MAGBH_HUMAN
ID MAGBH_HUMAN Reviewed; 336 AA.
AC A8MXT2; A6NE98;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 14-MAY-2014, sequence version 3.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=Melanoma-associated antigen B17;
GN Name=MAGEB17;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: Formerly thought to be the product of a pseudogene, although
CC could be a bona fide protein. However, scarce EST evidence confirms
CC only the C-terminal sequence. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EAW98911.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC078993; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471074; EAW98911.1; ALT_SEQ; Genomic_DNA.
DR CCDS; CCDS59524.1; -.
DR RefSeq; NP_001264236.1; NM_001277307.1.
DR RefSeq; XP_011543869.1; XM_011545567.2.
DR AlphaFoldDB; A8MXT2; -.
DR SMR; A8MXT2; -.
DR BioGRID; 570806; 1.
DR STRING; 9606.ENSP00000382884; -.
DR iPTMnet; A8MXT2; -.
DR PhosphoSitePlus; A8MXT2; -.
DR BioMuta; MAGEB17; -.
DR EPD; A8MXT2; -.
DR MassIVE; A8MXT2; -.
DR PaxDb; A8MXT2; -.
DR PeptideAtlas; A8MXT2; -.
DR PRIDE; A8MXT2; -.
DR ProteomicsDB; 2350; -.
DR Antibodypedia; 5170; 8 antibodies from 7 providers.
DR DNASU; 645864; -.
DR Ensembl; ENST00000400003.1; ENSP00000382883.1; ENSG00000182798.10.
DR Ensembl; ENST00000400004.6; ENSP00000382884.2; ENSG00000182798.10.
DR GeneID; 645864; -.
DR KEGG; hsa:645864; -.
DR MANE-Select; ENST00000400004.6; ENSP00000382884.2; NM_001277307.2; NP_001264236.1.
DR UCSC; uc031tgu.2; human.
DR CTD; 645864; -.
DR GeneCards; MAGEB17; -.
DR HGNC; HGNC:17418; MAGEB17.
DR HPA; ENSG00000182798; Group enriched (pancreas, testis).
DR MIM; 300763; gene.
DR neXtProt; NX_A8MXT2; -.
DR OpenTargets; ENSG00000182798; -.
DR PharmGKB; PA134872991; -.
DR VEuPathDB; HostDB:ENSG00000182798; -.
DR eggNOG; KOG4562; Eukaryota.
DR GeneTree; ENSGT00940000166998; -.
DR HOGENOM; CLU_039582_1_0_1; -.
DR InParanoid; A8MXT2; -.
DR OMA; RGEDRCL; -.
DR OrthoDB; 1195799at2759; -.
DR PhylomeDB; A8MXT2; -.
DR TreeFam; TF328505; -.
DR PathwayCommons; A8MXT2; -.
DR BioGRID-ORCS; 645864; 15 hits in 682 CRISPR screens.
DR GenomeRNAi; 645864; -.
DR Pharos; A8MXT2; Tdark.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; A8MXT2; protein.
DR Bgee; ENSG00000182798; Expressed in body of pancreas and 32 other tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.10.1200; -; 1.
DR Gene3D; 1.10.10.1210; -; 1.
DR InterPro; IPR037445; MAGE.
DR InterPro; IPR021072; MAGE_N.
DR InterPro; IPR041898; MAGE_WH1.
DR InterPro; IPR041899; MAGE_WH2.
DR InterPro; IPR002190; MHD_dom.
DR PANTHER; PTHR11736; PTHR11736; 1.
DR Pfam; PF01454; MAGE; 1.
DR Pfam; PF12440; MAGE_N; 1.
DR SMART; SM01373; MAGE; 1.
DR SMART; SM01392; MAGE_N; 1.
DR PROSITE; PS50838; MAGE; 1.
PE 4: Predicted;
KW Reference proteome.
FT CHAIN 1..336
FT /note="Melanoma-associated antigen B17"
FT /id="PRO_0000332218"
FT DOMAIN 109..336
FT /note="MAGE"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00127"
FT REGION 1..108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 35..108
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 336 AA; 37578 MW; D6CA349109F6BEE4 CRC64;
MPRGQASKRR AREKRRQARG EDQCLGGAQA TAAEKEKLPS SSSPACQSPP QSFPNAGIPQ
ESQRASYPSS PASAVSLTSS DEGAKGQKGE SPNSFHGPSS SESTGRDLLN TKTGELVQFL
LNKYIRKEPI TREAMLKVIN RKYKQHFPEI LRRSTENVEV VFGLYLKEMD PSRQSYVLVG
KLDFPNQGSL SDGGGFPLSG LLMVLLSTIF MHGNRATEEE MWECLNALGM YKGRKHFIYG
EPQELVTKDL VREGYLEYQQ VPSSDPPRYE FLWGPRARAE TSKMKVLEFV AKLNDTVAST
YKSRYEEALR EEEEQARARA VARDSARARA SRSFQP
