ID   MAGBA_CANLF             Reviewed;         378 AA.
AC   Q9TTY4;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Melanoma-associated antigen B10;
DE   AltName: Full=MAGE-B10 antigen;
GN   Name=MAGEB10;
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   STRAIN=Beagle; TISSUE=Testis;
RX   PubMed=11019919; DOI=10.1034/j.1399-0039.2000.560210.x;
RA   Ma Z., Khatlani T.S., Ohno K., Sasaki K., Inokuma H., Onishi T.;
RT   "Cloning and sequencing of canine MAGE cDNA.";
RL   Tissue Antigens 56:166-169(2000).
CC   -!- TISSUE SPECIFICITY: Detected only in the melanoma and testis and not in
CC       other normal tissues. {ECO:0000269|PubMed:11019919}.
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DR   EMBL; AF187325; AAF01438.1; -; mRNA.
DR   RefSeq; NP_001003116.1; NM_001003116.1.
DR   AlphaFoldDB; Q9TTY4; -.
DR   SMR; Q9TTY4; -.
DR   STRING; 9612.ENSCAFP00000020016; -.
DR   PaxDb; Q9TTY4; -.
DR   PRIDE; Q9TTY4; -.
DR   Ensembl; ENSCAFT00030040596; ENSCAFP00030035437; ENSCAFG00030022111.
DR   Ensembl; ENSCAFT00040021022; ENSCAFP00040018255; ENSCAFG00040011382.
DR   Ensembl; ENSCAFT00845054908; ENSCAFP00845043180; ENSCAFG00845030893.
DR   GeneID; 403710; -.
DR   KEGG; cfa:403710; -.
DR   CTD; 139422; -.
DR   VEuPathDB; HostDB:ENSCAFG00845030893; -.
DR   eggNOG; KOG4562; Eukaryota.
DR   GeneTree; ENSGT00940000167876; -.
DR   HOGENOM; CLU_039582_1_0_1; -.
DR   InParanoid; Q9TTY4; -.
DR   OMA; LYEGRKH; -.
DR   OrthoDB; 1195799at2759; -.
DR   TreeFam; TF328505; -.
DR   Proteomes; UP000002254; Chromosome X.
DR   Bgee; ENSCAFG00000013604; Expressed in testis and 1 other tissue.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 1.10.10.1200; -; 1.
DR   Gene3D; 1.10.10.1210; -; 1.
DR   InterPro; IPR037445; MAGE.
DR   InterPro; IPR021072; MAGE_N.
DR   InterPro; IPR041898; MAGE_WH1.
DR   InterPro; IPR041899; MAGE_WH2.
DR   InterPro; IPR002190; MHD_dom.
DR   PANTHER; PTHR11736; PTHR11736; 1.
DR   Pfam; PF01454; MAGE; 1.
DR   Pfam; PF12440; MAGE_N; 1.
DR   SMART; SM01373; MAGE; 1.
DR   SMART; SM01392; MAGE_N; 1.
DR   PROSITE; PS50838; MAGE; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Tumor antigen.
FT   CHAIN           1..378
FT                   /note="Melanoma-associated antigen B10"
FT                   /id="PRO_0000311927"
FT   DOMAIN          108..307
FT                   /note="MAGE"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00127"
FT   REGION          49..105
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        49..81
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   378 AA;  42214 MW;  AD09C6DC8E3C8D57 CRC64;
     MPRGQKSKLR ACKKRRQVRE ELQDLVGAQA TAAVGEVFHS PSSLCFKSSP AAGSYSVSQG
     PQGAISTSTT AASVSHTRSN ESADNQVEER PRSSQAQPTA EPFPRGPLDE KVVKLVHYLL
     YKYQMKELIS KAGMLRNVIQ MYRNHFHEIL KRASEHLELV FGLDLKEVDP NRHIYVLVNK
     LELSYDAMLS DDEGVPKTGL LMTILGVIFT KGNCAAEEQV WQVLNVIGLY AGMEHFIFGE
     PRKLITEDLV KEEYLEYRQV ANSDPPRYEF LWGPRAYAET SKMKVLEFLA KVHYTVPSAF
     PAWYEEALQD EEERAQARAA ARAHTAAMAS ARARAMTSAH SKGITNEHSR AMTNVHSRAI
     ASVRSKATQT IPPTPNKV