q6GS19; Q9H219;
DT 16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2005, sequence version 2.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Melanoma-associated antigen B6;
DE AltName: Full=Cancer/testis antigen 3.4;
DE Short=CT3.4;
DE AltName: Full=MAGE-B6 antigen;
GN Name=MAGEB6;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 49-177, AND TISSUE SPECIFICITY.
RC TISSUE=Blood;
RX PubMed=10861452;
RX DOI=10.1002/1097-0215(20000701)87:1<55::aid-ijc8>3.0.co;2-j;
RA Lucas S., De Plaen E., Boon T.;
RT "MAGE-B5, MAGE-B6, MAGE-C2, and MAGE-C3: four new members of the MAGE
RT family with tumor-specific expression.";
RL Int. J. Cancer 87:55-60(2000).
CC -!- INTERACTION:
CC Q8N7X4; Q6NUP5: AGTR1; NbExp=3; IntAct=EBI-6447163, EBI-10232010;
CC Q8N7X4; Q99767-2: APBA2; NbExp=3; IntAct=EBI-6447163, EBI-12218351;
CC Q8N7X4; P42331-2: ARHGAP25; NbExp=3; IntAct=EBI-6447163, EBI-21499901;
CC Q8N7X4; Q8WUW1: BRK1; NbExp=3; IntAct=EBI-6447163, EBI-2837444;
CC Q8N7X4; P50990: CCT8; NbExp=3; IntAct=EBI-6447163, EBI-356507;
CC Q8N7X4; Q13286: CLN3; NbExp=3; IntAct=EBI-6447163, EBI-3248760;
CC Q8N7X4; O00429-3: DNM1L; NbExp=3; IntAct=EBI-6447163, EBI-6896746;
CC Q8N7X4; P29692-2: EEF1D; NbExp=3; IntAct=EBI-6447163, EBI-5280572;
CC Q8N7X4; P00451-2: F8; NbExp=3; IntAct=EBI-6447163, EBI-25852704;
CC Q8N7X4; Q06787-7: FMR1; NbExp=3; IntAct=EBI-6447163, EBI-25856644;
CC Q8N7X4; Q9UJ83: HACL1; NbExp=3; IntAct=EBI-6447163, EBI-746580;
CC Q8N7X4; P08238: HSP90AB1; NbExp=3; IntAct=EBI-6447163, EBI-352572;
CC Q8N7X4; P42858: HTT; NbExp=2; IntAct=EBI-6447163, EBI-466029;
CC Q8N7X4; Q8IXK0: PHC2; NbExp=3; IntAct=EBI-6447163, EBI-713786;
CC Q8N7X4; Q06830: PRDX1; NbExp=3; IntAct=EBI-6447163, EBI-353193;
CC Q8N7X4; Q2M1J3: ROBO1; NbExp=3; IntAct=EBI-6447163, EBI-18191632;
CC Q8N7X4; P01009: SERPINA1; NbExp=3; IntAct=EBI-6447163, EBI-986224;
CC Q8N7X4; Q11203: ST3GAL3; NbExp=3; IntAct=EBI-6447163, EBI-717142;
CC Q8N7X4; Q8IYB8: SUPV3L1; NbExp=3; IntAct=EBI-6447163, EBI-2876787;
CC Q8N7X4; O94811: TPPP; NbExp=3; IntAct=EBI-6447163, EBI-3927802;
CC -!- TISSUE SPECIFICITY: Expressed in testis. Not expressed in other normal
CC tissues, but is expressed in tumors of different histological origins.
CC {ECO:0000269|PubMed:10861452}.
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DR EMBL; AK097561; BAC05102.1; -; mRNA.
DR EMBL; BC067286; AAH67286.1; -; mRNA.
DR EMBL; BC074920; AAH74920.1; -; mRNA.
DR EMBL; AF320514; AAG48624.1; -; Genomic_DNA.
DR CCDS; CCDS14217.1; -.
DR RefSeq; NP_775794.2; NM_173523.2.
DR AlphaFoldDB; Q8N7X4; -.
DR SMR; Q8N7X4; -.
DR BioGRID; 127710; 10.
DR IntAct; Q8N7X4; 23.
DR STRING; 9606.ENSP00000368320; -.
DR GlyGen; Q8N7X4; 2 sites, 2 O-linked glycans (2 sites).
DR iPTMnet; Q8N7X4; -.
DR PhosphoSitePlus; Q8N7X4; -.
