MAGBG_MOUSE
ID MAGBG_MOUSE Reviewed; 363 AA.
AC Q9CWV4; Q3TJP9;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Melanoma-associated antigen B16;
DE AltName: Full=MAGE-B16 antigen;
GN Name=Mageb16;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Placenta;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
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DR EMBL; AK010362; BAB26882.1; -; mRNA.
DR EMBL; AK167347; BAE39446.1; -; mRNA.
DR EMBL; AL808111; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC115695; AAI15696.1; -; mRNA.
DR CCDS; CCDS53122.1; -.
DR RefSeq; NP_001107206.1; NM_001113734.1.
DR RefSeq; NP_082301.1; NM_028025.1.
DR RefSeq; XP_011245985.1; XM_011247683.2.
DR AlphaFoldDB; Q9CWV4; -.
DR SMR; Q9CWV4; -.
DR STRING; 10090.ENSMUSP00000109649; -.
DR PhosphoSitePlus; Q9CWV4; -.
DR PaxDb; Q9CWV4; -.
DR PeptideAtlas; Q9CWV4; -.
DR PRIDE; Q9CWV4; -.
DR Antibodypedia; 64810; 61 antibodies from 12 providers.
DR Ensembl; ENSMUST00000052283; ENSMUSP00000087292; ENSMUSG00000046942.
DR Ensembl; ENSMUST00000114016; ENSMUSP00000109649; ENSMUSG00000046942.
DR GeneID; 71967; -.
DR KEGG; mmu:71967; -.
DR UCSC; uc009trb.2; mouse.
DR CTD; 139604; -.
DR MGI; MGI:1919217; Mageb16.
DR VEuPathDB; HostDB:ENSMUSG00000046942; -.
DR eggNOG; KOG4562; Eukaryota.
DR GeneTree; ENSGT00940000162825; -.
DR HOGENOM; CLU_039582_1_0_1; -.
DR InParanoid; Q9CWV4; -.
DR OMA; EYVWGPR; -.
DR OrthoDB; 1195799at2759; -.
DR PhylomeDB; Q9CWV4; -.
DR TreeFam; TF328505; -.
DR BioGRID-ORCS; 71967; 3 hits in 72 CRISPR screens.
DR ChiTaRS; Mageb16; mouse.
DR PRO; PR:Q9CWV4; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q9CWV4; protein.
DR Bgee; ENSMUSG00000046942; Expressed in ectoplacental cone and 22 other tissues.
DR Genevisible; Q9CWV4; MM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.10.1200; -; 1.
DR Gene3D; 1.10.10.1210; -; 1.
DR InterPro; IPR037445; MAGE.
DR InterPro; IPR041898; MAGE_WH1.
DR InterPro; IPR041899; MAGE_WH2.
DR InterPro; IPR002190; MHD_dom.
DR PANTHER; PTHR11736; PTHR11736; 1.
DR Pfam; PF01454; MAGE; 1.
DR SMART; SM01373; MAGE; 1.
DR PROSITE; PS50838; MAGE; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; Tumor antigen.
FT CHAIN 1..363
FT /note="Melanoma-associated antigen B16"
FT /id="PRO_0000311929"
FT DOMAIN 128..327
FT /note="MAGE"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00127"
FT REGION 33..124
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 342..363
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 74
FT /note="Q -> K (in Ref. 1; BAE39446)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 363 AA; 40893 MW; 36D0769EC648289A CRC64;
MSQSSEECAA DQGQTCEETQ KLQVAAASID VEEPCSSPHL MATSLKDQTS EETQVSKDVE
EPCSSSQLLM ASDQDDSEDE TASTSSDLQH PYDSSSESTE DLDDQEVQGS PVIPPDQSDS
TDLPVMTVDG KVDFLVNYML YKYQVKEVMS MNDIMTLIVR EDEDRFHEIL MRASERMEMV
FGLDVKEVDP INHCYALFIK LGLTYDGMRN DEYSFPKTGL LILILGVVFM KGNRATEEEI
WEVLNPMGIY AGMTHFMFGD PRELITDEFV REQYLEYQPI ANSDPIQYEY VWGLRAKAET
SKMRVLEFVA KVHGSDPTVF LSQYEEALIE EEERTLTMLL EHADSSSTSG ESSSDTSSNF
SQV
