ID   MAGBI_MACFA             Reviewed;         344 AA.
AC   Q4R998;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 44.
DE   RecName: Full=Melanoma-associated antigen B18;
DE   AltName: Full=MAGE-B18 antigen;
GN   Name=MAGEB18; ORFNames=QtsA-10460;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May enhance ubiquitin ligase activity of RING-type zinc
CC       finger-containing E3 ubiquitin-protein ligases. Proposed to act through
CC       recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at
CC       the E3:substrate complex (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with LNX1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8BQR7}.
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DR   EMBL; AB168198; BAE00323.1; -; mRNA.
DR   RefSeq; NP_001271700.1; NM_001284771.1.
DR   AlphaFoldDB; Q4R998; -.
DR   SMR; Q4R998; -.
DR   STRING; 9541.XP_005593262.1; -.
DR   Ensembl; ENSMFAT00000085756; ENSMFAP00000058236; ENSMFAG00000057172.
DR   GeneID; 101865647; -.
DR   CTD; 286514; -.
DR   eggNOG; KOG4562; Eukaryota.
DR   GeneTree; ENSGT00940000163449; -.
DR   OrthoDB; 1195799at2759; -.
DR   Proteomes; UP000233100; Chromosome X.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.10.10.1200; -; 1.
DR   Gene3D; 1.10.10.1210; -; 1.
DR   InterPro; IPR037445; MAGE.
DR   InterPro; IPR021072; MAGE_N.
DR   InterPro; IPR041898; MAGE_WH1.
DR   InterPro; IPR041899; MAGE_WH2.
DR   InterPro; IPR002190; MHD_dom.
DR   PANTHER; PTHR11736; PTHR11736; 1.
DR   Pfam; PF01454; MAGE; 1.
DR   Pfam; PF12440; MAGE_N; 1.
DR   SMART; SM01373; MAGE; 1.
DR   SMART; SM01392; MAGE_N; 1.
DR   PROSITE; PS50838; MAGE; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Reference proteome; Tumor antigen; Ubl conjugation pathway.
FT   CHAIN           1..344
FT                   /note="Melanoma-associated antigen B18"
FT                   /id="PRO_0000311931"
FT   DOMAIN          108..307
FT                   /note="MAGE"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00127"
FT   REGION          1..50
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          66..103
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          324..344
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        32..46
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        66..93
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        329..344
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   344 AA;  38607 MW;  FC145683AA9BB538 CRC64;
     MPRGQKSKLR AREKRHQARC ENQDLGATQA PVAEGESSSS ANLLFGDRPQ NLPAAETLSI
     PEALQGAPST TNTIAPVSCT SSNEGASNQD EKSLGSSREA EGWQEDPLSK KVVSLVHFLL
     QKYEKKEPIT KGDMIKFVIR KDKGHFNEIL KRASEHIELA FGVDLKEVDP IRHYYAFFSK
     LDLTYDETTS DEEKIPKTGL LMIALGVIFM NGNRAPEEAV WEIMNVMGVY ADRKHFLYGD
     PRKVMTKDLV QLKYLEYQQV PDSDPPRYEF LWGPRAHAET SKMKVLEFVA KMHDTVPSAF
     PSCYEEALRD EEQRAQARVA ARAHTAAMAN ARSRTTSSSF SHAK