MAGBG_HUMAN
ID MAGBG_HUMAN Reviewed; 324 AA.
AC A2A368; A8MU30;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 24-MAR-2009, sequence version 2.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Melanoma-associated antigen B16;
DE AltName: Full=MAGE-B16 antigen;
GN Name=MAGEB16;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
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DR EMBL; AL161722; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS43927.1; -.
DR RefSeq; NP_001093391.1; NM_001099921.1.
DR RefSeq; XP_011543755.1; XM_011545453.2.
DR RefSeq; XP_011543756.1; XM_011545454.2.
DR AlphaFoldDB; A2A368; -.
DR SMR; A2A368; -.
DR BioGRID; 126578; 1.
DR IntAct; A2A368; 1.
DR STRING; 9606.ENSP00000382871; -.
DR iPTMnet; A2A368; -.
DR PhosphoSitePlus; A2A368; -.
DR BioMuta; MAGEB16; -.
DR jPOST; A2A368; -.
DR MassIVE; A2A368; -.
DR MaxQB; A2A368; -.
DR PaxDb; A2A368; -.
DR PeptideAtlas; A2A368; -.
DR PRIDE; A2A368; -.
DR ProteomicsDB; 253; -.
DR Antibodypedia; 64810; 61 antibodies from 12 providers.
DR DNASU; 139604; -.
DR Ensembl; ENST00000399985.1; ENSP00000382867.1; ENSG00000189023.10.
DR Ensembl; ENST00000399987.5; ENSP00000382869.1; ENSG00000189023.10.
DR Ensembl; ENST00000399988.5; ENSP00000382870.1; ENSG00000189023.10.
DR Ensembl; ENST00000399989.5; ENSP00000382871.1; ENSG00000189023.10.
DR GeneID; 139604; -.
DR KEGG; hsa:139604; -.
DR MANE-Select; ENST00000399988.6; ENSP00000382870.1; NM_001370158.1; NP_001357087.1.
DR UCSC; uc010ngt.1; human.
DR CTD; 139604; -.
DR DisGeNET; 139604; -.
DR GeneCards; MAGEB16; -.
DR HGNC; HGNC:21188; MAGEB16.
DR HPA; ENSG00000189023; Tissue enriched (testis).
DR MIM; 300762; gene.
DR neXtProt; NX_A2A368; -.
DR OpenTargets; ENSG00000189023; -.
DR PharmGKB; PA134922508; -.
DR VEuPathDB; HostDB:ENSG00000189023; -.
DR eggNOG; KOG4562; Eukaryota.
DR GeneTree; ENSGT00940000162825; -.
DR HOGENOM; CLU_039582_1_0_1; -.
DR InParanoid; A2A368; -.
DR OMA; EYVWGPR; -.
DR OrthoDB; 1195799at2759; -.
DR PhylomeDB; A2A368; -.
DR TreeFam; TF328505; -.
DR PathwayCommons; A2A368; -.
DR SignaLink; A2A368; -.
DR BioGRID-ORCS; 139604; 13 hits in 696 CRISPR screens.
DR GenomeRNAi; 139604; -.
DR Pharos; A2A368; Tdark.
DR PRO; PR:A2A368; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; A2A368; protein.
DR Bgee; ENSG00000189023; Expressed in testis and 3 other tissues.
DR ExpressionAtlas; A2A368; baseline and differential.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.10.1200; -; 1.
DR Gene3D; 1.10.10.1210; -; 1.
DR InterPro; IPR037445; MAGE.
DR InterPro; IPR021072; MAGE_N.
DR InterPro; IPR041898; MAGE_WH1.
DR InterPro; IPR041899; MAGE_WH2.
DR InterPro; IPR002190; MHD_dom.
DR PANTHER; PTHR11736; PTHR11736; 1.
DR Pfam; PF01454; MAGE; 1.
DR Pfam; PF12440; MAGE_N; 1.
DR SMART; SM01373; MAGE; 1.
DR SMART; SM01392; MAGE_N; 1.
DR PROSITE; PS50838; MAGE; 1.
PE 4: Predicted;
KW Reference proteome; Tumor antigen.
FT CHAIN 1..324
FT /note="Melanoma-associated antigen B16"
FT /id="PRO_0000311928"
FT DOMAIN 113..312
FT /note="MAGE"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00127"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 39..108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 64..85
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 38
FT /note="L -> F (in dbSNP:rs1410961)"
FT /id="VAR_037350"
FT VARIANT 128
FT /note="C -> Y (in dbSNP:rs1410962)"
FT /id="VAR_037351"
FT VARIANT 161
FT /note="H -> R (in dbSNP:rs5973488)"
FT /id="VAR_037352"
FT VARIANT 248
FT /note="M -> K (in dbSNP:rs4829391)"
FT /id="VAR_037354"
FT VARIANT 248
FT /note="M -> V (in dbSNP:rs4829390)"
FT /id="VAR_037353"
SQ SEQUENCE 324 AA; 36178 MW; 86F05F0E6FFD22BD CRC64;
MSQDQESPRC THDQHLQTFS ETQSLEVAQV SKALEKTLLS SSHPLVPGKL KEAPAAKAES
PLEVPQSFCS SSIAVTTTSS SESDEASSNQ EEEDSPSSSE DTSDPRNVPA DALDQKVAFL
VNFMLHKCQM KKPITKADML KIIIKDDESH FSEILLRASE HLEMIFGLDV VEVDPTTHCY
GLFIKLGLTY DGMLSGEKGV PKTGLLIIVL GVIFMKGNRA TEEEVWEVLN LTGVYSGKKH
FIFGEPRMLI TKDFVKEKYL EYQQVANSDP ARYEFLWGPR AKAETSKMKV LEFVAKVHGS
YPHSFPSQYA EALKEEEERA RARI