DR BioMuta; MAGEB6; -.
DR DMDM; 84027854; -.
DR jPOST; Q8N7X4; -.
DR MassIVE; Q8N7X4; -.
DR PaxDb; Q8N7X4; -.
DR PeptideAtlas; Q8N7X4; -.
DR PRIDE; Q8N7X4; -.
DR ProteomicsDB; 72345; -.
DR Antibodypedia; 24623; 92 antibodies from 20 providers.
DR DNASU; 158809; -.
DR Ensembl; ENST00000379034.1; ENSP00000368320.1; ENSG00000176746.6.
DR GeneID; 158809; -.
DR KEGG; hsa:158809; -.
DR MANE-Select; ENST00000379034.1; ENSP00000368320.1; NM_173523.2; NP_775794.2.
DR UCSC; uc004dbr.3; human.
DR CTD; 158809; -.
DR DisGeNET; 158809; -.
DR GeneCards; MAGEB6; -.
DR HGNC; HGNC:23796; MAGEB6.
DR HPA; ENSG00000176746; Tissue enriched (testis).
DR MIM; 300467; gene.
DR neXtProt; NX_Q8N7X4; -.
DR OpenTargets; ENSG00000176746; -.
DR PharmGKB; PA134864191; -.
DR VEuPathDB; HostDB:ENSG00000176746; -.
DR eggNOG; KOG4562; Eukaryota.
DR GeneTree; ENSGT00940000159951; -.
DR HOGENOM; CLU_039582_1_0_1; -.
DR InParanoid; Q8N7X4; -.
DR OMA; QKAIIFK; -.
DR OrthoDB; 1195799at2759; -.
DR PhylomeDB; Q8N7X4; -.
DR TreeFam; TF328505; -.
DR PathwayCommons; Q8N7X4; -.
DR SignaLink; Q8N7X4; -.
DR BioGRID-ORCS; 158809; 16 hits in 694 CRISPR screens.
DR GenomeRNAi; 158809; -.
DR Pharos; Q8N7X4; Tdark.
DR PRO; PR:Q8N7X4; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q8N7X4; protein.
DR Bgee; ENSG00000176746; Expressed in right testis and 3 other tissues.
DR Genevisible; Q8N7X4; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.10.1200; -; 1.
DR Gene3D; 1.10.10.1210; -; 1.
DR InterPro; IPR037445; MAGE.
DR InterPro; IPR021072; MAGE_N.
DR InterPro; IPR041898; MAGE_WH1.
DR InterPro; IPR041899; MAGE_WH2.
DR InterPro; IPR002190; MHD_dom.
DR PANTHER; PTHR11736; PTHR11736; 1.
DR Pfam; PF01454; MAGE; 1.
DR Pfam; PF12440; MAGE_N; 1.
DR SMART; SM01373; MAGE; 1.
DR SMART; SM01392; MAGE_N; 2.
DR PROSITE; PS50838; MAGE; 1.
PE 1: Evidence at protein level;
KW Reference proteome; Tumor antigen.
FT CHAIN 1..407
FT /note="Melanoma-associated antigen B6"
FT /id="PRO_0000156717"
FT DOMAIN 195..394
FT /note="MAGE"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00127"
FT REGION 1..175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..50
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 57..117
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 131..159
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 172
FT /note="G -> R (in Ref. 1; BAC05102)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 407 AA; 43992 MW; 3674F422020355DA CRC64;
MPRGHKSKLR TCEKRQETNG QPQGLTGPQA TAEKQEESHS SSSSSRACLG DCRRSSDASI
PQESQGVSPT GSPDAVVSYS KSDVAANGQD EKSPSTSRDA SVPQESQGAS PTGSPDAGVS
GSKYDVAANG QDEKSPSTSH DVSVPQESQG ASPTGSPDAG VSGSKYDVAA EGEDEESVSA
SQKAIIFKRL SKDAVKKKAC TLAQFLQKKF EKKESILKAD MLKCVRREYK PYFPQILNRT
SQHLVVAFGV ELKEMDSSGE SYTLVSKLGL PSEGILSGDN ALPKSGLLMS LLVVIFMNGN
CATEEEVWEF LGLLGIYDGI LHSIYGDARK IITEDLVQDK YVVYRQVCNS DPPCYEFLWG
PRAYAETTKM RVLRVLADSS NTSPGLYPHL YEDALIDEVE RALRLRA
