MAGBA_HUMAN
ID MAGBA_HUMAN Reviewed; 347 AA.
AC Q96LZ2; Q494Y6; Q494Y7; Q9BZ78;
DT 25-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT 03-MAR-2009, sequence version 4.
DT 25-MAY-2022, entry version 126.
DE RecName: Full=Melanoma-associated antigen B10;
DE AltName: Full=MAGE-B10 antigen;
GN Name=MAGEB10;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS SER-50 AND GLN-65.
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS SER-50 AND GLN-65.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 53-222.
RC TISSUE=Blood;
RA Lucas S., Boon T.;
RT "Identification of new members of the MAGE gene family.";
RL Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases.
CC -!- INTERACTION:
CC Q96LZ2; P51687: SUOX; NbExp=5; IntAct=EBI-3957156, EBI-3921347;
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DR EMBL; AK057527; BAB71522.1; -; mRNA.
DR EMBL; AC107613; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC112492; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC101307; AAI01308.1; -; mRNA.
DR EMBL; BC101308; AAI01309.1; -; mRNA.
DR EMBL; BC101309; AAI01310.1; -; mRNA.
DR EMBL; BC101310; AAI01311.1; -; mRNA.
DR EMBL; AF333708; AAK00360.1; -; Genomic_DNA.
DR CCDS; CCDS35221.1; -.
DR RefSeq; NP_872312.2; NM_182506.3.
DR AlphaFoldDB; Q96LZ2; -.
DR SMR; Q96LZ2; -.
DR BioGRID; 126566; 66.
DR IntAct; Q96LZ2; 51.
DR STRING; 9606.ENSP00000368304; -.
DR iPTMnet; Q96LZ2; -.
DR PhosphoSitePlus; Q96LZ2; -.
DR BioMuta; MAGEB10; -.
DR DMDM; 224471901; -.
DR MassIVE; Q96LZ2; -.
DR MaxQB; Q96LZ2; -.
DR PaxDb; Q96LZ2; -.
DR PeptideAtlas; Q96LZ2; -.
DR PRIDE; Q96LZ2; -.
DR ProteomicsDB; 77270; -.
DR Antibodypedia; 397; 140 antibodies from 24 providers.
DR DNASU; 139422; -.
DR Ensembl; ENST00000356790.2; ENSP00000368304.1; ENSG00000177689.10.
DR Ensembl; ENST00000614159.1; ENSP00000480889.1; ENSG00000177689.10.
DR GeneID; 139422; -.
DR KEGG; hsa:139422; -.
DR MANE-Select; ENST00000356790.2; ENSP00000368304.1; NM_182506.3; NP_872312.2.
DR UCSC; uc004dbw.3; human.
DR CTD; 139422; -.
DR GeneCards; MAGEB10; -.
DR HGNC; HGNC:25377; MAGEB10.
DR HPA; ENSG00000177689; Tissue enriched (testis).
DR MIM; 300761; gene.
DR neXtProt; NX_Q96LZ2; -.
DR PharmGKB; PA134952121; -.
DR VEuPathDB; HostDB:ENSG00000177689; -.
DR eggNOG; KOG4562; Eukaryota.
DR GeneTree; ENSGT00940000163797; -.
DR HOGENOM; CLU_039582_1_0_1; -.
DR InParanoid; Q96LZ2; -.
DR OMA; LYEGRKH; -.
DR OrthoDB; 1195799at2759; -.
DR PhylomeDB; Q96LZ2; -.
DR TreeFam; TF328505; -.
DR PathwayCommons; Q96LZ2; -.
DR SignaLink; Q96LZ2; -.
DR BioGRID-ORCS; 139422; 11 hits in 691 CRISPR screens.
DR GenomeRNAi; 139422; -.
DR Pharos; Q96LZ2; Tdark.
DR PRO; PR:Q96LZ2; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q96LZ2; protein.
DR Bgee; ENSG00000177689; Expressed in testis and 4 other tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.10.1200; -; 1.
DR Gene3D; 1.10.10.1210; -; 1.
DR InterPro; IPR037445; MAGE.
DR InterPro; IPR021072; MAGE_N.
DR InterPro; IPR041898; MAGE_WH1.
DR InterPro; IPR041899; MAGE_WH2.
DR InterPro; IPR002190; MHD_dom.
DR PANTHER; PTHR11736; PTHR11736; 1.
DR Pfam; PF01454; MAGE; 2.
DR Pfam; PF12440; MAGE_N; 1.
DR SMART; SM01373; MAGE; 1.
DR SMART; SM01392; MAGE_N; 1.
DR PROSITE; PS50838; MAGE; 1.
PE 1: Evidence at protein level;
KW Reference proteome; Tumor antigen.
FT CHAIN 1..347
FT /note="Melanoma-associated antigen B10"
FT /id="PRO_0000156718"
FT DOMAIN 111..310
FT /note="MAGE"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00127"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 56..92
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 328..347
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 56..82
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 50
FT /note="F -> S (in dbSNP:rs1368769)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_054500"
FT VARIANT 65
FT /note="R -> Q (in dbSNP:rs12557898)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_026773"
FT CONFLICT 6
FT /note="K -> E (in Ref. 1; BAB71522)"
FT /evidence="ECO:0000305"
FT CONFLICT 68
FT /note="Q -> R (in Ref. 1; BAB71522)"
FT /evidence="ECO:0000305"
FT CONFLICT 164
FT /note="F -> L (in Ref. 1; BAB71522)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 347 AA; 38971 MW; 26BA1493CF566A39 CRC64;
MPRGQKSKLR AREKRRQARG GLEDLIDALD ILEEEEESPP SASACLKDVF QSSLDGASNN
PHGLREAQST STSATAASHT RHPEGVNDQM EERPICTQDL EATDSFPRGP VDEKVIILVH
YLLYKYQMKE PITKADMLRN VTQMSKSQFP VILSRASEHL ELIFGLDLKE VEPNKHIYVL
VNKLDLGCDA KLSDETGVPK TGLLMTVLGI IFTNGNCVAE EEVWKVFNTM GLYDGIEHFM
FGEPRKLLTK DLVKENYLEY QQVPNSDPPR YQFLWGPRAH AETSKMKVLE FLAKVNDTAP
SEFSNWYTEA LQDEEERARA RVAAKARVSA TAGARSKVKS SKSSQLQ
