MAGBI_MOUSE
ID MAGBI_MOUSE Reviewed; 327 AA.
AC Q8BQR7;
DT 08-JUN-2016, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Melanoma-associated antigen B18 {ECO:0000312|MGI:MGI:3045344};
DE AltName: Full=MAGE-B18 antigen {ECO:0000250|UniProtKB:Q96M61};
GN Name=Mageb18 {ECO:0000312|MGI:MGI:3045344};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000312|Proteomes:UP000000589};
RN [1] {ECO:0000312|EMBL:BAC32818.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Adipose tissue {ECO:0000312|EMBL:BAC32818.1};
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2] {ECO:0000312|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000312|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3] {ECO:0000312|EMBL:EDL29736.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000312|EMBL:AAI16802.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5] {ECO:0000305}
RP SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=22332604; DOI=10.1042/bj20112054;
RA Lin Y., Wen T., Meng X., Wu Z., Zhao L., Wang P., Hong Z., Yin Z.;
RT "The mouse Mageb18 gene encodes a ubiquitously expressed type I MAGE
RT protein and regulates cell proliferation and apoptosis in melanoma B16-F0
RT cells.";
RL Biochem. J. 443:779-788(2012).
CC -!- FUNCTION: May enhance ubiquitin ligase activity of RING-type zinc
CC finger-containing E3 ubiquitin-protein ligases. Proposed to act through
CC recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at
CC the E3:substrate complex. {ECO:0000250|UniProtKB:Q96M61}.
CC -!- SUBUNIT: Interacts with LNX1. {ECO:0000250|UniProtKB:Q96M61}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22332604}.
CC -!- TISSUE SPECIFICITY: Expressed in testis, stomach, large intestine,
CC small intestine, spleen, lymph node, bone marrow lymphocytes and blood
CC T-lymphocytes. Not detected in brain, heart, lung, liver or kidney (at
CC protein level). {ECO:0000269|PubMed:22332604}.
CC -!- DEVELOPMENTAL STAGE: In the testis, expression is detected from the
CC first day of birth, increases steadily in the first 3 weeks of life,
CC decreases around day 28, increases at day 35 and is stable between 35
CC and 56 days. Highly expressed in spermatogonia and is also observed in
CC primary and secondary spermatocytes but less so in spermatids (at
CC protein level). {ECO:0000269|PubMed:22332604}.
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DR EMBL; AK046641; BAC32818.1; -; mRNA.
DR EMBL; AL646048; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL732574; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL954178; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX322619; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX571789; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX640458; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466637; EDL29736.1; -; Genomic_DNA.
DR EMBL; BC116801; AAI16802.1; -; mRNA.
DR EMBL; BC137691; AAI37692.1; -; mRNA.
DR CCDS; CCDS30268.1; -.
DR RefSeq; NP_776144.1; NM_173783.3.
DR AlphaFoldDB; Q8BQR7; -.
DR SMR; Q8BQR7; -.
DR STRING; 10090.ENSMUSP00000109588; -.
DR PhosphoSitePlus; Q8BQR7; -.
DR PaxDb; Q8BQR7; -.
DR PRIDE; Q8BQR7; -.
DR ProteomicsDB; 252716; -.
DR Antibodypedia; 24619; 272 antibodies from 25 providers.
DR DNASU; 215641; -.
DR Ensembl; ENSMUST00000088137; ENSMUSP00000085460; ENSMUSG00000067649.
DR Ensembl; ENSMUST00000113955; ENSMUSP00000109588; ENSMUSG00000067649.
DR GeneID; 215641; -.
DR KEGG; mmu:215641; -.
DR UCSC; uc009tsn.1; mouse.
DR CTD; 286514; -.
DR MGI; MGI:3045344; Mageb18.
DR VEuPathDB; HostDB:ENSMUSG00000067649; -.
DR eggNOG; KOG4562; Eukaryota.
DR GeneTree; ENSGT00940000163449; -.
DR HOGENOM; CLU_039582_1_0_1; -.
DR InParanoid; Q8BQR7; -.
DR OMA; DPIRHCY; -.
DR OrthoDB; 1195799at2759; -.
DR PhylomeDB; Q8BQR7; -.
DR TreeFam; TF328505; -.
DR BioGRID-ORCS; 215641; 0 hits in 72 CRISPR screens.
DR ChiTaRS; Mageb18; mouse.
DR PRO; PR:Q8BQR7; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q8BQR7; protein.
DR Bgee; ENSMUSG00000067649; Expressed in white adipose tissue and 3 other tissues.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.10.1200; -; 1.
DR Gene3D; 1.10.10.1210; -; 1.
DR InterPro; IPR037445; MAGE.
DR InterPro; IPR021072; MAGE_N.
DR InterPro; IPR041898; MAGE_WH1.
DR InterPro; IPR041899; MAGE_WH2.
DR InterPro; IPR002190; MHD_dom.
DR PANTHER; PTHR11736; PTHR11736; 1.
DR Pfam; PF01454; MAGE; 1.
DR SMART; SM01373; MAGE; 1.
DR SMART; SM01392; MAGE_N; 1.
DR PROSITE; PS50838; MAGE; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Reference proteome; Tumor antigen; Ubl conjugation pathway.
FT CHAIN 1..327
FT /note="Melanoma-associated antigen B18"
FT /id="PRO_0000436362"
FT DOMAIN 91..289
FT /note="MAGE"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00127"
FT REGION 1..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..71
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 327 AA; 37203 MW; B92A6A7999168A63 CRC64;
MPRGQKSKLR AREKRRQARA KNAQEKEASP GPFYGCPHQA SPVASMPTSP NMPMGEQSTF
SHSYTSTSDQ NLDEKSSDDS EDTEDWCKDP INHKVVLLVQ FLMEKYQKKE VITKADMLKY
VIKTSKNHFN EILKRASEHM ELAFGIDLKE VDPNRHCYAL FNKLEHTFDG VMGEEKMPSS
GLLMIVLGVI FMNDNCVSET EIWNVLSMMG VYANRKHFIY GDPKKVITED MVQLKYLEYQ
QVPNSNPPSF EFTWGPRACA EISKMKILEF WAKIHDTTPD SFPTLYEAAL KDEEERAQAR
AVARAHTAAM ASPYSRATVC SSSHTNI
