ID   MAGD2_PONAB             Reviewed;         606 AA.
AC   Q5RFC2;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Melanoma-associated antigen D2;
DE   AltName: Full=MAGE-D2 antigen;
GN   Name=MAGED2;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulates the expression, localization to the plasma membrane
CC       and function of the sodium chloride cotransporters SLC12A1 and SLC12A3,
CC       two key components of salt reabsorption in the distal renal tubule.
CC       {ECO:0000250|UniProtKB:Q9UNF1}.
CC   -!- SUBUNIT: Interacts with GNAS. {ECO:0000250|UniProtKB:Q9UNF1}.
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DR   EMBL; CR857238; CAH89535.1; -; mRNA.
DR   RefSeq; NP_001124666.1; NM_001131194.2.
DR   RefSeq; XP_009233159.1; XM_009234884.1.
DR   RefSeq; XP_009233160.1; XM_009234885.1.
DR   AlphaFoldDB; Q5RFC2; -.
DR   SMR; Q5RFC2; -.
DR   STRING; 9601.ENSPPYP00000022819; -.
DR   PRIDE; Q5RFC2; -.
DR   Ensembl; ENSPPYT00000023781; ENSPPYP00000022819; ENSPPYG00000020385.
DR   GeneID; 100171511; -.
DR   KEGG; pon:100171511; -.
DR   CTD; 10916; -.
DR   eggNOG; KOG4562; Eukaryota.
DR   GeneTree; ENSGT00940000161795; -.
DR   HOGENOM; CLU_032317_2_0_1; -.
DR   InParanoid; Q5RFC2; -.
DR   OMA; IDKSDHL; -.
DR   OrthoDB; 1195799at2759; -.
DR   TreeFam; TF352132; -.
DR   Proteomes; UP000001595; Chromosome X.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0007565; P:female pregnancy; IEA:Ensembl.
DR   GO; GO:0070294; P:renal sodium ion absorption; ISS:UniProtKB.
DR   Gene3D; 1.10.10.1200; -; 1.
DR   Gene3D; 1.10.10.1210; -; 1.
DR   InterPro; IPR037445; MAGE.
DR   InterPro; IPR041898; MAGE_WH1.
DR   InterPro; IPR041899; MAGE_WH2.
DR   InterPro; IPR028810; MAGED2.
DR   InterPro; IPR002190; MHD_dom.
DR   PANTHER; PTHR11736; PTHR11736; 1.
DR   PANTHER; PTHR11736:SF11; PTHR11736:SF11; 1.
DR   Pfam; PF01454; MAGE; 1.
DR   SMART; SM01373; MAGE; 1.
DR   PROSITE; PS50838; MAGE; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Phosphoprotein; Reference proteome; Tumor antigen.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UNF1"
FT   CHAIN           2..606
FT                   /note="Melanoma-associated antigen D2"
FT                   /id="PRO_0000240630"
FT   DOMAIN          279..478
FT                   /note="MAGE"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00127"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          52..204
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          248..275
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          534..563
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        63..121
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        132..146
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        542..563
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         2
FT                   /note="N-acetylserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UNF1"
FT   MOD_RES         5
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UNF1"
FT   MOD_RES         72
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UNF1"
FT   MOD_RES         157
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UNF1"
FT   MOD_RES         190
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UNF1"
FT   MOD_RES         191
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UNF1"
FT   MOD_RES         194
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UNF1"
FT   MOD_RES         197
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UNF1"
FT   MOD_RES         244
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UNF1"
FT   MOD_RES         247
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UNF1"
FT   MOD_RES         264
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UNF1"
FT   MOD_RES         265
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UNF1"
SQ   SEQUENCE   606 AA;  64948 MW;  DF1A82C834E92DAB CRC64;
     MSDTSESGAG LTRFQAEASE KDSSSMMQTL LTVTQNVEVP ETLKASKALE VSEDVKVSKA
     SGVSKATEVS KTPEAQEAPA TQASSTTQLT DTQVLATENK SVAADTKKQN ADPQAVTMPA
     TETKKVSHVA DTKVNTKAQE TEAAPSQASA DEPEPESAAA QSQENQDTRP KVKAKKARKV
     KHLDGEEDGS SDQSQASGTT GGRRVSKALM ASMARRASRG PIAFWARRAS RTRLAAWARR
     ALLSLRSPKA RRGKARRRAA KLQSSQEPEA PPPRDVALLQ GRANDLVKYL LAKDQTKIPI
     KRSDMLKDII KEYTDVYPEI IERAGYSLEK VFGIQLKEID KNDHLYILLS TLEPTDAGIL
     GTTKDSPKLG LLMVLLSIIF MNGNRSSEAV IWEVLRKLGL RPGIHHSLFG DVKKLITDEF
     VKQKYLDYAR VPNSNPPEYE FFWGLRSYYE TSKMKVLKFA CKVQKKDPKE WAAQYREAME
     ADLKAAAEAA AEAKARAEIR ARMGIGLGSE NAAGPCNWDE ADIGPWAKAR IQAGAEAKAK
     AQESGSASTG ASTSTNNSAS ASASTSGGFS AGASLTATLT FGLFAGLGGA GASTSGSSGA
     CGFSYK